Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: Correlation of UV filters with use of cosmetics

Schlumpf, Margret; Kypke, Karin; Wittassek, Matthias; Angerer, J.; Mascher, Hermann; Mascher, Daniel; Vökt, Cora; Birchler, Monika; Lichtensteiger, W.

doi:10.1016/j.chemosphere.2010.09.079

Cited by 387 publications

(205 citation statements)

References 43 publications

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“…BuP and BzP were detected less frequently (BuP, 55%; BzP, 37%) in food samples, and HepP was found in only 4 of the 282 samples analyzed (1%). This composition pattern of parabens in food samples is somewhat different from what was reported for human urine, blood, and breast milk from the U.S., in which the concentrations were generally on the order of MeP >> PrP > EtP (Calafat et al, 2010;Frederiksen et al, 2011;Sandanger et al, 2011;Schlumpf et al, 2010;Ye et al, 2006aYe et al, , 2006bYe et al, , 2008. Parabens with longer alkyl chain length possess higher antimicrobial activity, but lower water solubility (Elder, 1984).…”

Section: Paraben Concentrations In Foodscontrasting

confidence: 38%

“…The presence of parabens in urine samples from Spain and Denmark also was documented Frederiksen et al, 2011). Studies have reported the occurrence of parabens in human plasma, serum, and milk at concentrations on the order of a few nanograms per milliliter (Frederiksen et al, 2011;Schlumpf et al, 2010;Wang et al, 2013;Ye et al, 2008). Nevertheless, information on the occurrence of parabens in foodstuffs and other source of human exposure is still scarce.…”

Section: Introductionmentioning

confidence: 99%

“…A few biomonitoring studies have reported the occurrence of parabens in human urine, plasma, serum, and milk (Calafat et al, 2010;Casas et al, 2011;Darbre and Harvey, 2008;Frederiksen et al, 2011;Janjua et al, 2007;Schlumpf et al, 2010;Ye et al, 2006aYe et al, , 2006bYe et al, , 2008. MeP and PrP were found in >96% of urine samples collected from the U.S. (Ye et al, 2006a).…”

Section: Introductionmentioning

confidence: 99%

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Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure

Liao

Chen

Kannan

2013

Environment International

166

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Parabens are alkyl esters of p-hydroxybenzoic acid and are used as antimicrobial preservatives in a range of consumer products, including cosmetics, pharmaceuticals, and foodstuffs. Despite their widespread use, prior to this study, paraben concentrations in foodstuffs from China and human dietary exposure to these chemicals have been unknown. In this study, concentrations of six parabens were determined in 13 categories of food samples (n = 282), including cereals and cereal products, meat, fish and seafood, eggs, dairy products, bean products, fruits, vegetables, cookies, beverages, cooking oils, condiments, and others, collected from nine cities in China. Almost all (detection rate: 99%) food samples contained at least one of the parabens analyzed, and the total concentrations (ΣParabens; sum of six parabens) ranged from below limit of quantification (LOQ) to 2530 ng/g fresh weight, with an overall mean value of 39.3 ng/g. Methyl paraben (MeP), ethyl paraben (EtP), and propyl paraben (PrP) were the major paraben analogs found in foodstuffs, and these compounds accounted for 59%, 24%, and 10%, respectively, of ΣParaben concentrations. Although the mean concentrations of ΣParabens varied among different categories of food items (from 0.839 ng/g in beverages to 100 ng/g in vegetables), the concentrations were not statistically significant among the 13 food categories, including canned foodstuffs. Estimated daily intake (EDI) of parabens was based on the measured concentrations in foods and the corresponding daily food ingestion rates. The mean and 95th percentile values for EDI were 1010 and 3040 ng/kg body weight (bw)/day for adult men and 1060 and 3170 ng/kg bw/day for adult women, respectively.

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Section: Paraben Concentrations In Foodscontrasting

confidence: 38%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure

Liao

Chen

Kannan

2013

Environment International

166

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“…In the United States, 10 the average reported concentrations of parabens were 0.3-3.0 ng mL -1 . Schlumpf et al 32 established the presence of MePB, EtPB and PrPB in 26, 15 and 11% of samples, respectively. A study from Turkey 30 detected parabens in milk samples in a concentration range from 300 to 6000 ng mL -1 .…”

Section: Concentration Of Parabens In Breast Milk Samples From Voluntmentioning

confidence: 99%

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Grecco¹,

Souza²,

Acquaro³

et al. 2018

J. Braz. Chem. Soc.

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A reliable method was developed and validated based on dispersive liquid-liquid microextraction (DLLME) and ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) to determine simultaneously methylparaben (MePB), ethylparaben (EtPB), propylparaben (PrPB), and butylparaben (BuPB) in breast milk samples. A central composite design 2 4 with four independent variables and five levels of variance was used to optimize the DLLME conditions. The DLLME/UHPLC-MS/MS method was linear from 5 (lower limit of quantification, LLOQ) to 100 ng mL -1 (upper limit of quantification, ULOQ). The inter-assay and intra-assay precision values presented coefficients of variation (CVs) lower than 15%, and the relative standard error of the inter-and intra-assay accuracy values was lower than 10.4%. The DLLME/UHPLC-MS/MS method was successfully applied to determine parabens in human milk samples obtained from sixteen volunteer lactating mothers.

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“…In addition, Karlsson et al (2011) reported 23 cases of positive patch and photopatch test reactions in patients with a history of reaction to the anti-inflammatory drug ketoprofen. A study in Switzerland by Schlumpf et al (2010) showed that exposure to UV filters through PCP use was correlated with the presence of chemicals in breast milk and they found that OCR and 4-methylbenzylidene camphor were present in 85.2% of the milk samples.…”

Section: Synthetic Organic Uv Filtersmentioning

confidence: 99%

Cyanobacterial metabolites as a source of sunscreens and moisturizers: a comparison with current synthetic compounds

Derikvand

Llewellyn

Purton

2016

European Journal of Phycology

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Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: Correlation of UV filters with use of cosmetics

Cited by 387 publications

References 43 publications

Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure

Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Cyanobacterial metabolites as a source of sunscreens and moisturizers: a comparison with current synthetic compounds

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