Exposure to ambient fine particulate matter is associated with changes in fasting glucose and lipid profiles: a nationwide cohort study

Abstract

Background: Ambient fine particulate matter is a rising concern for global public health. It was recently suggested that exposure to fine particulate matter may contribute to the development of diabetes and dyslipidaemia. This study aims to examine the potential associations of ambient particulate matter exposure with changes in fasting glucose and lipid profiles in Koreans. Method: We used the data from the National Health Insurance Service-National Sample Cohort (NHIS-NSC), a nationwide database representative of the Korean population. A total of 85,869 individuals aged ≥20 years were included. Multiple regression analyses were conducted to assess the associations between exposure to particulate matter and changes in fasting glucose and lipid profiles at 2-year intervals after adjusting for confounders. Results: Significant associations were observed between an increase in interquartile range for particulate matter < 2.5 μm in diameter (PM 2.5) and elevated levels of fasting glucose and low-density lipoprotein cholesterol (p for trend = 0.015 and 0.010, respectively), while no association for particulate matter sized 2.5-10 μm in diameter (PM 10-2.5) was noted after adjusting for the other covariates. Subgroup analyses showed stronger associations in individuals who were older (≥60 years) or physically inactive. Conclusions: Fine particulate matter exposure affects worsening fasting glucose and low-density lipoprotein cholesterol levels, with no evidence of an association for coarse particulate matter.

The Protective Effect of Topical Spermidine on Dry Eye Disease with Retinal Damage Induced by Diesel Particulate Matter2.5

“…Increasing epidemiological studies have recently shown that exposure to ambient PM 2.5 may have a hazardous influence on the metabolic system, including an increased risk of dyslipidemia [ 63 , 64 ]. One nationwide cohort study demonstrated that exposure to ambient PM 2.5 is associated with worsening LDL-C levels [ 66 ]. Another cohort study suggested that high levels of fine PM exposure were closely correlated with increasing TC and LDL-C levels [ 67 ].…”

The Protective Effect of Oral Application of Corni Fructus on the Disorders of the Cornea, Conjunctiva, Lacrimal Gland and Retina by Topical Particulate Matter 2.5

“…However, our findings showed that CFW contributes to the normalization of TC and LDL-C levels. Increasing epidemiological studies have recently shown that PM 2.5 may have a hazardous influence on the metabolic system, including an increased risk of dyslipidemia [ 36 , 37 ]. One cohort study demonstrated that exposure to PM 2.5 is associated with worsening LDL-C levels [ 36 ].…”

“…Increasing epidemiological studies have recently shown that PM 2.5 may have a hazardous influence on the metabolic system, including an increased risk of dyslipidemia [ 36 , 37 ]. One cohort study demonstrated that exposure to PM 2.5 is associated with worsening LDL-C levels [ 36 ]. In this cohort study, researchers obtained atmospheric monitoring data for the daily mean concentration of hourly measured PM 2.5 from the Ministry of Environment of Korea, and multiple regression analyses were conducted to assess the associations between exposure to PM 2.5 and changes in lipid profiles at two-year intervals.…”

Saponins of Korean Red Ginseng May Protect Human Skin from Adipokine-Associated Inflammation and Pigmentation Resulting from Particulate Matter Exposure

“…The harmful health impact of PM exposure is not confined to those organs exposed to PM. In fact, PM exposure has been associated with several systemic conditions, including dyslipidemia, obesity, insulin resistance, and diabetes mellitus [ 4 , 5 , 6 ]. Among various mechanisms that link exposure to PM to these metabolic disorders, changes in adipokine levels, including adiponectin and leptin, have been highlighted in previous studies [ 7 , 8 ].…”