Exposure to ambient air pollution-does it affect semen quality and the level of reproductive hormones?

Radwan, Michał; Jurewicz, Joanna; Polańska, Kinga; Sobala, Wojciech; Radwan, Paweł; Bochenek, M.; Hanke, Wojciech

doi:10.3109/03014460.2015.1013986

Cited by 117 publications

(95 citation statements)

References 30 publications

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“…Previous studies suggested that exposure to NO 2 (or NO x ) and CO were associated with increased abnormalities in sperm morphology, 12,19 but not associated with sperm concentration, count, motility, nor aneuploidy 6,12,19,20,32 , which was in line with our results. In contrast, an in vivo study concluded that NO 2 inhalation might reduce the sperm production in rats; 14 Boggia et al found significantly lower sperm total motility, not sperm count, in occupational NO 2 exposed workers; 33 however, the NO 2 exposures in these two studies tended to be much higher than that in the epidemiological studies for general population, which may partly explain the inconsistence.…”

Section: Discussionsupporting

confidence: 93%

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Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Liu

Zhou²,

Ma³

et al. 2017

Environ. Sci. Technol.

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Evidence concerning the association between ambient gaseous air pollutant exposures and semen quality is sparse, and findings in previous studies remain largely inconsistent. We enrolled 1759 men with 2184 semen examinations at a large reproductive medical center in Wuhan, China between 2013 and 2015. Inverse distance weighting interpolation was performed to estimate individual exposures to SO2, NO2, CO and O3 during the entire period (lag 0–90 days) and key periods (lag 0-9, 10-14, 70-90 days) of sperm development. Linear mixed models were used to analyze exposure-response relationships. SO2 exposure with 0-90 days lag was significantly associated with monotonically decreased sperm concentration (β for each interquartile range increase of exposure: −0.14; 95% CI: −0.23, −0.05), sperm count (−0.21; −0.30, −0.12) and total motile sperm count (−0.16; −0.25, −0.08). Significant associations were observed for total and progressive motility only when SO2 exposure was at the highest quintile (all Ptrend < 0.05). Similar trends were observed for SO2 exposure with 70-90 days lag. NO2, CO, or O3 exposure was not significantly associated with semen quality. Our results suggest that ambient SO2 exposure adversely affects semen quality, and highlight the potential to improve semen quality by reducing ambient SO2 exposure during early stage of sperm development.

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Section: Discussionsupporting

confidence: 93%

“…6,11 While a study in China and another study in Poland suggested that SO 2 and NO x might adversely affect sperm morphology, rather than sperm concentration or motility, Farhat et al did not observe any significant association for SO 2 and NO 2 exposures in Brazil. 12,19,20 …”

Section: Introductionmentioning

confidence: 99%

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Liu

Zhou²,

Ma³

et al. 2017

Environ. Sci. Technol.

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“…Along with an alteration of sperm parameters (other than ejaculate volume and sperm count), they observed a significantly higher level of FSH in the exposed group (mean ± SE: 4.1 ± 0.3 UI/l vs 3.2 ± 0.2; p < 0.05), although this remained within the normal value range [54]. Radwan et al [66] also found a negative association between testosterone levels and exposure to certain air pollutants (PM10, PM2.5, CO and NOx).…”

Section: Impact Of Air Pollution On the Male Gametementioning

confidence: 90%

“…For example, De Rosa et al found an alteration in sperm parameters associated with significantly higher levels of FSH in the group exposed to exhaust, although they remained within the normal value range [54], while Radwan et al reported a negative association between testosterone levels and exposure to certain air pollutants (PM10, PM2.5, CO and NO 2 ) [66].…”

Section: Action As Endocrine Disruptorsmentioning

confidence: 99%

“…These alterations involves a reduction in sperm mobility [54,[56][57][58][59][60][61][62], or in the quality of their movement [54,56]. Altered sperm morphology with a reduction in the percentage of normal shapes, notably the morphology of the head, is also frequently mentioned [21,56,57,[59][60][61][62][63][64][65][66]. There are discordant results for sperm counts, with some studies reporting a significant decrease in the sperm concentration in semen after exposure to certain forms of air pollution [56,57,60,65,67], whereas others not observing any significant effects [59,64,68].…”

Section: Impact Of Air Pollution On the Male Gametementioning

confidence: 99%

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Does air pollution play a role in infertility?: a systematic review

et al. 2017

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Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

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Decrease of air pollution during lockdown in Tuscany (Italy): An effect on sperm DNA fragmentation?

Calamai

Ammar

Marchiani

et al. 2023

Environ and Mol Mutagen

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Exposure to ambient air pollution-does it affect semen quality and the level of reproductive hormones?

Abstract: The present study provides suggestive evidence of an association between ambient air pollution and sperm quality. Further research is needed to explore this association in more detail. Individual precise exposure assessment would be needed for more detailed risk characterization.

Cited by 117 publications

References 30 publications

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Does air pollution play a role in infertility?: a systematic review

Decrease of air pollution during lockdown in Tuscany (Italy): An effect on sperm DNA fragmentation?

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