Exposure to ambient air pollution and cognitive decline: Results of the prospective Three-City cohort study

Duchesne, Jeanne; Gutierrez, Laure‐Anne; Carrière, Isabelle; Mura, Thibault; Chen, Jie; Vienneau, Danielle; Hoogh, Kees de; Helmer, Catherine; Jacquemin, Bénédicte; Berr, Claudine; Mortamais, Marion

doi:10.1016/j.envint.2022.107118

Cited by 22 publications

(12 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The exposure levels of ambient PM 2.5 and PM 10 observed in our study population were lower than those reported in China [ 20 ], India [ 27 ], and Pakistan [ 28 ], higher than the levels reported in the United States (US) and Canada [ 29 , 30 ], and within similar ranges as reported in France [ 31 ]. Zhou et al reported the ranges of ambient PM in China using 589 pairs of data encompassing 57 urban and rural cities and regions [ 20 ].…”

Section: Discussionsupporting

confidence: 61%

Effect of Short- to Long-Term Exposure to Ambient Particulate Matter on Cognitive Function in a Cohort of Middle-Aged and Older Adults: KoGES

Lee

Kim

Song

et al. 2022

IJERPH

View full text Add to dashboard Cite

Exposure to ambient air pollution and its threat to human health is a global concern, especially in the elderly population. Therefore, more in-depth studies are required to understand the extent of the harmful effects of particulate matter (PM) based on duration and levels of exposure. An investigation was conducted to determine the association between short- (1–14 days), medium- (1, 3, and 6 months), and long-term (1, 2, and 3 years) exposure to air pollutants (PM2.5 and PM10) and cognitive function among Koreans (4175 participants, mean age 67.8 years, 55.2% women) aged over 50 years. Higher levels of PM2.5 exposure for short to long term and PM10 exposure for medium to long term were found to be associated with decreased cognitive function, as indicated by lower scores of the Mini-Mental State Examination adopted in Korean (K-MMSE). There were significant effect modifications by sex, age group, alcohol consumption, physical activity, and smoking status in the association between long-term PM2.5 and PM10 exposure and cognitive function. These findings, which underscore the importance of the efforts to reduce the exposure levels and durations of air pollutants, especially in the vulnerable elderly population, provide evidence for establishing more stringent policies for air pollution regulations.

show abstract

Section: Discussionsupporting

confidence: 61%

Effect of Short- to Long-Term Exposure to Ambient Particulate Matter on Cognitive Function in a Cohort of Middle-Aged and Older Adults: KoGES

Lee

Kim

Song

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“… 17 Another study also showed detrimental effects of SO 2 on the total and memory subdomain score of the MMSE in normal elderly population. 28 However, most of previous studies evaluating the effect of air pollution on the risk of dementia or cognitive decline have been performed in normal elderly individuals without dementia from community‐based cohorts and most of these studies did not include SO 2 as a predictor, 1 , 4 , 5 , 6 , 7 , 11 , 12 , 29 , 30 , 31 , 32 , 33 it may be possible that the effects of SO 2 in AD were unrevealed in previous studies. Further studies are warranted to evaluate whether SO 2 is associated with rapid clinical progression after AD occurrence rather than the occurrence of AD.…”

Section: Discussionmentioning

confidence: 99%

Air pollution is associated with faster cognitive decline in Alzheimer's disease

Lee

Yoon

et al. 2023

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Objective Although chronic exposure to air pollution is associated with an increased risk of dementia in normal elderlies, the effect of chronic exposure to air pollution on the rates of cognitive decline in Alzheimer's disease (AD) has not been elucidated. Methods In this longitudinal study, a total of 269 patients with mild cognitive impairment or early dementia due to AD with the evidence of brain β‐amyloid deposition were followed‐up for a mean period of 4 years. Five‐year normalized hourly cumulative exposure value of each air pollutant, such as carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and particulate matter (PM2.5 and PM10), was computed based on nationwide air pollution database. The effects of chronic exposure to air pollution on longitudinal cognitive decline rate were evaluated using linear mixed models. Results Higher chronic exposure to SO2 was associated with a faster decline in memory score, whereas chronic exposure to CO, NO2, and PM10 were not associated with the rate of cognitive decline. Higher chronic exposure to PM2.5 was associated with a faster decline in visuospatial score in apolipoprotein E ε4 carriers. These effects remained significant even after adjusting for potential confounders. Interpretation Our findings suggest that chronic exposure to SO2 and PM2.5 is associated with faster clinical progression in AD.

show abstract

“…As previously described, 29 , 30 ambient concentrations of

, and BC were estimated using hybrid land use regression (LUR) models developed for Western Europe within the framework of the Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) study. 31

and

concentration data for the year 2010 were extracted from the European Environment Agency AirBase database that compiles data recorded at routine monitoring stations (including traffic, industrial, and background sites).…”

Section: Methodsmentioning

confidence: 99%

Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study

Duchesne,

Carrière,

Artero

et al. 2023

Environ Health Perspect

Self Cite

View full text Add to dashboard Cite

Background: Growing epidemiological evidence suggests an adverse relationship between exposure to air pollutants and cognitive health, and this could be related to the effect of air pollution on vascular health. Objective: We aim to evaluate the association between air pollution exposure and a magnetic resonance imaging (MRI) marker of cerebral vascular burden, white matter hyperintensities (WMH). Methods: This cross-sectional analysis used data from the French Three-City Montpellier study. Randomly selected participants 65–80 years of age underwent an MRI examination to estimate their total and regional cerebral WMH volumes. Exposure to fine particulate matter ( ), nitrogen dioxide ( ), and black carbon (BC) at the participants’ residential address during the 5 years before the MRI examination was estimated with land use regression models. Multinomial and binomial logistic regression assessed the associations between exposure to each of the three pollutants and categories of total and lobar WMH volumes. Results: Participants’ ( ) median age at MRI was 70.7 years [interquartile range (IQR): 6.1], and 52% ( ) were women. Median exposure to air pollution over the 5 years before MRI acquisition was 24.3 (IQR: 1.7) for , 48.9 (14.6) for , and 2.66 (0.60) for BC. We found no significant association between exposure to the three air pollutants and total WMH volume. We found that exposure was significantly associated with higher risk of temporal lobe WMH burden [odds ratio (OR) for an (95% confidence interval: 1.41, 2.36) for the second volume tercile, 2.04 (1.59, 2.61) for the third volume tercile, reference: first volume tercile]. Associations for other regional WMH volumes were inconsistent. Conclusion: In this population-based study in older adults, exposure was associated with increased risk of high WMH volume in the temporal lobe, strengthening the evidence on adverse effect on the brain. Further studies looking at different markers of cerebrovascular damage are still needed to document the potential vascular effects of air pollution. https://doi.org/10.1289/EHP12231

show abstract

Exposure to ambient air pollution and cognitive decline: Results of the prospective Three-City cohort study

Cited by 22 publications

References 43 publications

Effect of Short- to Long-Term Exposure to Ambient Particulate Matter on Cognitive Function in a Cohort of Middle-Aged and Older Adults: KoGES

Effect of Short- to Long-Term Exposure to Ambient Particulate Matter on Cognitive Function in a Cohort of Middle-Aged and Older Adults: KoGES

Air pollution is associated with faster cognitive decline in Alzheimer's disease

Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study

Contact Info

Product

Resources

About