In this paper, the problem of adaptive synchronization is investigated for a class of CohenCrossberg neural networks with mixed time delays. Based on a Lyapunov-Krasovskii functional and the invariant principle of function differential equations as well as the adaptive control and linear feedback with update law, a linear matrix inequality approach is developed to derive some novel sufficient conditions achieving synchronization of the two coupled networks with mixed time delays. In particular, the mixed time delays in this paper synchronously consist of constant delays, time-varying delays, and distributed delays, which are more general than those discussed in the previous literature. Therefore, the results obtained in this paper comprise and generalize those given in the previous literature. A numerical example and its simulation are provided to show the effectiveness of the theoretical results.