Exploring various measures of the area under the curve for the assessment of dose-proportionality and estimation of bioavailability
Dion R Brocks,
Elisabeth A Minthorn,
Brian E Davies
Abstract:Objective
In pharmacokinetics, the area under the concentration versus time curve (AUC) extrapolated to infinity (AUC0−∞) is the preferred metric but it is not always possible to have a reliable estimate of the terminal phase half-life. Here we sought to explore the accuracy of three different area measures to accurately identify dose proportionality and bioavailability.
Methods
One to three compartment model simulations with… Show more
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