Exposure of Zebrafish (Danio rerio) to Titanium Dioxide Nanoparticle Causes Paraptosis: Evaluation of Ovarian Follicle Ultrastructure

Akbulut, Cansu; Kotil, Tuğba; Öztürk, Burcu; Yön, Nazan Deniz

doi:10.17582/journal.pjz/2017.49.3.1077.1083

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…To this end, adults were treated for 5 days with different doses of nanoparticles (1, 2, and 4 mg/L). The analysis was performed by using both histological staining (hematoxylin and eosin on paraffin sections) and TEM [69]. Several toxic effects of TiO 2 NPs were observed in the ovaries.…”

Section: Effects Of Titanium Dioxide Nanoparticles On Adultsmentioning

confidence: 99%

Effects of Metal Oxide Nanoparticles in Zebrafish

d’Amora

Schmidt

Konstantinidou

et al. 2022

Oxidative Medicine and Cellular Longevity

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Metal oxide nanoparticles (MO NPs) are increasingly employed in many fields with a wide range of applications from industries to drug delivery. Due to their semiconducting properties, metal oxide nanoparticles are commonly used in the manufacturing of several commercial products available in the market, including cosmetics, food additives, textile, paint, and antibacterial ointments. The use of metallic oxide nanoparticles for medical and cosmetic purposes leads to unavoidable human exposure, requiring a proper knowledge of their potentially harmful effects. This review offers a comprehensive overview of the possible toxicity of metallic oxide nanoparticles in zebrafish during both adulthood and growth stages, with an emphasis on the role of oxidative stress.

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Section: Effects Of Titanium Dioxide Nanoparticles On Adultsmentioning

confidence: 99%

Effects of Metal Oxide Nanoparticles in Zebrafish

d’Amora

Schmidt

Konstantinidou

et al. 2022

Oxidative Medicine and Cellular Longevity

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show abstract

“…Bellingeri et al (2019) also found that exposure to Cu and PS-MPs resulted in the formation of multinucleated cells and abnormalities in the mitotic process by observing cell morphology. Additionally, the exposure of other NPs (TiO 2 ) inhibited the oogenesis of zebrafish and led to cell death, which was manifested by chromatin condensation, mitochondrial swelling and mitotic catastrophe (Akbulut et al, 2017). Therefore, we believe that the exposure of PS-MPs and Cu-NPs would hinder the transition of different phases in the cell cycle by inhibiting the expression of MCM complex and cyclins, thereby affecting the normal operation of the cell cycle and the failure of cell proliferation; it also inhibited the normal formation of spindles and spindle assembly checkpoints, which would lead to abnormal chromosome arrangement and inaccurate separation of genetic materials, and induce mitotic catastrophe.…”

Section: Cell Cyclementioning

confidence: 99%

Impact and Molecular Mechanism of Microplastics on Zebrafish in the Presence and Absence of Copper Nanoparticles

et al. 2021

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The adverse effects of microplastics (MPs) in aquatic environments have attracted increasing attention and posed health risks along with nanomaterials. Therefore, the toxic effects of polystyrene microplastics (PS-MPs) with different particle sizes (0.07, 0.7 and 7 μm) on zebrafish in the presence and absence of copper nanoparticles (Cu-NPs) were evaluated. The acute toxicity of MPs on zebrafish was 7 μm > 0.07 μm > 0.7 μm. Both 0.07 and 7 μm MPs acted on chromosomes and significantly affected cell cycle process by affecting palmitoyl hydrolase activity; while 0.7 μm MPs acted on extracellular space and significantly affected the activity of endopeptidase inhibitor to affect the cholesterol transport. And 0.07 and 7 μm MPs dominantly affected “cell cycle” pathway by inhibiting DNA replication, delaying the progression of S phase and G2/M phase, and affecting the accurate arrangement and separation of chromosomes; while the 0.7 μm MPs activated numerous platelets to aggregate and adhere in damaged parts, enhanced the coagulation function of platelets, and promoted the formation of fibrin clots, thus abnormally activating the “hemostasis” pathway. The presence of Cu-NPs significantly changed the toxicity-related pathways induced by 7 μm MPs from “cell cycle” into “hemostasis,” but not for the smaller-sized MPs (0.07 and 0.7 μm). The combined exposure of Cu-NPs and 7 μm MPs acted on the extracellular region and significantly affected cholesterol transport by affecting the activity of cholesterol transporters. This study provides theoretical insights for the health risks of MPs to aquatic species and even humans in the actual ecosystem.

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Exposure of Zebrafish (Danio rerio) to Titanium Dioxide Nanoparticle Causes Paraptosis: Evaluation of Ovarian Follicle Ultrastructure

Cited by 2 publications

References 10 publications

Effects of Metal Oxide Nanoparticles in Zebrafish

Effects of Metal Oxide Nanoparticles in Zebrafish

Impact and Molecular Mechanism of Microplastics on Zebrafish in the Presence and Absence of Copper Nanoparticles

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