Exposure assessment of neonicotinoid insecticides and their metabolites in Chinese women during pregnancy: A longitudinal study

Mahai, Gaga; Wan, Yanjian; Xia, Wei; Wang, Aizhen; Qian, Xi; Liu, Ying; He, Zhen-Yu; Li, Yuanyuan; Xu, Shunqing

doi:10.1016/j.scitotenv.2021.151806

Cited by 34 publications

(11 citation statements)

References 81 publications

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“…Compared to other similar studies, Wang et al found that the urinary IMI RPF (including 5 neonicotinoids and 3 metabolites) in healthy adults ranged from 0.92 to 167 μg/L (SG-adjusted), with a medium concentration of 11.10 μg/L in Wuhan, China . Mahai et al measured urine samples donated by China’s pregnant women and found that the IMI RPF (4 neonicotinoids and 5 metabolites) varied from 0.20 to 1817 μg/L (SG-adjusted), with a median of 14.10 μg/L . Herein, the median was detected within 6.25–10.75 μg/L during 6 weeks, which was relatively comparable to the findings of the above research.…”

Section: Resultsmentioning

confidence: 99%

“…28 Mahai et al measured urine samples donated by China's pregnant women and found that the IMI RPF (4 neonicotinoids and 5 metabolites) varied from 0.20 to 1817 μg/L (SG-adjusted), with a median of 14.10 μg/L. 29 Herein, the median was detected within 6.25−10.75 μg/L during 6 weeks, which was relatively comparable to the findings of the above research. Considering that the detected concentrations of the metabolites in these biomonitoring-based studies were all an order of magnitude higher than the parent compound, the relatively low maximum value of the total neonicotinoids in this experiment may stem from the fact that we did not include the detection of metabolites.…”

Section: Individual and Total Neonicotinoids In Urinementioning

confidence: 99%

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MtDNA Copy Number in Oral Epithelial Cells Serves as a Potential Biomarker of Mitochondrial Damage by Neonicotinoid Exposure: A Cross-Sectional Study

Gu,

Fu,

Wang

et al. 2023

Environ. Sci. Technol.

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As the mitochondrial DNA copy number (mtDNAcn) has been reported to be a biomarker for mtDNA damage in honeybees when exposed to sublethal neonicotinoids, the feasibility of using human mitochondria as a predictor upon neonicotinoid exposure remains elusive. This study investigated the association between the urinary neonicotinoid and the relative mtDNAcn (RmtDNAcn) of oral epithelial cells collected in a cross-sectional study with repeated measurements over 6 weeks. The molecular mechanism underlying neonicotinoid-caused mitochondrial damage was also examined by in vitro assay. Herein, the average integrated urinary neonicotinoid (IMIRPF) concentration ranged from 8.01 to 13.70 μg/L (specific gravity-adjusted) during the sampling period. Concomitantly, with an increase in the urinary IMIRPF, the RmtDNAcn significantly increased from 1.20 (low group) to 1.93 (high group), indicating potential dose-dependent mitochondrial damage. Furthermore, the linear regression analysis confirmed the significant correlation between the IMIRPF and RmtDNAcn. Results from in vitro assays demonstrated that neonicotinoid exposure led to the inhibition of the genes encoding mitochondrial oxidative phosphorylation (OXPHOS) complexes I and III (e.g., ND2, ND6, CytB, and CYC1), accompanied by increased reactive oxygen species production in SH-SY5Y cells. Conjointly, neonicotinoid exposure led to mitochondrial dysfunction and a resulting increase in the RmtDNAcn, which may serve as a plausible biomarker in humans.

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Section: Resultsmentioning

confidence: 99%

Section: Individual and Total Neonicotinoids In Urinementioning

confidence: 99%

MtDNA Copy Number in Oral Epithelial Cells Serves as a Potential Biomarker of Mitochondrial Damage by Neonicotinoid Exposure: A Cross-Sectional Study

Gu,

Fu,

Wang

et al. 2023

Environ. Sci. Technol.

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“…Some studies have reported urinary concentrations of p-NEOs and m-NEOs in pregnant women. ,, The concentrations of most NEOs determined in these studies were somewhat higher than those measured in MS samples in this work, although this was not true for IMI. Previous studies have proven that renal elimination is the major route for the excretion of NEOs in humans, , with 19–55% of NEOs being excreted within 24 h. , Therefore, urinary concentrations of NEOs are often higher than those measured in serum.…”

Section: Resultsmentioning

confidence: 99%

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

Zhang

Bai

Zhang

et al. 2022

Environ. Sci. Technol.

