Exploring versatile applications of cyclodextrins: an overview

Abstract

Context: Ever since the discovery of cyclodextrins, a family of cyclic oligosaccharides based on a (1 ! 4) linkage among glucopyranose subunits, these versatile supramolecular hosts have received tremendous attention for scientific explorations. Due to their property of forming host-guest type inclusion complex, cyclodextrins and their synthetic derivatives exhibit wide range of utilities in different areas viz. pharmaceuticals, drug delivery systems, cosmetics, food and nutrition, textile and chemical industry etc. Objective: The purpose of this review is to highlight properties, advantages, recent studies and versatile benefits of cyclodextrins and to re-strengthen their prospective applications in novel directions for future research. Methods: This article summarizes a variety of applications of cyclodextrins in various industrial products, technologies, analytical and chemical processes and recent industrial advancements by extensively literature search on various scientific databases, Google and websites of various associated pharmaceutical industries and patenting authorities across the world. Results and conclusion: Due to possibility of multidimensional changes in physical and chemical properties of molecules upon inclusion complexation in cyclodextrins, these compounds are of great commercial interest and may offer solution to many of the scientific problems of the current world.

Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches

“…Due to their properties of forming host-guest type inclusion complexes, CDs and their synthetic derivatives exhibit a wide range of utilities in different areas, such as in pharmaceuticals, in drug delivery systems, in cosmetics, in food and nutrition, in textiles, and in the chemical industry (Loftsson, 2002;Marques, 2010a;Roux, Perly & Djedaini-Pilard, 2007). This capability has led to extensive investigations into cyclodextrin applications in several different areas, with the purpose of overcoming certain limitations (Brito, Araujo, Quintans, Sluka & QuintansJunior, 2015;Oliveira, Guimaraes, Araujo, Quintans, Santos & Quintans-Junior, 2015;Sharma & Baldi, 2016;Varca, Andreo-Filho, Lopes & Ferraz, 2010).…”

Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update

“…Cyclodextrins can be used for the solubilization of poorly water-soluble drugs due to the inclusion effect by Vander Waals interaction, hydrogen bonding and charge transfer interactions (4,85,86). However, cyclodextrins are also known to form non-inclusion complexes (87,88).…”

Structure, electronic, inclusion complex formation behavior and spectral properties of pillarplex

“…The nature and use of the macrocycles are decided by their shape, synthesis, solubility in organic solvents and aqueous media, their functionalization and their host-guest binding ability [4]. Among the macrocyclic molecules, the selective molecular recognition and self-assembly properties of several classical supramolecular macrocycles, including that of, crown ethers [5], cyclophanes [6], cyclodextrins (CDs) [7,8], cucurbit[n] urils (CB[n]) [9,10], calix[n]arenes [11,12], and Pillar[n] arenes [13] were well documented. Furthermore, most of these macrocycles are neutral molecules and are capable of binding charged guest molecules.…”