Exposure and sensitization to cat dander: Asthma and asthma-like symptoms among adults

Noertjojo, Kukuh; Dimich‐Ward, Helen; Obata, Hideto; Manfreda, Jure; Chan‐Yeung, Moira

doi:10.1016/s0091-6749(99)70526-9

Cited by 36 publications

(17 citation statements)

References 26 publications

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“…The authors conclude that exposure to Fel d 1 levels w8 mg?g dust -1 is a risk factor for asthma attacks and respiratory symptoms in sensitized subjects. These findings are in line with the findings of NOERTJOJO et al [33], who found cat owners to have a significantly higher risk of having current asthma and asthma-like symptoms compared to persons without cats. In the subset with positive skin-prick tests, they found that those who were allergic to cat dander had a significantly higher risk of current asthma than those not allergic to cat dander and not keeping a cat.…”

Section: Cat Allergens and Respiratory Healthsupporting

confidence: 92%

Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins

Gehring

Heinrich²,

Jacob³

et al. 2001

Eur Respir J

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The authors investigated the relationship between respiratory symptoms in adults and exposure to mite and cat allergens, the role of endotoxins in house dust, the effects of mixtures of several allergens, and interactions between allergen exposure and allergic sensitization.Within a nested case-control study, 405 subjects aged 25–50 yrs from two German cities answered a standardized questionnaire. Allergen-specific immunoglobulin-E was measured. Dust samples were taken from the subjects' homes to determine exposure to mite (Dermatophagoides pteronyssinusantigen 1Der p1) and (D. farinaeantigen 1Der f1) and cat (cat antigen d1Fel d1) allergen and endotoxin content in settled house dust.Exposure toDer f1 andDer p1 plusDer f1 >10 µg·g−1of mattress dust, respectively, increased the risk of wheeze and breathlessness (odds ratios (OR): 4.04, 95% confidence interval (CI): 1.53–10.64, OR: 2.78, 95% CI: 1.06–7.28).Fel d1 >8 µg·g−1was positively associated with cough at night (OR: 2.74, 95% CI: 1.22–6.17), noteworthy also in the nonsensitized subjects. Subjects exposed to elevated concentrations of more than one allergen had an up to seven-fold increase in the risk of respiratory symptoms, compared to nonexposed subjects. Sensitized subjects exposed to elevated concentrations ofDer f1 orFel d1 were found to have the highest risk of asthma attacks and respiratory symptoms. No statistically significant association was found between exposure to endotoxins and respiratory health.Indoor exposure toDermatophagoides farinaeantigen 1 and cat antigen d1 is a risk factor for respiratory symptoms in adults, and for cat antigen d 1 even in nonsensitized subjects. The risk is increased if subjects are exposed to a mixture of allergens or if they are sensitized in addition to high exposure.

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Section: Cat Allergens and Respiratory Healthsupporting

confidence: 92%

Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins

Gehring

Heinrich²,

Jacob³

et al. 2001

Eur Respir J

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“…Several cross-sectional studies are listed in Table 4 [4,[27][28][29][30][31][32][33][34][35], with results on large numbers of young adults from Europe, Canada, Australia, and Estonia. Most sensitization occurs before adulthood and, therefore, all of these studies rely on recall for pet ownership and contact information.…”

Section: Adult Studiesmentioning

confidence: 99%

“…For sensitization to cat, the results were mixed, with only one study reporting no association [32]. A study in the United Kingdom, in which the population was divided into deciles of exposure to mattress Fel d 1, found lowest sensitization rates at the highest and lowest deciles of exposure [33].…”

Section: Adult Studiesmentioning

confidence: 99%

Pets and the development of allergic sensitization

Simpson

Čustović

2005

Curr Allergy Asthma Rep

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Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. Several reports have indicated that living with a pet reduces the risk for becoming sensitized to that pet. Having a pet in the home gives exposure to more than just allergens. In areas with high frequency of pet ownership, community exposure to pet allergens is almost certainly sufficient to induce sensitization among non-pet owners. In this review, we examine the results of recent studies that have investigated the relationship between pet ownership, specific sensitization to that pet, and allergic sensitization in general. For cat ownership, the results are inconsistent between studies of similar design, with some studies suggesting an increase in risk and others a decrease among cat owners. For dogs, results are more consistent, generally suggesting that owning a dog has no effect or indeed may be protective against the development of specific sensitization to dog and allergic sensitization in general.

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“…13,14 Sensitization to domestic pets, particularly cats, is also more often present in asthma. [9][10][11][14][15][16][17] This observation might serve as a pointer toward prevention strategies for at least 1 of the triggers that induces asthma exacerbations. However, the situation with domestic pets is complex.…”

mentioning

confidence: 99%

Presence and timing of cat ownership by age 18 and the effect on atopy and asthma at age 28

Meer

Toelle

et al. 2004

Journal of Allergy and Clinical Immunology

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Exposure and sensitization to cat dander: Asthma and asthma-like symptoms among adults

Cited by 36 publications

References 26 publications

Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins

Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins

Pets and the development of allergic sensitization

Presence and timing of cat ownership by age 18 and the effect on atopy and asthma at age 28

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