Exposure to atmospheric Ag, TiO2, Ti and SiO2 engineered nanoparticles modulates gut inflammatory response and microbiota in mice

Guilloteau, Eva; Djouina, Madjid; Caboche, Ségolène; Waxin, Christophe; Deboudt, Karine; Beury, Delphine; Hot, David; Pichavant, Muriel; Dubuquoy, Laurent; Launay, David; Vignal, Cécile; Choël, M.; Body-Malapel, Mathilde

doi:10.1016/j.ecoenv.2022.113442

Cited by 10 publications

(2 citation statements)

References 49 publications

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“…Guilloteau reported the impact of different types of nanoparticles on the gut microbiota. Some researchers determined that the presence of some MNAs such as Ag, TiO 2 , Ti, and SiO 2 is related with the reduction of bacteria Proteobacteria Phylum class Deltaproteobacteria and order Desulfovibrionales in the intestinal microbiota, which is linked with PD .…”

Section: Resultsmentioning

confidence: 99%

Possible Signaling Pathways in the Gut Microbiota–Brain Axis for the Development of Parkinson’s Disease Caused by Chronic Consumption of Food Additives

Martinez-Vega,

Galván-Menéndez-Conde,

Freyre-Fonseca

2023

ACS Chem. Neurosci.

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It is well-known that consumption of synthetic and natural food additives has both positive and negative effects in the human body. However, it is not clear yet how food additives are related to the development of Parkinson’s disease. Therefore, in this review work, the food additive effects related to the gut microbiota–brain axis and the processes that are carried out to develop Parkinson’s disease are studied. To this end, a systematic literature analysis is performed with the selected keywords and the food additive effects are studied to draw possible routes of action. This analysis leads to the proposition of a model that explains the pathways that relate the ingestion of food additives to the development of Parkinson’s disease. This work motivates further research that ponders the safety of food additives by measuring their impacts over the gut microbiota–brain axis.

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Section: Resultsmentioning

confidence: 99%

Possible Signaling Pathways in the Gut Microbiota–Brain Axis for the Development of Parkinson’s Disease Caused by Chronic Consumption of Food Additives

Martinez-Vega,

Galván-Menéndez-Conde,

Freyre-Fonseca

2023

ACS Chem. Neurosci.

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“…The release of pro-inflammatory cytokines, such as IL-1β, IL-8, and TNF-α, and antiinflammatory cytokines, such as IL-10 and TGF-β1, caused by M1 and M2 macrophage activation, respectively, was evaluated following oral administration for 28 d, although in vivo monocyte uptake (Figure 7) or M1 an M2 polarization (Figure 8) were not detected. Three different doses (50, 300, and 2000 mg/kg) were administered as cytokines have the potential to be released at even low dosage levels [55,56]. As mentioned in the previous section, the Kupffer cell polarization to M1 and M2 macrophages leads to the secretion of pro-inflammatory and anti-inflammatory cytokines, respectively [52,54].…”

Section: In Vivo Cytokine Release By Siomentioning

confidence: 99%

Oral Excretion Kinetics of Food-Additive Silicon Dioxides and Their Effect on In Vivo Macrophage Activation

Kwon,

Youn,

Choi

2024

IJMS

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A food additive, silicon dioxide (SiO2) is commonly used in the food industry as an anti-caking agent. The presence of nanoparticles (NPs) in commercial food-grade SiO2 has raised concerns regarding their potential toxicity related to nano size. While recent studies have demonstrated the oral absorption and tissue distribution of food-additive SiO2 particles, limited information is available about their excretion behaviors and potential impact on macrophage activation. In this study, the excretion kinetics of two differently manufactured (fumed and precipitated) SiO2 particles were evaluated following repeated oral administration to rats for 28 d. The excretion fate of their intact particles, decomposed forms, or ionic forms was investigated in feces and urine, respectively. Monocyte uptake, Kupffer cell activation, and cytokine release were assessed after the oral administration of SiO2 particles. Additionally, their intracellular fates were determined in Raw 264.7 cells. The results revealed that the majority of SiO2 particles were not absorbed but directly excreted via feces in intact particle forms. Only a small portion of SiO2 was eliminated via urine, predominantly in the form of bioconverted silicic acid and slightly decomposed ionic forms. SiO2 particles were mainly present in particle forms inside cells, followed by ionic and silicic acid forms, indicating their slow conversion into silicic acid after cellular uptake. No effects of the manufacturing method were observed on excretion and fates. Moreover, no in vivo monocyte uptake, Kupffer cell polarization, or cytokine release were induced by orally administered SiO2 particles. These finding contribute to understanding the oral toxicokinetics of food-additive SiO2 and provide valuable insights into its potential toxicity.

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Biotoxicity and exposure pathways of engineered silver nanoparticles released in the environment

Li,

Cummins

2024

Nanotoxicology for Agricultural and Environmental Applications

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Exposure to atmospheric Ag, TiO2, Ti and SiO2 engineered nanoparticles modulates gut inflammatory response and microbiota in mice

Cited by 10 publications

References 49 publications

Possible Signaling Pathways in the Gut Microbiota–Brain Axis for the Development of Parkinson’s Disease Caused by Chronic Consumption of Food Additives

Possible Signaling Pathways in the Gut Microbiota–Brain Axis for the Development of Parkinson’s Disease Caused by Chronic Consumption of Food Additives

Oral Excretion Kinetics of Food-Additive Silicon Dioxides and Their Effect on In Vivo Macrophage Activation

Biotoxicity and exposure pathways of engineered silver nanoparticles released in the environment

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