Exposure Assessment: Analysis of Human Intake of Chemicals

Asante-Duah, Kofi

doi:10.1007/978-94-024-1039-6_9

Cited by 3 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirdly, it allows for the development and measurement of biomarkers for disease at any stages. There is a long way to go from exposure to observed effects: external dose; internal dose; target organ dose; target organ metabolism; target organ responses; cellular/subcellular dose and interaction; toxic response; observed effects [90]. The biomarker development of diseases can help explain the roles of environmental exposures in the pathogenesis of diseases as well as facilitate the diagnostic and prognostic of diseases.…”

Section: Measurement-based Exposome Studiesmentioning

confidence: 99%

Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions

Xue

Lai

et al. 2019

Toxics

View full text Add to dashboard Cite

The proposal of the “exposome” concept represents a shift of the research paradigm in studying exposure-disease relationships from an isolated and partial way to a systematic and agnostic approach. Nevertheless, exposome implementation is facing a variety of challenges including measurement techniques and data analysis. Here we focus on the chemical exposome, which refers to the mixtures of chemical pollutants people are exposed to from embryo onwards. We review the current chemical exposome measurement approaches with a focus on those based on the mass spectrometry. We further explore the strategies in implementing the concept of chemical exposome and discuss the available chemical exposome studies. Early progresses in the chemical exposome research are outlined, and major challenges are highlighted. In conclusion, efforts towards chemical exposome have only uncovered the tip of the iceberg, and further advancement in measurement techniques, computational tools, high-throughput data analysis, and standardization may allow more exciting discoveries concerning the role of exposome in human health and disease.

show abstract

Section: Measurement-based Exposome Studiesmentioning

confidence: 99%

Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions

Xue

Lai

et al. 2019

Toxics

View full text Add to dashboard Cite

show abstract

Heavy metal contamination levels, source distribution, and risk assessment in fine sand of urban surface deposited sediments of Ekaterinburg, Russia

Hanfi

Seleznev

Yarmoshenko

et al. 2023

Environ Geochem Health

View full text Add to dashboard Cite

Comparison Process of Blood Heavy Metals Absorption Linked to Measured Air Quality Data in Areas with High and Low Environmental Impact

et al. 2022

View full text Add to dashboard Cite

Air pollution is a problem shared by the entire world population, and researchers have highlighted its adverse effects on human health in recent years. The object of this paper was the relationship between the pollutants’ concentrations measured in the air and the quantity of pollutant itself inhaled by the human body. The area chosen for the study has a high environmental impact given the significant presence on the territory of polluting activities. The Acerra area (HI) has a waste-to-energy plant and numerous industries to which polluting emissions are attributed. This area has always been the subject of study as the numbers of cancer patients are high. A survey on male patients to evaluate the heavy metals concentrations in the blood was conducted in the two areas and then linked to its values aero-dispersed. Using the air quality data measured by the monitoring networks in two zones, one with high environmental impact (HI) and one with low environmental impact (LI), the chronicle daily intake (CDI) of pollutants inhaled by a single person was calculated. The pollutants considered in this study are PM10 and four heavy metals (As, Cd, Ni, Pb) constituting the typical particulates of the areas concerned. The CDI values calculated for the two zones are significantly higher in the HI zone following the seasonal pollution trend.

show abstract

Exposure Assessment: Analysis of Human Intake of Chemicals

Cited by 3 publications

References 19 publications

Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions

Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions

Heavy metal contamination levels, source distribution, and risk assessment in fine sand of urban surface deposited sediments of Ekaterinburg, Russia

Comparison Process of Blood Heavy Metals Absorption Linked to Measured Air Quality Data in Areas with High and Low Environmental Impact

Contact Info

Product

Resources

About