Exposure assessment and initial intervention regarding fish consumption of tribal members of the Upper Great Lakes Region in the United States

Dellinger, John A.

doi:10.1016/j.envres.2003.07.012

Cited by 60 publications

(35 citation statements)

References 18 publications

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“…These relatively low current body burdens are most likely the result of the significant declines in reported fish consumption over time among the Mohawk men (Fitzgerald et al, 1999). The Mohawk values are also similar to the range of 1.4-3.1 ppb for average serum total PCB concentrations reported by Dellinger (2004) for 822 tribal members from several Obijwe and Menominee reservations in Michigan, Minnesota, and Wisconsin from 1993 to 2000. This resemblance in PCB body burden between the Mohawk and the Obijwe and Menominee peoples reflects similarity in their rates of local fish consumption, which currently averaged 21.2 meals per year for the Mohawk men and ranged from 12 to 34 meals per year for the Obijwe and Menominee.…”

Section: Discussionsupporting

confidence: 62%

Environmental and occupational exposures and serum PCB concentrations and patterns among Mohawk men at Akwesasne

Fitzgerald

Hwang

Gómez

et al. 2006

J Expo Sci Environ Epidemiol

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A study was conducted to address the question of how fish consumption, occupation, and outdoor air affected serum PCB concentrations and congener patterns among 139 Native American men living near three hazardous waste sites. They were interviewed about their residential, occupational, and dietary histories, and donated 20 ml of venous blood for congener-specific PCB analysis. The similarity in the congener pattern between that found in the serum and that detected in local environmental samples was measured by calculating the Euclidean distance between them. The results indicated that serum PCB concentrations were positively associated with cumulative lifetime exposures to PCBs from local fish consumption and occupation. However, participants who lived in the last 10 years at Raquette Point, which is the area of the Reserve closest to the hazardous waste sites and the only location where elevated levels of PCBs were found in outdoor air, did not have higher serum PCB concentrations than participants who lived elsewhere at Akwesasne. Regarding pattern matching, Mohawk men with the greatest cumulative lifetime exposure to PCBs from local fish consumption had a serum PCB congener pattern that more closely resembled that in fish caught off-shore from one of the hazardous waste sites than did men who ate less local fish. Similarly, Mohawk men who were occupationally exposed to PCBs were more likely than those without occupational exposure to have a serum PCB congener pattern that was similar to that of Aroclor 1248, the commercial PCB mixture used locally. The serum PCB congener pattern of Raquette Point residents more closely resembled the pattern in outdoor air only if the men ate relatively few local fish. The study is among the first to demonstrate that outdoor air may affect serum PCB congener patterns, at least in the absence of heavy fish consumption.

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Section: Discussionsupporting

confidence: 62%

Environmental and occupational exposures and serum PCB concentrations and patterns among Mohawk men at Akwesasne

Fitzgerald

Hwang

Gómez

et al. 2006

J Expo Sci Environ Epidemiol

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“…Humans and other animals are continuously exposed to low levels of PCBs from soil, air and food sources [7,8]. In populations in which there are large amounts of fish consumption, PCBs can bioaccumulate and noticeably alter physical and motor development [9,10]. Studies on natural animal populations consistently find moderate-to-high levels of PCBs in many diverse animal groups [range in concentration from 3 to 500 ng/g; [11][12][13]] and it is principally unknown as to how this exposure influences development of psychological function.…”

Section: Introductionmentioning

confidence: 99%

Effects of polychlorinated biphenyls on maternal odor conditioning in rat pups

Cromwell

Johnson

McKnight

et al. 2007

Physiology & Behavior

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Polychlorinated biphenyls (PCBs) are pervasive environmental contaminants that can have damaging effects on physiologic, motoric and cognitive function. Results from studies on PCBs and behavior have shown that exposure can alter learning and memory processes and that these shifts in cognitive abilities can be related to changes in hormonal and neural function. Little experimentation has been done on the impact of exposure to PCBs on social and emotional development. Previous work has shown that exposure to PCBs in children can alter play behavior. Importantly, exposure to PCBs has been found to change aspects of maternal-offspring interactions in rodents. The present study examined the impact of PCBs on maternal odor conditioning in rat pups 12-14 days of age. A modified version of the conditioned place preference paradigm was used that incorporated a maternal-associated odor cue (lemon scent) as the conditioned stimulus. PCBs significantly depressed the preference for the maternal-associated cue but did not impair discrimination for a novel odor. These effects could arise due to changes in the social dynamics between the dam and offspring after co-exposure to PCBs. For example, dams exposed to PCBs during gestation have been found to show elevated grooming directed towards pups exposed to PCBs. This change in maternal care can have dramatic effects on behavioral and hormonal systems in the developing rat pup. In conclusion, perinatal PCBs alter important social behaviors of both the mother and pup, and these alterations could have long-lasting effects on behavioral, cognitive and emotional development.

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“…Many researchers have observed elevated mercury concentrations in different species of fish (Brazner and DeVita, 1998;Dellinger, 2004;Fox et al, 2002;Gerstenberger and Dellinger, 2002;Koster et al, 1996;Scheider et al, 1998;Weis, 2004) including invasive fish species (MacEachen et al, 2000) in the Great Lakes. In addition, there are numerous reports of mercury contamination in the waters (Mason and Sullivan, 1997;Rolfhus et al, 2003;Thompson-Roberts et al, 1999), sediments (Marvin et al, 2002;Marvin et al, 2003;Marvin et al, 2004;Painter et al, 2001;Richman and Dreier, 2001;Rolfhus et al, 2003;Rossmann, 2002;Rossmann and Edgington, 2000) and biota other than fish (Bishop et al, 1995;Cleckner et al, 2003;Francis et al, 1998) of the Great Lakes-St. Lawrence River basin.…”

Section: Mercury In the Great Lakesmentioning

confidence: 96%