Exposure in the tobacco fields: Genetic damage and oxidative stress in tobacco farmers occupationally exposed during harvest and grading seasons

Dalberto, Daiana; Alves, Jodel; Garcia, Ana Letícia Hilário; Souza, Melissa Rosa de; Abella, Angélica Pich; Thiesen, Flávia Valladão; Salvador, Mirian; Branco, Cátia Santos; Marroni, Norma Possa; Bona, Silvia Regina; Schemitt, Elizângela Gonçalves; Silva, Fernanda Rabaioli da; Silva, Juliana da

doi:10.1016/j.mrgentox.2022.503485

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…(25,26) Por último, la hibridación in situ por fluorescencia se utilizó para detectar y evaluar la inestabilidad cromosómica y la heterogeneidad clonal debido a la exposición química de los pesticidas. (27) Además, es posible observar una clara relación entre la exposición laboral a plaguicidas y la aparición de diversas enfermedades potencialmente severas. En particular, se ha demostrado que la exposición a plaguicidas puede aumentar el riesgo de desarrollar cáncer, trastornos neurológicos, trastornos reproductivos, trastornos endocrinos, trastornos de comportamiento, trastornos autoinmunes y enfermedades cardiovasculares.…”

Section: Resultsunclassified

“…Además, hay que tener en cuenta que la sensibilidad limitada para detectar pequeñas variaciones cromosómicas puede llevar a resultados falsos negativos, además requiere una cantidad significativa de material celular para analizarlo, depende de marcadores específicos para localizar regiones cromosómicas particulares y reactivos costosos. (19,27) • La técnica de aberración cromosómica (AC) en el artículo revisado es útil para evaluar la genotoxicidad de agentes químicos tóxicos, radiación y otros. Sin embargo, se requiere muestras de sangre apropiadas, controlar los parámetros de cultivo y detectar cambios mínimos en la estructura cromosómica, por lo que puede ser costosa y complicada de llevar a cabo, por lo que se requiere personal altamente capacitado para realizarlo, a esto se suma que la estandarización entre laboratorios puede afectar la confiabilidad de los resultados.…”

Section: Discussionunclassified

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Systematization of research on the incidence of pesticides in people, use of biomarkers

Maldonado Mariño,

Siza Saquinga,

Guato Canchinia

et al. 2024

Data and Metadata

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Currently the use of pesticides in agriculture has expanded in the search for greater productivity. These products can harm people's health in various ways. These effects can be captured through the use of genotoxicity biomarkers. The objective of this research is to systematize studies on biomarkers of genotoxicity of people exposed to pesticides in South America. The PRISMA method was applied to determine the studies to be analyzed. 15 documents met the inclusion criteria. Among the adverse health effects perceived in studies are neurological, respiratory, dermatological and endocrine disorders, as well as an increased risk of cancer. The main biomarkers identified are the comet assay, the cytokinesis blockade micronucleus assay, and the buccal cytoma micronucleus assay. Polymerase chain reaction, chromosomal aberrations, flow cytometry, and fluorescence in situ hybridization were also taken into account. Limitations were determined by biomarker. The usefulness of using multiple biomarkers is highlighted for a more complete and precise evaluation of pesticide exposure and genotoxic damage in agricultural workers in South America. The establishment of protective measures for workers against the use of pesticides and opting for the use of pesticides of biological origin will contribute to the preservation of people's health.

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Section: Resultsunclassified

Section: Discussionunclassified

Systematization of research on the incidence of pesticides in people, use of biomarkers

Maldonado Mariño,

Siza Saquinga,

Guato Canchinia

et al. 2024

Data and Metadata

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“…Exposure to DDT in utero is also associated with an increased risk of breast cancer [27]. Tobacco farmers may experience compromised deoxyribonucleic acid (DNA) integrity associated with enhanced oxidative stress levels during the harvest and grading period [28]. Pesticide-exposed workers have more DNA damage revealed by the comet assay and micronucleus test than do non-exposed workers [29].…”

Section: Introductionmentioning

confidence: 99%

Qualitative Study to Explore the Occupational and Reproductive Health Challenges among Women Tobacco Farm Laborers in Mysore District, India

Ravi,

Muralidhar,

Ngaybe

et al. 2024

IJERPH

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Tobacco farm laborers are primarily women and children working for very low wages. The aim of this study was to explore occupational and reproductive health challenges faced by women tobacco farm laborers in Mysore District, India. We conducted interviews and six focus group discussions among 41 women tobacco farm laborers. Codes and themes were generated based on deductive and inductive approaches using the socioecological model. Participants reported symptoms of green tobacco sickness including headaches, back pain, gastric problems, weakness, and allergies during menstruation, pre-natal, and post-natal periods. Participants had poor awareness about the health effects of tobacco farming, and there were gender inequalities in wages and the use of personal protective equipment. Participants received support from family and community health workers during their pregnancy and post-natal period. Women reported wanting maternity benefits from the tobacco board, as well as monetary support and nutritional supplements. There is a need for health education about the environmental dangers of tobacco among farm laborers, and more supportive policies for women farmworkers during pregnancy and post-natal periods.

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Editorial: Genetic toxicology in Brazil

Silva

Brucker

García

2023

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Exposure in the tobacco fields: Genetic damage and oxidative stress in tobacco farmers occupationally exposed during harvest and grading seasons

Cited by 6 publications

References 41 publications

Systematization of research on the incidence of pesticides in people, use of biomarkers

Systematization of research on the incidence of pesticides in people, use of biomarkers

Qualitative Study to Explore the Occupational and Reproductive Health Challenges among Women Tobacco Farm Laborers in Mysore District, India

Editorial: Genetic toxicology in Brazil

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