Exposure of Brazilian soil and groundwater to pollution by coccidiostats and antimicrobial agents used as growth promoters

Arenas, Alejandro Yopasá; Fostier, Anne Hélène

doi:10.1016/j.scitotenv.2018.06.338

Cited by 23 publications

(9 citation statements)

References 17 publications

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“…In addition, extensive use of maduramicin and other ionophores in the livestock production industry increased the environmental release and posed potential risk to ecology safety and public human health in recent years [20,33]. Previous studies show the occurrence of maduramicin and ionophore antibiotics in manure, surface water, sediments, and many other environmental compartments [31,32,[40][41][42]. As emerging contaminants, the predicted concentrations in all environmental compartments and measured environmental concentrations in sediments are higher than predicted no-effect concentrations, suggesting a potential environmental risk of ionophores [33].…”

Section: Discussionmentioning

confidence: 99%

Ionophore Toxin Maduramicin Produces Haff Disease-Like Rhabdomyolysis in a Mouse Model

Gao

Song

Zuo

et al. 2020

IJERPH

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Maduramicin is a toxic ionophore antibiotic that is isolated from Streptomyces, frequently occurring in an aquatic environment. To understand the potential role of maduramicin in crayfish consumption related Haff disease, a mouse model was established in this study. Two exposure routes of maduramicin in the abdominal muscle and the hepatopancreas tissue homogenates of crayfish were given intragastrically to mice in different doses for seven days. Action changes, clinical symptoms, feed consumption, body weight, blood biochemistry, and histopathology examination of mice were observed and analyzed. In the natural exposure group, relatively low concentration of maduramicin in crayfish muscle and hepatopancreas had no obvious effects on mental state, body weight, blood biochemical indexes, or histologic appearance. However, in the artificial exposure group, with increasing concentrations, maduramicin in crayfish muscle and hepatopancreas homogenates both induced mental sluggishness and weight loss of mice. Blood biochemical examination showed that 3.5 mg·kg−1 and 7 mg·kg−1 maduramicin in crayfish tissue homogenates significantly increased levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), and creatine kinase (CK). Additionally, histopathological examination showed that multiple organs were damaged by maduramicin, including degeneration of liver cells, shedding of renal epithelial cells, and disturbance and partial lysis of myocardial and skeletal muscle filaments in the mice. In summary, maduramicin may not cause Haff disease through contamination of the aquatic environment under normal conditions. Maduramicin can be used as a potential toxin tool to establish a rhabdomyolysis disease animal model for drug development.

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Section: Discussionmentioning

confidence: 99%

Ionophore Toxin Maduramicin Produces Haff Disease-Like Rhabdomyolysis in a Mouse Model

Gao

Song

Zuo

et al. 2020

IJERPH

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“…The standard biodegradation assay was performed in 100 mL MM containing 10 mg L −1 monensin (0.1% Tween 20) at 30 °C, pH 7.0 and the initial inoculum was added at 3% concentration (v/v). Different temperatures (10, 20, 30, 40 and 50 °C), pH values (4, 5, 6, 7, 8 and 9), and initial monensin concentrations (5, 10, 25, 50 and 100 mg L −1 ) were tested for their effect on monensin degradation. Only one condition was altered at a time for each assay.…”

Section: Methodsmentioning

confidence: 99%

“…It is released into agricultural fields when animal manure is used as fertilizer. Owing to its long‐term use and high mobility in organic manure, soil, surface water and groundwater, its residual amount in some environments has greatly exceeded the maximum allowed concentrations . Monensin is toxic to zooplankton, protozoa, fungi and Gram‐positive bacteria, and even to higher organisms such as earthworm and fish .…”

Section: Introductionmentioning

confidence: 99%

Monensin biodegradation pathway and role of epoxide hydrolase in Stenotrophomonas maltophilia DM‐2

Wan

et al. 2020

J of Chemical Tech & Biotech

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BACKGROUND: Monensin is widely used in livestock and poultry production to promote animal growth and control coccidiosis. Most monensin is excreted as unchanged parent compounds via feces. However，monensin is very stable and difficult to degrade in the environment, and is potentially risky for the health of wildlife and humans. To date, the biodegradation process of monensin by bacteria and its mechanism is unclear. In this study, we found that a Stenotrophomonas maltophilia DM-2 strain isolated from chicken manure could effectively degrade monensin.RESULT: The optimum temperature and pH for DM-2 to degrade monensin were 40°C and pH 7.0. A potential degradation pathway of monensin was proposed based on the identification and characterization of two new monensin metabolic intermediates by liquid chromatography quadrupole time-of-flight mass spectroscopy. In addition, an inducible monensin-degrading activity was present in DM-2. A soluble epoxide hydrolysis (sEH) gene highly expressed in the DM-2 on day 3 and 6 under monensin stress, which was not observed in the DM-2 without monensin stress. When a specific inhibitor TPPU (1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea) of sEH was added into the cell-free extract, the degradation of monensin was inhibited.CONCLUSION: Strain DM-2 can biodegrade monensin by soluble epoxy hydrolase and produce two new intermediates. To our knowledge, this is the first report of the degradation of monensin by Stenotrophomonas strains. The novel metabolic pathways of monensin which we found may provide new insight into the environmental fate of monensin.

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“…However, the European Union has banned GPAs, even food-grade antibiotics, because of the possible risk of human pathogenic bacteria developing greater resistance. In other countries in Latin America, efforts are being made to prohibit their use [38–40]. Notably, the growth promotion mechanisms of GPAs are still unknown, yet different hypotheses have been proposed to explain GPAs mechanisms.…”

Section: Effect Of Oxidative Stress On Carcass and Meat Qualitymentioning

confidence: 99%

Use of natural ingredients in Japanese quail diet and their effect on carcass and meat quality — A review

Vargas-Sánchez

Ibarra-Arias²,

Torres-Martínez

et al. 2019

Asian-Australas J Anim Sci

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The present paper reviews the findings of different research studies on the effect of natural ingredients in the Japanese quail (Coturnix coturnix japonica) diet on carcass characteristics and meat quality. The results show a relationship between the type and concentration of ingredients used in diets and carcass characteristics and meat quality. The inclusion of medicinal herbs (thyme, black seed, and mint), plants (canola), seeds (chickpea), spices (cinnamon and coriander), worms (earthworms), bee products (propolis), phytochemicals (lycopene), and edible fungi (common mushrooms) in the diet improved carcass quality characteristics compared to the control diets (basal diets). The inclusion of medicinal herbs (spearmint and green tea), spices (cinnamon), vegetables (tomato), plants (verbena and canola), seeds (marijuana), and edible fungi (oyster mushrooms) improved meat quality. In conclusion, the use of ingredients of natural origin in the diet of Japanese quail improves carcass quality characteristics and meat quality.

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Exposure of Brazilian soil and groundwater to pollution by coccidiostats and antimicrobial agents used as growth promoters

Cited by 23 publications

References 17 publications

Ionophore Toxin Maduramicin Produces Haff Disease-Like Rhabdomyolysis in a Mouse Model

Ionophore Toxin Maduramicin Produces Haff Disease-Like Rhabdomyolysis in a Mouse Model

Monensin biodegradation pathway and role of epoxide hydrolase in Stenotrophomonas maltophilia DM‐2

Use of natural ingredients in Japanese quail diet and their effect on carcass and meat quality — A review

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