Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory

Kim, Mi Eun; Park, Hee Ra; Gong, Eun Ji; Choi, Seon Young; Kim, Hyung Sik; Lee, Joo Young

doi:10.1016/j.fct.2011.09.017

Cited by 73 publications

(51 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The amounts of diet-derived phytoestrogens typically consumed may be below the concentration range that inhibits tyrosine kinases (Lee et al, 2005). Similar to genistein, biphasic effects of curcumin on the nervous system have also been reported , including a biphasic doseresponse effect on hippocampal neurogenesis in mice (Kim et al, 2011a).…”

Section: B Environmental Toxicantsmentioning

confidence: 95%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

Self Cite

View full text Add to dashboard Cite

Section: B Environmental Toxicantsmentioning

confidence: 95%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

Self Cite

View full text Add to dashboard Cite

“…6 In this regard, BPA exposure has been linked to the development of obesity, insulin resistance, metabolic syndrome, diabetes, and atherosclerosis. [6][7][8][9] An epidemiologic association was observed between high urinary BPA levels and cardiovascular disease. Each increase in urinary BPA of 4.5 mg/L was associated with a 13% increase in the incidence of coronary heart disease within 10 years, although the significance was lost after adjustment for traditional cardiovascular risk factors.…”

mentioning

confidence: 99%

The Choice of Hemodialysis Membrane Affects Bisphenol A Levels in Blood

Bosch-Panadero¹,

Mas

Sanchez-Ospina

et al. 2015

JASN

View full text Add to dashboard Cite

Bisphenol A (BPA), a component of some dialysis membranes, accumulates in CKD. Observational studies have linked BPA exposure to kidney and cardiovascular injury in humans, and animal studies have described a causative link. Normal kidneys rapidly excrete BPA, but insufficient excretion may sensitize patients with CKD to adverse the effects of BPA. Using a crossover design, we studied the effect of dialysis with BPA-containing polysulfone or BPA-free polynephron dialyzers on BPA levels in 69 prevalent patients on hemodialysis: 28 patients started on polysulfone dialyzers and were switched to polynephron dialyzers; 41 patients started on polynephron dialyzers and were switched to polysulfone dialyzers. Results were grouped for analysis. Mean BPA levels increased after one hemodialysis session with polysulfone dialyzers but not with polynephron dialyzers. Chronic (3-month) use of polysulfone dialyzers did not significantly increase predialysis serum BPA levels, although a trend toward increase was detected (from 48.866.8 to 69.1610.1 ng/ml). Chronic use of polynephron dialyzers reduced predialysis serum BPA (from 70.668.4 to 47.167.5 ng/ml, P,0.05). Intracellular BPA in PBMCs increased after chronic hemodialysis with polysulfone dialyzers (from 0.03960.002 to 0.04360.001 ng/10 6 cells, P,0.01), but decreased with polynephron dialyzers (from 0.04560.001 to 0.03660.001 ng/10 6 cells, P,0.01). Furthermore, chronic hemodialysis with polysulfone dialyzers increased oxidative stress in PBMCs and inflammatory marker concentrations in circulation. In vitro, polysulfone membranes released significantly more BPA into the culture medium and induced more cytokine production in cultured PBMCs than did polynephron membranes. In conclusion, dialyzer BPA content may contribute to BPA burden in patients on hemodialysis.

show abstract

“…Because foetuses are extremely sensitive to chemicals with hormonelike activity, and even small changes induced by oestrogen-mimicking chemicals can lead to changes in brain function and behaviour (4), there is a growing concern that BPA exposure can disrupt foetal brain development/function or neuronal differentiation. Recent studies have demonstrated that BPA exposure can affect neurogenesis during gestation (5,6) or in young adult mice (7).…”

mentioning

confidence: 99%

A Unique Pattern of Bisphenol A Effects on Nerve Growth Factor Gene Expression in Embryonic Mouse Hypothalamic Cell Line N-44

Warita

Mitsuhashi

Hoshi

et al. 2014

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

We investigated the toxicity of bisphenol A (BPA) by determining the gene expression of nerve growth factor (Ngf) in the embryonic mouse cell line mHypoE-N44 derived from the hypothalamus exposed to BPA dose range between 0.02 and 200 µmol L -1 for 3 h. Ngf mRNA levels decreased in a dose-dependent manner, with significant reductions observed in the 2 to 50 µmol L -1 BPA treatment groups compared to controls. However, at 100 to 200 µmol L -1 the Ngf mRNA gradually increased and was significantly higher than control, while the expression of the apoptosis-related genes Caspase 3 and transformation-related protein 73 decreased significantly. These results suggest that in an embryonic hypothalamic cell line the higher doses of BPA induce a unique pattern of Ngf gene expression and that BPA has the potential to suppress apoptosis essential for early-stage brain development.

show abstract

Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory

Cited by 73 publications

References 46 publications

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

The Choice of Hemodialysis Membrane Affects Bisphenol A Levels in Blood

A Unique Pattern of Bisphenol A Effects on Nerve Growth Factor Gene Expression in Embryonic Mouse Hypothalamic Cell Line N-44

Contact Info

Product

Resources

About