Exposure–Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case–Control Studies

Olsson, Ann; Vermeulen, Roel; Schüz, Joachim; Kromhout, Hans; Pesch, Beate; Peters, Susan; Behrens, Thomas; Portengen, Lützen; Mirabelli, Dario; Gustavsson, Per; Kendzia, Benjamin; Almansa, Josué; Luzon, Véronique; Vlaanderen, Jelle; Stücker, Isabelle; Guida, Florence; Consonni, Dario; Caporaso, Neil E.; Landi, Maria Teresa; Field, John K.; Brüske, Irene; Wichmann, Heinz Erich; Siemiatycki, Jack; Parent, Marie; Richiardi, Lorenzo; Merletti, Franco; Jöckel, Karl Heinz; Ahrens, Wolfgang; Pohlabeln, Hermann; Plato, Nils; Tardón, Adonina; Заридзе, Давид; McLaughlin, John; Demers, Paul A.; Szeszenia-Da̧browska, Neonila; Lissowska, Jolanta; Rudnai, Péter; Fabiánovà, Eleonóra; Dumitru, Rodica Stanescu; Bencko, Vladimír; Foretová, Lenka; Janout, Vladimí­r; Boffetta, Paolo; Bueno‐de‐Mesquita, Bas; Forastiére, Francesco; Brüning, Thomas; Straif, Kurt

doi:10.1097/ede.0000000000000604

Cited by 71 publications

(62 citation statements)

References 32 publications

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“…Asbestos exposure carries well‐known risks for both nonmalignant and malignant outcomes, most commonly pleural disease, asbestosis, lung cancer, and pleural and peritoneal mesothelioma . The effects of latency and dose‐response characteristics remain important questions, particularly at lower exposure levels …”

Section: Introductionmentioning

confidence: 99%

Change in prevalence of asbestos‐related disease among sheet metal workers 1986 to 2016

West

Sokas

Welch

2019

American J Industrial Med

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Background: A medical screening program began in 1986 for sheet metal workers exposed to asbestos, primarily while working alongside insulators applying spray-on asbestos materials, a practice banned in 1973. Exposure continues during maintenance, renovation, and repair. Methods: Radiographic abnormalities among 26 397 sheet metal workers examined from 1986 to 2016 were analyzed by year of entry into the trade. Logistic regression was used to examine risk factors for parenchymal and pleural abnormalities among the overall study population and among the subcohort who entered the trade after 1973. Results: Prevalence of parenchymal disease was 17.4% for those starting work before 1950 compared with 0.8% for those starting work after 1973 (adjusted prevalence odds ratio [pOR] = 26.65, 95% confidence interval [CI] = 18.46-38.46). For each calendar year after 1973, entering the trade 1 year later was associated with an estimated 12.7% decreased odds of acquiring asbestos-related disease (adjusted pOR = 0.873, 95% CI = 0.832-0.916).Conclusion: Sheet metal workers who began work after the US implemented environmental and occupational regulations develop asbestos-related disease at much reduced rates, consistent with regulatory projections made for nonmalignant asbestos-related disease by the Occupational Safety and Health Administration at the time. Cancer remains a concern among this cohort, and lung cancer screening recommendations should consider year of entry into the trade. This study highlights the importance of regulatory intervention and of continued surveillance. K E Y W O R D S asbestos, asbestosis, construction, nonmalignant asbestos-related disease, sheet metal worker

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Section: Introductionmentioning

confidence: 99%

Change in prevalence of asbestos‐related disease among sheet metal workers 1986 to 2016

West

Sokas

Welch

2019

American J Industrial Med

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“…Corrugated sheets used in industrial construction (15 samples) were admixed with ~10% chrysotile and ~3% crocidolite asbestos. Many publications and databases regarding exposure to asbestos omit the issue of the concentration of total dust [1,[6][7]. Based on the data of Table 1 we found that employees carrying out works at residential blocks were exposed to higher concentrations of respirable asbestos fibres than those at industrial buildings.…”

Section: Resultsmentioning

confidence: 82%

“…During intensive removal works working time exceeded 40-hours per week, up to 80 hours per week. The risk of asbestosis increases with increasing cumulative doses (in years), based on the concentrations of respirable asbestos fibers obtained in personal measuring [7]. Breathing the respirable asbestos fibers (of length > 5 µm, diameter < 3 µm, and aspect ratio > 3:1) can cause non-cancer diseases of respiratory system (asbestosis, pleural disease) and some certain cancers (pleural and peritoneal mesothelioma, lung cancer -especially if occupational exposure to asbestos is accompanied by tobacco smoking).…”

Section: Resultsmentioning

confidence: 99%

Air Pollution during Asbestos Removal

Sąkol

Graca

2018

Pol. J. Environ. Stud.

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“…Villeneuve et al, in a population-based case-control study in Canada, reported the OR 1.28 (95% CI: 1.02-1.61) for generally exposed subjects and when the exposure categorized into low and medium or high exposure the ORs was 1.17 (95% CI: 0.92-0.50) and 2.16 (95% CI: 1.21-3.88) respectively [21]. In a meta-analysis, Moon et al concluded that the great variety of asbestos exposures between nations may arise from differences in culture, technology, legislation and attitude toward the risk [22]. The prevalence of smokers in different countries also strongly influenced the risk of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia

Suraya¹,

Nowak

Sulistomo

et al. 2020

IJERPH

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Indonesia has limited data on asbestos-related diseases despite abundant use. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR = 2.04, 95% CI = 1.21–3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI = 1.01–9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI = 1.71–44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards.

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Exposure–Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case–Control Studies

Abstract: Supplemental Digital Content is available in the text.

Cited by 71 publications

References 32 publications

Change in prevalence of asbestos‐related disease among sheet metal workers 1986 to 2016

Change in prevalence of asbestos‐related disease among sheet metal workers 1986 to 2016

Air Pollution during Asbestos Removal

Asbestos-Related Lung Cancer: A Hospital-Based Case-Control Study in Indonesia

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