Exposure of mosquito (Aedes aegypti) larvae to the water extract and lectin-rich fraction of Moringa oleifera seeds impairs their development and future fecundity

Silva, Livia Lais de Santana; Fernandes, Kenner Morais; Miranda, Franciane Rosa; Silva, Stella Cristina Cabral; Coelho, Luana Cassandra Breitenbach Barroso; Navarro, Daniela Maria do Amaral Ferraz; Napoleão, Thiago Henrique; Martins, Gustavo Ferreira; Paiva, Patrícia Maria Guedes

doi:10.1016/j.ecoenv.2019.109583

Cited by 17 publications

(14 citation statements)

References 33 publications

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“…The deleterious effects of lectins on the reproductive activities of invertebrates have been described previously. For example, Silva et al [35] reported that larvae of Aedes aegypti exposed to lectin preparations from Moringa oleifera seeds developed into adult females that produced eggs with reduced viability.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Molluscicidal, Artemicidal and Cytotoxic Activities of the Lectin from Opuntia ficus-indica Cladodes (OfiL)

Santana

Albuquerque

Pontual

et al. 2020

AJRB

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Background: Biomphalaria glabrata is an intermediate host for the larvae of Schistosoma mansoni, which is distributed widely in the tropics. B. glabrata control is important to minimize the spread of schistosomiasis and natural compounds have been sought for use against this disease. The Artemia salina bench-top bioassay has been used to investigate the ecotoxicity of many natural compounds, and its results also correlate well with the in vitro cytotoxicity of natural compounds to tumor cells. Aims: To evaluate deleterious effects of the Opuntia ficus-indica lectin (OfiL) on B. glabrata, A. salina and human cancer cell lines. Methods: OfiL was isolated following a previously established protocol. The effects of OfiL on B. glabrata were investigated by determining survival of adults as well as development and hatching of embryos. The concentration required to kill 50% (LC50) of A. salina nauplii was determined. The cytotoxicity was determined using the human cell lines Hep-2 (human larynx epidermoid carcinoma), NCI-H292 (human lung mucoepidermoid carcinoma) and K562 (chronic myelocytic leukemia). Results: The development of most embryos (92.5–97.5%) treated with 1, 10 and 100 µg/mL of OfiL was found to be delayed, and dead (2.2–3.3%) and malformed (0.3–5.2%) embryos were also observed. OfiL did not kill B. glabrata adults, but a high percentage (30–45%) of the embryos generated by snails incubated with the lectin exhibited malformations. OfiL exhibited toxicity against A. salina (LC50: 61.02 µg/mL) but did not display cytotoxicity against the tumor cell lines evaluated. Conclusion: In conclusion, this study showed that OfiL can be a tool for schistosomiasis control that acts by impairing the viability of B. glabrata eggs and the fecundity of adult snails.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the Molluscicidal, Artemicidal and Cytotoxic Activities of the Lectin from Opuntia ficus-indica Cladodes (OfiL)

Santana

Albuquerque

Pontual

et al. 2020

AJRB

Self Cite

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“…No trabalho realizado por Dias et al, (2017) As lectinas são proteínas abundantes nos vegetais e possuem ação inseticida contra o A. aegypti (COELHO et al, 2017;SILVA et al, 2019b;CAVALCANTI et al, 2021 ). As sementes de Moringa oleífera Lam, são provavelmente as mais bem estudadas no combate ao A. aegypti, pois são ricas em lectinas e diversos trabalhos atestaram excelentes resultados dos extratos das sementes desta planta contra o A. aegypti, o que a torna forte candidata para ser usada como inseticida natural (Silva et al, 2019a).…”

Section: O Potencial Das Sementes No Combate Ao Vetorunclassified

“…Outra desvantagem da utilização dos inseticidas sintéticos diz respeito ao crescente surgimento de organismos resistentes a estes produtos, devido ao uso prolongado, com concentrações cada vez maiores dos mesmos (AFFELDT et al, 2016;POSSEL, 2019;SILVA et al, 2019a). Sendo assim, é importante buscar alternativas de combate ao A.…”

Section: Introductionunclassified

Desenvolvimento De Oficinas Para Confecção De Produtos Sustentáveis Utilizando Lona De Banner Durante a Pandemia Da Covid-19

Santos¹,

Santos²,

Costa³

et al. 2021

Agenda Da Sustentabilidade No Brasil: Conhecimentos Teóricos, Metodológicos E Empíricos

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“…The Aedes aegypti mosquito is the main vector of the arboviruses causing dengue, chikungunya, yellow fever, and Zika. Among these diseases, only yellow fever has a widely available vaccine; the Sanofi-Pasteur group produces a vaccine for dengue, but it is not available for mass vaccination . Therefore, there remain substantial economic and health service burdens in regions where arbovirus-borne diseases are endemic .…”

Section: Introductionmentioning

confidence: 99%

Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

Rogério

Abrantes

Oliveira

et al. 2022

ACS Appl. Bio Mater.

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The most important arboviruses are those that cause dengue, yellow fever, chikungunya, and Zika, for which the main vector is the Aedes aegypti mosquito. The use of repellents is an important way to combat mosquito-borne pathogens. In this work, a safe method of protection employing a repellent was developed based on a slow release system composed of zein nanoparticles containing the active agents icaridin and geraniol incorporated in a cellulose gel matrix. Analyses were performed to characterize the nanoparticles and the gel formulation. The nanoparticles containing the repellents presented a hydrodynamic diameter of 229 ± 9 nm, polydispersity index of 0.38 ± 0.10, and zeta potential of +29.4 ± 0.8 mV. The efficiencies of encapsulation in the zein nanoparticles exceeded 85% for icaridin and 98% for geraniol. Rheological characterization of the gels containing nanoparticles and repellents showed that the viscoelastic characteristic of hydroxypropylmethylcellulose gel was preserved. Release tests demonstrated that the use of nanoparticles in combination with the gel matrix led to improved performance of the formulations. Atomic force microscopy analyses enabled visualization of the gel network containing the nanoparticles. Cytotoxicity assays using 3T3 and HaCaT cell cultures showed low toxicity profiles for the active agents and the nanoparticles. The results demonstrated the potential of these repellent systems to provide prolonged protection while decreasing toxicity.

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Exposure of mosquito (Aedes aegypti) larvae to the water extract and lectin-rich fraction of Moringa oleifera seeds impairs their development and future fecundity

Cited by 17 publications

References 33 publications

Evaluation of the Molluscicidal, Artemicidal and Cytotoxic Activities of the Lectin from Opuntia ficus-indica Cladodes (OfiL)

Evaluation of the Molluscicidal, Artemicidal and Cytotoxic Activities of the Lectin from Opuntia ficus-indica Cladodes (OfiL)

Desenvolvimento De Oficinas Para Confecção De Produtos Sustentáveis Utilizando Lona De Banner Durante a Pandemia Da Covid-19

Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

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