Exposure levels of organophosphate pesticides in Japanese diapered children: Contributions of exposure-related behaviors and mothers’ considerations of food selection and preparation

Oya, Naoko; Ito, Yuki; Ebara, Takeshi; Kato, Sayaka; Hioki, Keisuke; Aoi, Arisa; Ueyama, Jun; Oguri, Tomoko; Shoji, Naoto; Sugiura‐Ogasawara, Mayumi; Saitoh, Shinji; Kamijima, Michihiro

doi:10.1016/j.envint.2019.105294

Cited by 16 publications

(8 citation statements)

References 33 publications

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“…This can be explained by the fact that urine samples were collected from June to September, which is when crop cultivation starts, in the present study, but in February, which is after harvesting, in the previous study [41,42]. Similarly, there were seasonal differences in previous studies in Japan and the Netherlands, but they investigated dimethyl moieties instead of diethyl moieties, which are more potent [51][52][53]. By contrast, a previous study of Thai children reported no significant difference in DAPs between seasons in which pesticide use was low and high [27].…”

Section: Urinary Dap and Neo/m Concentrationsmentioning

confidence: 57%

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Suwannarin

Prapamontol

Isobe

et al. 2021

IJERPH

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Exposure to insecticides may result in various health problems. This study investigated the association between haematological parameters and exposure to a mixture of organophosphate (OP) and neonicotinoid (NEO) insecticides among male farmworkers in Fang district, Chiang Mai province, northern Thailand. Concentrations of urinary dialkylphosphates, non-specific metabolites of OPs, and NEOs and their metabolites and haematological parameters were measured in 143 male farmworkers. The Bayesian kernel machine regression model was employed to evaluate the associations. Exposure to a mixture of insecticides was significantly associated with the mean corpuscular haemoglobin concentration (MCHC) when the concentrations of all the compounds and their metabolites were at the 60th percentile or higher compared with the 50th percentile. Furthermore, exposure to clothianidin (CLO) showed a decreasing association with MCHC when all the other insecticides were at their mean concentrations. CLO was the most likely compound to reduce MCHC, and this was confirmed by sensitivity analysis. These findings suggest that exposure to NEO insecticides, especially CLO, affects the haematological status relating to haemoglobin parameters.

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Section: Urinary Dap and Neo/m Concentrationsmentioning

confidence: 57%

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Suwannarin

Prapamontol

Isobe

et al. 2021

IJERPH

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“…62−64 The participants in these studies were infants, toddlers, and children (3 months to 3 years), and the sample size was relatively small (113, 15, and 171 in Swiss, Chinese, and Korean studies, respectively). We have markedly improved the urine extraction procedure in terms of time and cost 46,47 and also validated all of the parameters of the present method using DESU, following the analytical guidelines formulated by the authorities. The detection frequencies of the metabolites in our method were high with the finest LOD values.…”

Section: Urinary Concentrations Of Phthalate Metabolitesmentioning

confidence: 91%

“…The protocols of diaper collection and urine extraction previously described were followed. , Synthetic urine was manually poured onto the designated diaper and extracted similarly. The diaper-extracted synthetic urine (DESU) with the spiked standards was used for validation.…”

Section: Methodsmentioning

confidence: 99%

Quantitative Measurement of Phthalate Exposure Biomarker Levels in Diaper-Extracted Urine of Japanese Toddlers and Cumulative Risk Assessment: An Adjunct Study of JECS Birth Cohort

Mohanto

Ito

Kato

et al. 2022

Environ. Sci. Technol.

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Phthalate exposure monitoring and risk assessment in non-toilet-trained children are rarely reported. This adjunct study of the Japan Environment and Children’s Study assessed cumulative health risks in 1.5-year-old toddlers in the Aichi regional subcohort by biomonitoring 16 urinary metabolites of eight phthalate plasticizers. Overnight urine was extracted from toddlers’ diapers (n = 1077), and metabolites were quantified using ultraperformance liquid chromatography coupled with tandem mass spectrometry. The analyses’ quality was assured by running quality control samples. The highest geometric mean concentration was found for mono-(2-ethyl-5-carboxypentyl) phthalate, followed by mono-isobutyl phthalate (23 and 21 μg/L, respectively). Di-2-ethylhexyl phthalate (DEHP) and di-butyl phthalate exhibited higher risks [hazard quotient (HQ) > 1] than the cutoff level in a small proportion of toddlers; 8 and 14% of toddlers were at cumulative risk of multiple phthalates beyond the cutoff level [hazard index, (HI) > 1], based on the tolerable daily intake of the European Food Safety Authority and the United States Environmental Protection Agency Reference Dose. HI > 1 for antiandrogenicity in creatinine-unadjusted and -adjusted estimations were exhibited by 36 and 23% of the children, respectively. Thus, identifying exposure sources and mitigating exposure are necessary for risk management. Additionally, continuous exposure assessment and evaluation of health outcomes, especially antiandrogenic effects, are warranted.

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“…There are no nationally representative biomonitoring data for OPPs in Japan. A few studies conducted in the last five years showed that metabolites of OPPs were detected in Japanese women and children [ 14 , 20 ], including pregnant women [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Nishihama

Nakayama

Isobe

et al. 2021

IJERPH

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Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose10.

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Exposure levels of organophosphate pesticides in Japanese diapered children: Contributions of exposure-related behaviors and mothers’ considerations of food selection and preparation

Cited by 16 publications

References 33 publications

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Quantitative Measurement of Phthalate Exposure Biomarker Levels in Diaper-Extracted Urine of Japanese Toddlers and Cumulative Risk Assessment: An Adjunct Study of JECS Birth Cohort

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

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