Exposure to air pollutant mixture and gestational diabetes mellitus in Southern California: Results from electronic health record data of a large pregnancy cohort

Sun, Yi; Li, Xia; Benmarhnia, Tarik; Chen, Jiu‐Chiuan; Avila, Chantal; Sacks, David A.; Chiu, Vicki; Slezak, Jeff; Molitor, John; Getahun, Darios; Wu, Jun

doi:10.1016/j.envint.2021.106888

Cited by 65 publications

(73 citation statements)

References 75 publications

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“…This kind of model can get effect estimate with one-quantile increases in the air pollutants mixture. It does not require all exposure variables in the mixture have the same effect direction with the outcome, and thus can capture the nonlinear, nonadditive effects of both individual and mixture of environmental pollutants ( 42 ). Meanwhile, this method has been widely used to explore the effects of air pollutants mixture on human health ( 42 , 43 ).…”

Section: Methodsmentioning

confidence: 99%

“…It does not require all exposure variables in the mixture have the same effect direction with the outcome, and thus can capture the nonlinear, nonadditive effects of both individual and mixture of environmental pollutants ( 42 ). Meanwhile, this method has been widely used to explore the effects of air pollutants mixture on human health ( 42 , 43 ). Furthermore, to evaluate the protective effect of residential greenness, we added the NDVI to the mixture model.…”

Section: Methodsmentioning

confidence: 99%

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Residential greenness attenuated association of long-term air pollution exposure with elevated blood pressure: Findings from polluted areas in Northern China

Mei

Zhao

Zhou

et al. 2022

Front. Public Health

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BackgroundEvidence on the hypertensive effects of long-term air pollutants exposure are mixed, and the joint hypertensive effects of air pollutants are also unclear. Sparse evidence exists regarding the modifying role of residential greenness in such effects.MethodsA cross-sectional study was conducted in typically air-polluted areas in northern China. Particulate matter with diameter < 1 μm (PM1), particulate matter with diameter < 2.5 μm (PM2.5), particulate matter with diameter < 10 μm (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3) were predicted by space–time extremely randomized trees model. We used the Normalized Difference Vegetation Index (NDVI) to reflect residential green space. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were examined. We also calculated the pulse pressure (PP) and mean arterial pressure (MAP). Generalized additive model and quantile g-computation were, respectively, conducted to investigate individual and joint effects of air pollutants on blood pressure. Furthermore, beneficial effect of NDVI and its modification effect were explored.ResultsLong-term air pollutants exposure was associated with elevated DBP and MAP. Specifically, we found a 10-μg/m3 increase in PM2.5, PM10, and SO2 were associated with 2.36% (95% CI: 0.97, 3.76), 1.51% (95% CI: 0.70, 2.34), and 3.54% (95% CI: 1.55, 5.56) increase in DBP; a 10-μg/m3 increase in PM2.5, PM10, and SO2 were associated with 1.84% (95% CI: 0.74, 2.96), 1.17% (95% CI: 0.52, 1.83), and 2.43% (95% CI: 0.71, 4.18) increase in MAP. Air pollutants mixture (one quantile increase) was positively associated with increased values of DBP (8.22%, 95% CI: 5.49, 11.02) and MAP (4.15%, 95% CI: 2.05, 6.30), respectively. These identified harmful effect of air pollutants mainly occurred among these lived with low NDVI values. And participants aged ≥50 years were more susceptible to the harmful effect of PM2.5 and PM10 compared to younger adults.ConclusionsOur study indicated the harmful effect of long-term exposure to air pollutants and these effects may be modified by living within higher green space place. These evidence suggest increasing residential greenness and air pollution control may have simultaneous effect on decreasing the risk of hypertension.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Residential greenness attenuated association of long-term air pollution exposure with elevated blood pressure: Findings from polluted areas in Northern China

Mei

Zhao

Zhou

et al. 2022

Front. Public Health

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“…Therefore, the human adverse health outcome should be investigated, taking into account multiple substances. In the literature, only a few recent studies investigated the effects of air pollutant mixtures and health effects [ 201 , 202 , 203 , 204 , 205 ]. Recently developed methodologies able to evaluate the presence of multiple chemicals can also be applied in the air pollution field [ 206 ] and statistical approaches to estimate multi-pollutant mixtures or multiple correlated exposure effects on human health are an important area of ongoing research, also for regulatory purposes (reviewed in [ 207 ]).…”

Section: Discussionmentioning

confidence: 99%

Air Pollution: Possible Interaction between the Immune and Nervous System?

Serafini

Maddalon

Iulini

et al. 2022

IJERPH

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Exposure to environmental pollutants is a serious and common public health concern associated with growing morbidity and mortality worldwide, as well as economic burden. In recent years, the toxic effects associated with air pollution have been intensively studied, with a particular focus on the lung and cardiovascular system, mainly associated with particulate matter exposure. However, epidemiological and mechanistic studies suggest that air pollution can also influence skin integrity and may have a significant adverse impact on the immune and nervous system. Air pollution exposure already starts in utero before birth, potentially causing delayed chronic diseases arising later in life. There are, indeed, time windows during the life of individuals who are more susceptible to air pollution exposure, which may result in more severe outcomes. In this review paper, we provide an overview of findings that have established the effects of air pollutants on the immune and nervous system, and speculate on the possible interaction between them, based on mechanistic data.

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“…Our results showed that urinary MeP and EtP were associated with increased risk of benign nodules, and all three parabens were each associated with an increased risk of thyroid cancer in our single pollutant models. However, humans are simultaneously exposed to a complex mixture of pollutants from various sources [53]. Therefore, we applied a multi-pollutant model with three parabens and found that EtP contributed most to the positive risk of thyroid cancer and benign nodules.…”

Section: Discussionmentioning

confidence: 99%

Environmental Paraben Exposure and Risk of Thyroid Cancer and Benign Nodules: A Pilot Study

Wu¹,

Zhu²,

Liu³

et al. 2021

Preprint

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Parabens are widely used as preservatives, which have been found to affect thyroid function in toxicological studies. However, population studies on whether they are associated with thyroid tumor remain unclear. This study aims to investigate the relationship between environmental paraben exposure and thyroid cancer and benign nodules. The detectable percentages of methyl paraben, ethyl paraben, and propyl paraben in the urinary samples of 425 study subjects were 99.06%, 95.29% and 92.00%, respectively. In the single pollutant model, we found statistically significant difference between certain parabens and thyroid cancer/ benign nodules. Further, we found the mixture effect of parabens on increased risk of thyroid cancer (OR = 0.24, 95% CI: 0.18, 0.31) and benign nodule (OR =1.33, 95% CI: 0.86, 1.80). The significant gender-associated effects were found in associations with certain parabens and thyroid cancer and benign nodules (Both P for interactions < 0.05). Overall, our results showed that individual exposure of paraben mixtures may be associated with the risk of thyroid cancer and benign nodules, and there were gender differences.

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Exposure to air pollutant mixture and gestational diabetes mellitus in Southern California: Results from electronic health record data of a large pregnancy cohort

Cited by 65 publications

References 75 publications

Residential greenness attenuated association of long-term air pollution exposure with elevated blood pressure: Findings from polluted areas in Northern China

Residential greenness attenuated association of long-term air pollution exposure with elevated blood pressure: Findings from polluted areas in Northern China

Air Pollution: Possible Interaction between the Immune and Nervous System?

Environmental Paraben Exposure and Risk of Thyroid Cancer and Benign Nodules: A Pilot Study

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