Exposure profiles and predictors of a cocktail of environmental chemicals in Chinese men of reproductive age

Pan, Yang; Wang, Jie; Hong, Aobo; Huang, Lili; Xie, Qitong; Wang, Yixin; Xiong, Chengliang; Meng, Tian-Qing; Pan, An; Chen, Da

doi:10.1016/j.chemosphere.2022.134337

Cited by 9 publications

(3 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Any unbound inhibitor was washed away and as a result labelled, and only cells in which the caspase has been activated were detected using a fluorescence reader ◂ necessary (e.g. mathematical approach and modern statistical models as in Yang et al [46] or D'Almeida et al [47] research). The exposure assessment (the first step of risk assessment) and identification of hazards at the workplace at the presence of mixtures requires a careful study of the workplace and physical and toxicological principles to ensure a comprehensive evaluation [48].…”

Section: Discussionmentioning

confidence: 99%

“…It must be emphasized that in this work we used simple method based on synergy indexes and isobolographic analysis after IC 50 determination and the prediction of combined toxicity used in this research can be different with practical data, hence the advanced calculation of toxicity prediction could be necessary (e.g. mathematical approach and modern statistical models as in Yang et al [ 46 ] or D'Almeida et al [ 47 ] research). The exposure assessment (the first step of risk assessment) and identification of hazards at the workplace at the presence of mixtures requires a careful study of the workplace and physical and toxicological principles to ensure a comprehensive evaluation [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin

Miranowicz-Dzierżawska

Zapór

Skowroń

et al. 2022

Toxicol Res.

View full text Add to dashboard Cite

Data on the cumulative effects of chemical substances are necessary for the proper risk assessment, but their availability is still insufficient. The aim of the study was to evaluate the cytotoxic effect of methyl paraben (MePB) and dibutyl phthalate (DBP) on the cells of the skin line (A431) and to compare the cytotoxic effects of the tested substances after single application to A431 cells with the effects of an equimolar/equitoxic (1:1) binary mixture of these compounds as well as their mixtures in ratio 1:3: and 3:1. On the basis of the obtained results, it was found that there were interactions between the tested compounds in terms of cytotoxic effect on A431, assessed on the basis of metabolic activity of cells (MTT test) and integrity of their cell membranes (NRU test). The obtained values of synergy coefficients (SI) and isobolographic analysis indicate that between the tested chemicals in a two-component equimolar mixture (1:1) there is a synergism of action, which, at a high DBP content in the mixture (> 50%) turned into antagonism. Observations using a holotomographic microscope show morphological changes in A431 cells after exposure to both DBP and MePB separately and binary mixtures of these compounds, compared to untreated cells. The observed changes in cell morphology seem to be more pronounced when the cells are exposed to the binary mixtures of DBP and MePB than when exposed to these substances individually, which may confirm the synergy of cytotoxic activity between them (this phenomenon was observed for the higher of the tested concentrations in all tested proportions). It is important to consider such effects when considering the effects of cumulative exposure in the risk assessment in order not to underestimate the risk of adverse effects associated with exposure to chemical mixtures.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin

Miranowicz-Dzierżawska

Zapór

Skowroń

et al. 2022

Toxicol Res.

View full text Add to dashboard Cite

show abstract

“…Phthalate metabolites were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS, Applied Biosystem/AB SCIEX 5500 Triple Quadrupole) with a negative electrospray ionization mode. The detail of pretreatment, separation, and measurement procedures was described previously [ 33 ]. We focused on 8 phthalate metabolites that had ≥ 85% of concentrations above the limits of detection (LODs), including monoethyl phthalate (MEP), monoisobutyl phthalate (MiBP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), four metabolites of DEHP [mono-2-ethylhexyl phthalate (MEHP), mono (mono-2-ethyl-5-oxohexyl phthalate (MEOHP), 2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP)].…”

Section: Methodsmentioning

confidence: 99%

Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age

Xiao,

Hu,

Tang

et al. 2024

BMC Public Health

Self Cite

View full text Add to dashboard Cite

Background Previous studies of singletons evaluating prenatal phthalate exposure and early neurodevelopment reported mixed results and the associations could be biased by parental, obstetrical, and genetic factors. Methods A co-twin control design was employed to test whether prenatal phthalate exposure was associated with children’s neurocognitive development. We collected information from 97 mother-twin pairs enrolled in the Wuhan Twin Birth Cohort between March 2016 and October 2018. Fourteen phthalate metabolites were measured in maternal urine collected at each trimester. Neurodevelopmental differences in twins at the age of two were examined as the outcome of interest. Multiple informant model was used to examine the covariate-adjusted associations of prenatal phthalate exposure with mental development index (MDI) and psychomotor development index (PDI) scores assessed at 2 years of age based on Bayley Scales of Infant Development (Second Edition). This model also helps to identify the exposure window of susceptibility. Results Maternal urinary levels of mono-2-ethyl-5-oxohexyl phthalate (MEOHP) (β = 1.91, 95% CI: 0.43, 3.39), mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (β = 1.56, 95% CI: 0.33, 2.79), and the sum of di-(2-ethylhexyl) phthalate metabolites (∑DEHP) (β = 1.85, 95% CI: 0.39, 3.31) during the first trimester showed the strongest and significant positive associations with intra-twin MDI difference. When stratified with twin chorionicity, the positive associations of monoethyl phthalate (MEP), monoisobutyl phthalate (MiBP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), individual DEHP metabolites, and ∑DEHP exposure during pregnancy with intra-twin neurodevelopmental differences were more significant in monochorionic diamniotic (MCDA) twins than those in dichorionic diamniotic (DCDA) twins. Conclusions Neurodevelopmental differences in MCDA twins were strongly associated with prenatal phthalate exposure. Our findings warrant further confirmation in longitudinal studies with larger sample sizes.

show abstract

Co-exposure to phenols and phthalates during pregnancy with the difference of body size in twins at one month old

Hong

Xie

et al. 2023

Chemosphere

View full text Add to dashboard Cite

Exposure profiles and predictors of a cocktail of environmental chemicals in Chinese men of reproductive age

Cited by 9 publications

References 49 publications

The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin

The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin

Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age

Co-exposure to phenols and phthalates during pregnancy with the difference of body size in twins at one month old

Contact Info

Product

Resources

About