Exposure to anesthetic gases in the operating rooms and assessment of non-carcinogenic risk among health care workers

Kiani, Fatemeh; Jorfi, Sahand; Soltani, Farhad; Ghanbari, Saeed; Rezaee, Ramin; Mohammadi, Mohammad Javad

doi:10.1016/j.toxrep.2023.06.007

Cited by 6 publications

(3 citation statements)

References 34 publications

(51 reference statements)

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“…Common gases include nitrous oxide and various halogenated agents. While patients benefit from their use, healthcare workers exposed during their professional routine are at risk of health effects [ 165 , 166 , 167 , 168 , 169 ]. Long-term exposure may lead to symptoms such as headaches, dizziness, and nausea and has been associated with reproductive issues, including miscarriages and fertility problems in healthcare workers.…”

Section: Resultsmentioning

confidence: 99%

“…Long-term exposure may lead to symptoms such as headaches, dizziness, and nausea and has been associated with reproductive issues, including miscarriages and fertility problems in healthcare workers. Additionally, there is a potential for liver and kidney damage, as well as an increased risk of cancer [ 168 , 169 , 170 , 171 , 172 ]. Available data reviewed in [ 166 , 167 ] suggested an association with genotoxic risks, particularly for nitrous oxide and halogenated agents, but not for propofol and its metabolites.…”

Section: Resultsmentioning

confidence: 99%

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The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

Ladeira,

Møller,

Giovannelli

et al. 2024

Toxics

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Biomonitoring of human populations exposed to chemical substances that can act as potential mutagens or carcinogens, may enable the detection of damage and early disease prevention. In recent years, the comet assay has become an important tool for assessing DNA damage, both in environmental and occupational exposure contexts. To evidence the role of the comet assay in human biomonitoring, we have analysed original research studies of environmental or occupational exposure that used the comet assay in their assessments, following the PRISMA-ScR method (preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews). Groups of chemicals were designated according to a broad classification, and the results obtained from over 300 original studies (n = 123 on air pollutants, n = 14 on anaesthetics, n = 18 on antineoplastic drugs, n = 57 on heavy metals, n = 59 on pesticides, and n = 49 on solvents) showed overall higher values of DNA strand breaks in the exposed subjects in comparison with the unexposed. In summary, our systematic scoping review strengthens the relevance of the use of the comet assay in assessing DNA damage in human biomonitoring studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

Ladeira,

Møller,

Giovannelli

et al. 2024

Toxics

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“…When sampling with sorbent tubes, the gases are passively collected on an adsorbent and then analysed in a laboratory using techniques such as gas chromatography. Gas chromatography allows the separation and quantification of individual gas components, which enables the identification of potential sources of contamination and the assessment of occupational exposure [23,24].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Surgical Safety: Microbiological Air Control in Operating Theatres at University Medical Centre Maribor

Gradisnik,

Bunc,

Ravnik

et al. 2024

Diagnostics

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Background: the aim of the study was to assess microbiological air quality in operating theatres by determining the level of microbiological contamination of the air and critical surfaces using the passive air sampling method and compliance of the operating theatre staff with infection control measures. Materials and methods: The prospective study was conducted in the surgical block of the University Medical Centre Maribor. For two months continuously, ten operating theatres were assessed for microbial contamination of air and surfaces during quiet and active times of the day. A passive air sampling method with Petri dishes on an agar specially adapted for this purpose (plate count agar) was used. In addition, ten surgical procedures were observed to assess staff compliance with recommended practises. Results: Air samples met microbiological standards in all operating theatres. In both sampling sessions of the day (quiet and active periods), microbial contamination of the air was always within the limit of 10 CFU/m3. The average number of bacterial colonies was zero to two during quiet phases and one to four during active phases. Approximately 60% of the isolates from the operating theatres belonged mainly to the genus Staphylococcus: S. epidermidis (36% of the isolates), S. hominis (17.5%) and S. haemolyticus (5.5%). The rest were identified as Streptococcus anginosus (23%) and Bacillus sp. (18%). Pathogenic bacteria and moulds were not present. In regard to staff compliance with good surgical practise, the former varied by behaviour and function, with non-compliance in pre-operative skin preparation and operating theatre congestion being notable. The cleanliness of the environment was satisfactory. Conclusions: Microbiological air control is extremely important for the safety and success of both surgical and postoperative practises. In spite of good results obtained in the study, further improvements in surgical staff compliance with good surgical practise are essential to reduce surgical site infections.

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Providing a Safe Pregnancy Experience for Surgeons

Glazer,

Gunderson,

Deroo

et al. 2024

JAMA Surg

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ImportanceChildbearing has been a particular barrier to successful recruitment and retention of women in surgery. Pregnant surgeons are more likely to have major pregnancy complications, such as preterm delivery, intrauterine growth restriction, infertility, and miscarriage, compared with nonsurgeons. The average obstetric complication rate for surgeons ranges between 25% and 82% in the literature and is considerably higher than that in the general US population at 5% to 15%.ObservationsThe risks that pregnant surgeons experience were individually analyzed. These risks included missed prenatal care; musculoskeletal hazards, such as prolonged standing, lifting, and bending; long work hours; overnight calls; exposure to teratogenic agents, such as ionizing radiation, anesthetic gases, chemotherapy agents, and methyl methacrylate; and psychological stress and discrimination from the long-standing stigma associated with balancing motherhood and professional life.Conclusions and RelevanceA clear, translatable, and enforceable policy addressing perinatal care of surgeons was proposed, citing evidence of the risks reviewed from the literature. A framework of protection for pregnant individuals is essential for attracting talented students into surgery, retaining talented surgical trainees and faculty, and protecting pregnant surgeons and their fetuses.

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Exposure to anesthetic gases in the operating rooms and assessment of non-carcinogenic risk among health care workers

Cited by 6 publications

References 34 publications

The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

Enhancing Surgical Safety: Microbiological Air Control in Operating Theatres at University Medical Centre Maribor

Providing a Safe Pregnancy Experience for Surgeons

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