Exposure to ambient air pollution and osteoarthritis; an animal study

Fitriyah, Abyadul; Nikolenko, Denis; Abdelbasset, Walid Kamal; Maashi, Marwah Suliman; Jalil, Abduladheem Turki; Abdulkadhm, Mohammed Mustafa; Samieva, G.U.; Abed, Azher M.; Amaral, Larissa Souza; Mustafa, Yasser Fakri

doi:10.1016/j.chemosphere.2022.134698

Cited by 21 publications

(7 citation statements)

References 46 publications

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“…In addition, AmpC -lactamasesproducing ESBL-producing bacteria can result in a false negative when trying to detect ESBL. More crucially, the presence of the gene as detected by PCR does not necessarily mean that the gene is expressed because the expression of -lactamase genes depends on the environmental factors including the use of antibiotics [27][28][29][30][31].…”

Section: The Bla Temmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Section: The Bla Temmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Regards to the consequence of HIF activation in human tumors, multiple HIF inhibitors have been investigated to inhibit HIF (reviewed by ref [109]), however, raised doselimiting side effects limited their clinical utility, which may be improved in combination with immunotherapy or use them just as co-adjuvant to the enhancement of existing immunotherapies (Table 2). Hypoxia affects mitochondria respiration resulting in elevated ROS production, which in turn induces the exhaustion of CD8 + T cells expressing coinhibitory molecules such as PD-1 and Tim-3 [110].…”

Section: Hypoxiamentioning

confidence: 99%

Reprogramming the tumor microenvironment to improve the efficacy of cancer immunotherapies

Faraj¹,

Al-Athari²,

Mohie³

et al. 2022

Med Oncol

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The immunotherapeutic approaches based on checkpoint inhibitors, tumor vaccination, immune cell-based therapy, and cytokines were developed to engage the patient's immune system against cancer and better survival of them. While potent, however, preclinical and clinical data have identified that abnormalities in the tumor microenvironment (TME) can affect the efficacy of immunotherapies in some cancers. It is therefore imperative to develop new therapeutic interventions that will enable to overcome tumor-supportive TME and restrain anti-tumor immunity in patients that acquire resistance to current immunotherapies. Therefore, recognition of the essential nature of the tolerogenic TME may lead to a shift from the immunesuppressive TME to an immune-stimulating phenotype. Here, we review the composition of the TME and its effect on tumor immunoediting and then present how targeted monotherapy or combination therapies can be employed for reprogramming educated TME to improve current immunotherapies outcomes or elucidate potential therapeutic targets.

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“…Gaseous pollutants in ambient air are associated with adverse effects on human health and climate. 1,2 It is therefore highly important to design and build effective materials that can be used for removing them from the atmospheric environment, in catalysts for converting them to less harmful species, or in gas sensors for determining their concentration. In all cases, such materials can benet from atomic clusters that can enhance the adsorption of the target gas and/or promote specic catalytic reactions.…”

Section: Introductionmentioning

confidence: 99%