Exposure to Bisphenol A and Bisphenol S and Incident Type 2 Diabetes: A Case–Cohort Study in the French Cohort D.E.S.I.R.

Rancière, Fanny; Botton, Jérémie; Slama, Rémy; Lacroix, Marlène Z.; Debrauwer, Laurent; Munier, Charles; Roussel, Ronan; Balkau, Beverley; Magliano, Dianna J.

doi:10.1289/ehp5159

Cited by 102 publications

(53 citation statements)

References 33 publications

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“…Another study aimed to determine the risk of developing T2D over a 9-year period in the French cohort called "Data from an Epidemiological Study on the Insulin Resistance Syndrome" (D.E.S.I.R). Of 755 participants, 201 cases of diabetes were diagnosed, and results suggested that participants in higher quartiles of BPA exposure had nearly double the risk of developing T2D (Rancière et al, 2019). Overall, available data provide strong evidence supporting a link between bisphenol exposure and MetS.…”

Section: Exposure To Plasticizers and Risk For Metabolic Syndrome: Epmentioning

confidence: 89%

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction

et al. 2021

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Since the 1950s, the production of plastics has increased 200-fold, reaching 360 million tonnes in 2019. Plasticizers, additives that modify the flexibility and rigidity of the product, are ingested as they migrate into food and beverages. Human exposure is continuous and widespread; between 75 and 97% of urine samples contain detectable levels of bisphenols and phthalates, the most common plasticizers. Concern over the toxicity of plasticizers arose in the late 1990s, largely focused around adverse developmental and reproductive effects. More recently, many studies have demonstrated that exposure to plasticizers increases the risk for obesity, type 2 diabetes, and cardiovascular disease (CVD). In the 2000s, many governments including Canada, the United States and European countries restricted the use of certain plasticizers in products targeted towards infants and children. Resultant consumer pressure motivated manufacturers to substitute plasticizers with analogues, which have been marketed as safe. However, data on the effects of these new substitutes are limited and data available to-date suggest that many exhibit similar properties to the chemicals they replaced. The adverse effects of plasticizers have largely been attributed to their endocrine disrupting properties, which modulate hormone signaling. Adipose tissue has been well-documented to be a target of the disrupting effects of both bisphenols and phthalates. Since adipose tissue function is a key determinant of cardiovascular health, adverse effects of plasticizers on adipocyte signaling and function may underlie their link to cardiovascular disease. Herein, we discuss the current evidence linking bisphenols and phthalates to obesity and CVD and consider how documented impacts of these plasticizers on adipocyte function may contribute to the development of CVD.

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Section: Exposure To Plasticizers and Risk For Metabolic Syndrome: Epmentioning

confidence: 89%

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction

et al. 2021

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“…Now a longitudinal study published in Environmental Health Perspectives , examining not just BPA but also its widely used substitute bisphenol S (BPS), adds to the evidence. 7 The study found positive associations between incidence of diabetes and exposure to both BPA and BPS, independent of traditional risk factors.…”

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confidence: 80%

Bisphenol Exposure and Type 2 Diabetes: New Evidence for a Potential Risk Factor

Seltenrich¹

2020

Environ Health Perspect

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The plasticizer bisphenol A (BPA), used in can linings, thermal paper, and polycarbonate plastics, 1,2 has been associated with a wide range of health outcomes, including type 2 diabetes. 3 Numerous experimental 4 and population-based 5,6 studies over the last decade have explored the BPA-diabetes relationship. Now a longitudinal study published in Environmental Health Perspectives, examining not just BPA but also its widely used substitute bisphenol S (BPS), adds to the evidence. 7 The study found positive associations between incidence of diabetes and exposure to both BPA and BPS, independent of traditional risk factors.The research included 755 individuals followed over 9 years as part of the French cohort Data from an Epidemiological Study on the Insulin Resistance Syndrome (D.E.S.I.R.). 8 The participants, who were diabetes-free when recruited, provided urine samples at enrollment (between 1994 and 1996) and again 3 years later. The authors estimated participants' exposure to BPA and BPS based on urine metabolites of these bisphenols.A total of 201 D.E.S.I.R. participants received diabetes diagnoses during the 9-year follow-up period, but the risk was not equally distributed. The authors estimated that participants in the

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“…BPA has been considered a risk factor in the etiology of type 2 diabetes (T2D) (Alonso-Magdalena et al, 2006;Ropero et al, 2008;Nadal et al, 2009;Batista et al, 2012). Epidemiological and prospective studies associated BPA exposure with alterations in glucose homeostasis or T2D incidence, independently of obesity or other traditional factors (Lang et al, 2008;Shankar and Teppala, 2011;Beydoun et al, 2014;Ranciere et al, 2019). Recent epidemiological data associated BPS urine levels with T2D development in a case-cohort study (Ranciere et al, 2019) and a case-control study (Duan et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological and prospective studies associated BPA exposure with alterations in glucose homeostasis or T2D incidence, independently of obesity or other traditional factors (Lang et al, 2008;Shankar and Teppala, 2011;Beydoun et al, 2014;Ranciere et al, 2019). Recent epidemiological data associated BPS urine levels with T2D development in a case-cohort study (Ranciere et al, 2019) and a case-control study (Duan et al, 2018). BPF has been recently associated with abdominal 58 obesity in children (Jacobson et al, 2019), but association with T2D is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

Marroquí

Martı́nez-Pinna

Castellano-Muñoz

et al. 2020

Preprint

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Bisphenol-S (BPS) and Bisphenol-F (BPF) are current Bisphenol-A (BPA) substitutes. Here we used pancreatic β-cells from wild type (WT) and estrogen receptor β (ERβ) knockout (BERKO) mice to investigate the effects of BPS and BPF on insulin secretion, and the expression and activity of ion channels involved in β-cell function. BPS or BPF rapidly increased insulin release and diminished ATP-sensitive K+ (KATP) channel activity. Similarly, 48 h treatment with BPS or BPF enhanced insulin release and decreased the expression of several ion channel subunits in β-cells from WT mice, yet no effects were observed in cells from BERKO mice. PaPE-1, a ligand designed to preferentially trigger extranuclear-initiated ER pathways, mimicked the effects of bisphenols, suggesting the involvement of extranuclear-initiated ERβ pathways. Molecular dynamics simulations indicated differences in ERβ ligand-binding domain dimer stabilization and solvation free energy among different bisphenols and PaPE-1. Our data suggest a mode of action involving ERβ whose activation alters three key cellular events in β-cell, namely ion channel expression and activity, and insulin release. These results may help to improve the hazard identification of bisphenols.

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Exposure to Bisphenol A and Bisphenol S and Incident Type 2 Diabetes: A Case–Cohort Study in the French Cohort D.E.S.I.R.

Cited by 102 publications

References 33 publications

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction

Bisphenol Exposure and Type 2 Diabetes: New Evidence for a Potential Risk Factor

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

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