Exposure Effect to Glyphosate Based Herbicide - Roundup Original ® - And Nutritional Therapy With Folic Acid and Selenium on Bullfrog (Lithobates Catesbeianus, Shaw - 1802) Cardiac Hytogenesis

Lima, Igor Barbosa; Machado, Jéssica Rayssa; Machado, Jéssica Fernanda Fonseca; Rivaroli, Luciano

doi:10.24021/raac.v17i1.5336

Cited by 3 publications

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“…Moreover, the acute toxicity of glyphosate-based pesticides, as Atanor®, Credit®, Glifloglex®, and Roundup Ultra Max®, was informed in the range of 19.4 mg/L and 78.18 mg/L (Brodeur et al 2014;Soloneski et al 2016). It has been previously demonstrated that glyphosate causes oxidative stress, inhibits the action of key enzymes for regulation of cell cycle, and produces genotoxic damage on amphibian larvae (Carvalho et al 2020;Lima et al 2020). Toxicity studies of 2,4-D on amphibians have shown that the herbicide inhibits oocyte maturation (LaChapelle et al 2007;Stebbins-Boaz et al 2004) and has teratogenic effects on Xenopus laevis (Morgan et al 1996) and Rhinella arenarum, one of the most susceptible amphibian species during the embryo-larval period (Aronzon et al 2011).…”

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confidence: 99%

Synergistic effects of glyphosate- and 2,4-D-based pesticides mixtures on Rhinella arenarum larvae

Peluso

Lanuza

Coll

et al. 2021

Environ Sci Pollut Res

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Glyphosate and 2,4-D are two herbicides commonly used together. Since there is little information about the interactions between these pesticides, the aim of this study was to evaluate the single and joint lethal toxicity of the glyphosate-based herbicide (GBH) ATANOR® (43.8% of glyphosate, isopropylamine salt) and the 2,4-D-based herbicide (2,4-DBH) Así Max 50® (602000 mg/L of 2,4-D) on Rhinella arenarum larvae. Equitoxic and non-equitoxic mixtures were prepared according to the recommendation for their combination and analyzed with a fixed ratio design at different exposure times and levels of lethality (LC10, LC50, and LC90). GBH (504h-LC50=38.67 mg ae/L) was significantly more toxic than 2,4-DBH (504h-LC50=250.31 mg ae/L) and their toxicity was time-dependent. At 48h, the equitoxic mixture toxicity was additive and from the 96h was antagonistic at LC10 and LC50 effect level. The non-equitoxic mixture toxicity was additive at LC10 effect level from the 48h to the 168h, and synergistic from the 240h. At LC50 and LC90 effect level, the mixture interaction resulted synergistic for all exposure times. This is the first study to report the synergistic interactions between GBH and 2,4-DBH on amphibians, alerting about its negative impact on aquatic ecosystems.

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