Exposure Profiles and Human Papillomavirus Infection in Skin Cancer: An Analysis of 25 Genus β-Types in a Population-Based Study

Abstract

An increasing number of studies report that genus beta human papillomaviruses (HPVs) are associated with skin cancer, with suggestions of specificity for squamous cell carcinoma (SCC) of the skin. We have conducted a systematic examination of HPV DNA in tumors from immunocompetent hosts, including SCC and basal cell carcinoma (BCC), using a highly sensitive methodology and population-based samples to test the hypothesis that a differential prevalence of beta-HPVs exists between SCC (n=101) and BCC (n=101) tumors. When testing for all known beta-HPV types, we found no significant difference in HPV prevalence between the two histologies. However, SCC lesions were significantly more likely to be infected with HPV genus beta-species 1 (includes types 5 and 8), than BCC samples (P=0.01); this difference was not observed for any other species. A histologic difference was also observed for those HPV types previously reported to be important in skin cancer (P=0.003). SCC samples showed a higher rate of infectivity (that is, were positive for multiple types) than BCC tumors (P=0.02). These data highlight the potential importance of various genus beta-HPV types, in particular genus beta-species 1 in SCC, and support the hypothesis of a behavioral difference of the virus within the two major histological skin cancers.

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

“…The prevalence of betaPV infection in people without squamous cell carcinoma is now known to exceed 80% (19). Several studies have shown significant associations between the presence of betaPV DNA and squamous cell carcinoma or actinic keratoses (12,18,20,21). The presence of betaPV evokes a serologic response (22) in a proportion of people infected (23).…”

E6 and E7 of human papillomavirus type 18 and UVB irradiation corporately regulate interleukin‐6 and interleukin‐8 expressions in basal cell carcinoma

“…Fair skin colour is also significantly associated with BCC risk (8). Human papillomaviruses (HPVs) have been found to be associated with NMSCs (9)(10)(11)(12)(13). In a previous report, HPV DNA was detected in 27.9% of BCC cases (14).…”

The Clinicopathologic and Molecular Aspects of Non-Melanoma Skin Cancer

“…On the other hand, β papillomaviruses (β-HPVs) also play a role in the tumorigenesis of cSCC as shown by both European and US studies. (49) However, no high-risk types have been identified although there is an association of β species 1 in SCC. Other viruses, such as polyomavirus (MCPyV) have been shown to be causative agent in Merkel cell carcinoma.…”