Exposure of Coke-Oven Workers to Polycyclic Aromatic Hydrocarbons Based on Biological Monitoring Results

Mielzynska, Danuta; Braszczyńska, Z; Siwinska, Ewa; Smolik, E.; Bubak, A.; Sokal, J.A.

doi:10.1202/0002-8894(1997)058<0661:eocwtp>2.0.co;2

Cited by 6 publications

(5 citation statements)

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“…Our analytic method measured 14 hydroxylated metabolites in urine. The most common PAH metabolite used for biomonitoring exposure is 1-hydroxypyrene, having been studied in a variety of environmental settings (Bouchard et al 2001;Gilbert and Viau 1997;Gundel et al 1996;Scherer et al 2000;Viau et al 2000), aluminum refining (Levin et al 1995;Ny et al 1993;Ovrebo et al 1995b;Van Schooten et al 1995), and coke production (Mielynska et al 1997;Ovrebo et al 1995a;Pan et al 1998;van Delft et al 2001;VanRooij et al 1993;Wu et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Edelman

Osterloh

Pirkle

et al. 2003

Environ Health Perspect

117

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The collapse of the World Trade Center (WTC) on 11 September 2001 exposed New York City firefighters to smoke and dust of unprecedented magnitude and duration. The chemicals and the concentrations produced from any fire are difficult to predict, but estimates of internal dose exposures can be assessed by the biological monitoring of blood and urine. We analyzed blood and urine specimens obtained from 321 firefighters responding to the WTC fires and collapse for 110 potentially fire-related chemicals. Controls consisted of 47 firefighters not present at the WTC. Sampling occurred 3 weeks after 11 September, while fires were still burning. When reference or background ranges were available, most chemical concentrations were found to be generally low and not outside these ranges. Compared with controls, the exposed firefighters showed significant differences in adjusted geometric means for six of the chemicals and significantly greater detection rates for an additional three. Arrival time was a significant predictor variable for four chemicals. Special Operations Command firefighters (n = 95), compared with other responding WTC firefighters (n = 226), had differences in concentrations or detection rate for 14 of the chemicals. Values for the Special Operations Command firefighters were also significantly different from the control group values for these same chemicals and for two additional chemicals. Generally, the chemical concentrations in the other firefighter group were not different from those of controls. Biomonitoring was used to characterize firefighter exposure at the WTC disaster. Although some of the chemicals analyzed showed statistically significant differences, these differences were generally small.

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Section: Discussionmentioning

confidence: 99%

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Edelman

Osterloh

Pirkle

et al. 2003

Environ Health Perspect

117

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“…Although some studies for urinary mutagenicity reported null or equivocal findings (Clonfero et al, 1995;Miely nska et al, 1997;Venier et al, 1985), others found positive associations between urinary mutagenicity and PAH exposure, such as in bus drivers (Hansen et al, 2004), coke oven workers (Simioli et al, 2004;Siwi nska et al, 2004), rubber manufacturers (Peters et al, 2008), policeman (Ledda et al, 2018), and municipal firefighters (Keir et al, 2017).…”

Section: Indoor Coal Combustion Emissionsmentioning

confidence: 99%

Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust

Wong

Vermeulen

Dai

et al. 2021

Environ and Mol Mutagen

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Urinary mutagenicity reflects systemic exposure to complex mixtures of genotoxic/ carcinogenic agents and is linked to tumor development. Coal combustion emissions (CCE) and diesel engine exhaust (DEE) are associated with cancers of the lung and other sites, but their influence on urinary mutagenicity is unclear. We investigated associations between exposure to CCE or DEE and urinary mutagenicity. In two separate cross-sectional studies of nonsmokers, organic extracts of urine were evaluated for mutagenicity levels using strain YG1041 in the Salmonella (Ames) mutagenicity assay. First, we compared levels among 10 female bituminous (smoky) coal users from Laibin, Xuanwei, China, and 10 female anthracite (smokeless) coal users. We estimated exposure-response relationships using indoor air concentrations of two

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“…30). The TA98 strain was chosen because this strain has been recommended in detecting the exposure to polycyclic aromatic hydrocarbons (31). Various doses of extract between 0.5 and 5 mL of urine equivalent were assayed.…”

Section: Urinary Acute Toxicity Test Using Microtox Bioassaymentioning

confidence: 99%

Repeated Measurements of Urinary Methylated/Oxidative DNA Lesions, Acute Toxicity, and Mutagenicity in Coke Oven Workers

Chao¹,

Wang

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We conducted a repeated-measures cohort study of coke oven workers to evaluate the relationships between the traditional exposure biomarker, urinary 1-hydroxypyrene (1-OHP), and a series of biomarkers, including urinary 8-oxo-7,8-dihydro-2 ¶-deoxyguanosine (8-oxodG), N7-methylguanine (N7-MeG), acute toxicity, and mutagenicity. A total of eight spot urine samples were collected from each high-exposed (at topside oven area) and low-exposed workers (at side oven area) during the whole working cycle, which consisted of 6 consecutive days of working followed by 2 days off. Our results showed that the high-exposed workers had significantly higher urinary levels of 1-OHP, 8-oxodG, and N7-MeG compared with the low-exposed workers. Acute toxicity and mutagenicity of urine were also found to be markedly increased in the high-exposed workers, as determined by Microtox assay and Ames test, respectively. Multivariate regressions analysis revealed that the urinary 8-oxodG, N7-MeG, or acute toxicity was significantly correlated with 1-OHP concentrations. Overall, the present study showed that exposure to coke oven emissions increased oxidatively damaged DNA products and mutagenicity of urine, and for the very first time, such exposure was also found to increase DNA methylation and urinary acute toxicity. The potential source of methylating agents in coke oven emissions warrants further investigation. Additionally, with repeated measurements, the pattern of time course for urinary 1-OHP was found to be different from those of 8-oxodG and N7-MeG, as well as acute toxicity and mutagenicity. This finding implies that the single measurement that was often conducted in occupational healthy investigations should be used with certain precautions, because single measurement may fail to provide the proper information of interest. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3381 -9)

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Exposure of Coke-Oven Workers to Polycyclic Aromatic Hydrocarbons Based on Biological Monitoring Results

Cited by 6 publications

References 0 publications

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse.

Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust

Repeated Measurements of Urinary Methylated/Oxidative DNA Lesions, Acute Toxicity, and Mutagenicity in Coke Oven Workers

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