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Studies on neonicotinoid (NEO) exposure in pregnant women and fetuses are scarce, and transplacental transfer of these insecticides is unknown. In this study, parent NEOs (p-NEOs) and their metabolites (m-NEOs) were determined in 95 paired maternal (MS) and cord serum (CS) samples collected in southern China. Imidacloprid was the predominant p-NEO in both CS and MS samples, found at median concentrations of 1.84 and 0.79 ng/mL, respectively, whereas N-desmethylacetamiprid was the most abundant m-NEO in CS (median: 0.083 ng/mL) and MS (0.13 ng/mL). The median transplacental transfer efficiencies (TTEs) of p-NEOs and m-NEOs were high, ranging from 0.81 (thiamethoxam, THM) to 1.61 (olefinimidacloprid, of-IMI), indicating efficient placental transfer of these insecticides. Moreover, transplacental transport of NEOs appears to be passive and structuredependent: cyanoamidine NEOs such as acetamiprid and thiacloprid had higher TTE values than the nitroguanidine NEOs, namely, clothianidin and THM. Multilinear regression analysis revealed that the concentrations of several NEOs in MS were associated significantly with hematological parameters related to hepatotoxicity and renal toxicity. To our knowledge, this is the first analysis of the occurrence and distribution of NEOs in paired maternal−fetal serum samples.

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“…( 2022 ) and Mahai et al. ( 2022 ) were scored as Tier 3, whereas the study of Oya et al. ( 2021 ) as Tier 2.…”

Section: Human Healthmentioning

confidence: 99%

“…The results of the Mahai et al. ( 2022 ) and Oya et al. ( 2021 ) studies could be extrapolated to their respective contexts (geographical areas, customs, diet, ethnic peculiarities, etc.).…”

Section: Human Healthmentioning

confidence: 99%

Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

Hernandez‐Jerez,

Coja,

Paparella

et al. 2024

EFS2

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Acetamiprid is a pesticide active substance with insecticidal action whose approval was renewed by Commission Implementing Regulation (EU) 2018/113. In January 2022, the EFSA PPR Panel published a statement following a request from the European Commission to advise on human health or the environment based on new scientific evidence presented by France during the decision‐making phase. In July 2022, by means of a further mandate received from the European Commission, EFSA was requested to provide advice if new information and any other scientific evidence that has become available since the assessment conducted for the renewal in 2018 warrant re‐evaluation of (i) toxicological parameters used for the risk assessment of acetamiprid during the renewal process, including toxicological endpoints; (ii) the residue definition for acetamiprid in products of plant origin; and (iii) the safety of existing maximum residue levels (MRLs). Meanwhile, the applicant of acetamiprid in the EU submitted new toxicology studies regarding the toxicological profile of the metabolite IM‐2‐1. Furthermore, the European Commission was made aware that several recent publications in scientific literature were made available after the literature searches conducted by EFSA. As the new data could affect the advice that EFSA was expected to deliver through the 2022 mandate, EFSA was further requested to consider this information by means of a revised mandate received in September 2023. As regards re‐evaluation of point (i) in this statement, this was addressed by an EFSA Working Group integrating all the available evidence. The results of the weight of evidence indicated that there are major uncertainties in the body of evidence for the developmental neurotoxicity (DNT) properties of acetamiprid and further data are therefore needed to come to a more robust mechanistic understanding to enable appropriate hazard and risk assessment. In view of these uncertainties, the EFSA WG proposed to lower the acceptable daily intake (ADI) and acute reference dose (ARfD) from 0.025 to 0.005 mg/kg body weight (per day). A revised residue definition for risk assessment was proposed for leafy and fruit crops as sum of acetamiprid and N‐desmethyl‐acetamiprid (IM‐2‐1), expressed as acetamiprid. Regarding pulses/oilseeds, root crops and cereals, the new data received did not indicate a need to modify the existing residue definition for risk assessment, which therefore remains as parent acetamiprid. Regarding the residue definition for enforcement, the available data did not indicate a need to modify the existing definition because acetamiprid is still a sufficient marker of the residues in all crop groups. Considering the new health‐based guidance values derived in the present statement, a risk for consumer has been identified for 38 MRLs currently in place in the EU Regulation. Consequently, EFSA recommended to lower the existing MRLs for 38 commodities based on the assessment of fall‐back Good Agricultural Practices received within an ad...

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Exposure assessment of neonicotinoid insecticides and their metabolites in Chinese women during pregnancy: A longitudinal study

Cited by 34 publications

References 81 publications

MtDNA Copy Number in Oral Epithelial Cells Serves as a Potential Biomarker of Mitochondrial Damage by Neonicotinoid Exposure: A Cross-Sectional Study

MtDNA Copy Number in Oral Epithelial Cells Serves as a Potential Biomarker of Mitochondrial Damage by Neonicotinoid Exposure: A Cross-Sectional Study

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

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