Exploring the Villalta scale to capture postthrombotic syndrome using alternative approaches: A subanalysis of the ATTRACT trial

Pop, Cristina; Gu, Chu‐Shu; Vedantham, Suresh; Galanaud, Jean‐Philippe; Kahn, Susan R.

doi:10.1016/j.rpth.2022.100032

Cited by 2 publications

(5 citation statements)

References 26 publications

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“…The broad confidence interval reflects the significant variability in the observed frequency. We found that adults had a lower incidence of PTS diagnosis (15.4%) compared to children (66.7%) 26,34 …”

Section: Discussionmentioning

confidence: 63%

“…Overall PTS score in the adult survivors was higher compared to the pediatric survivors (1 point/child, 1.6 points/adult). A VS ≥5 has been validated to distinguish clinical meaningful PTS in adults, 34,41 which explains why fewer adult survivors received a PTS diagnosis. Six pediatric survivors had collaterals (50%) (1 point), only three of these survivors had another symptom and ended up with two or three points.…”

Section: Discussionmentioning

confidence: 99%

“…We found that adults had a lower incidence of PTS diagnosis (15.4%) compared to children (66.7%). 26,34 PTS has been characterized as a condition with significant challenges. 23,39,40 Interestingly, the pediatric survivors in this study who had a PTS diagnosis did not seem to carry a noticeable burden.…”

Section: Discussionmentioning

confidence: 99%

“…PTS can be diagnosed according to various scoring tools 23,24 . In this study, adults (≥18 years) were evaluated by means of Villalta Scale (VS) 34 . Ratings ranged from none (0 points) to severe (3 points), while mild and moderate were assigned 1 and 2 points, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…23,24 In this study, adults (≥18 years) were evaluated by means of Villalta Scale (VS). 34 Ratings ranged from none (0 points) to severe (3 points), while mild and moderate were assigned 1 and 2 points, respectively. A VS of 5-9 was denoted mild, 10−14 moderate, and ≥15 severe PTS (Table 1).…”

Section: Post-thrombotic Syndromementioning

confidence: 99%

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Sequelae and post‐thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol

Dam,

Lynggaard,

Jónsson

et al. 2024

Pediatric Blood & Cancer

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The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post‐thrombotic syndrome (PTS), a group of signs and symptoms developed as a complication to deep venous thrombosis (DVT), imposing risk of permanent disability and reduced quality of life (QoL). PTS prevalence ranges from 0% to 70%, reflecting very heterogenous cohorts and assessment tools. We aimed to estimate sequelae, including PTS and QoL in children and adults (<45 years old) who had a DVT during ALL treatment. PTS and QoL scores were obtained through use of Villalta and Modified Villalta Scale, PedsQL, and Short Form‐36 questionnaires. The cohort comprised 20 children (<18 years) and seven adults (median age: 12.9 years, range: 2–44 years) at the time of DVT diagnosis. In total, 25 ALL survivors underwent PTS examination. The examination took place when survivors were 7–48 years (median age: 20.3 years, median follow‐up time 6.8 years). QoL was assessed correlating cases with three matching ALL survivors without VTE. Two adults (15.4%) showed mild or moderate PTS. Eight children (66.7%) were diagnosed with mild PTS, while three cases had collaterals as sole symptoms. Pain or symptoms affecting daily life were reported by 16%. No difference in QoL was found (p = .9). This study underscores the need for comprehensive population‐based investigations with validation of PTS instruments in ALL survivors.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Post-thrombotic Syndromementioning

confidence: 99%

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Sequelae and post‐thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol

Dam,

Lynggaard,

Jónsson

et al. 2024

Pediatric Blood & Cancer

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Diagnosis of post-thrombotic syndrome: International union of phlebology (UIP) survey of medical specialists

Xu,

Siriwardene,

Naidu

et al. 2024

Phlebology

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Objective To review the current approaches to the diagnosis of Post-Thrombotic Syndrome (PTS) and to evaluate the potential need for a diagnostic tool. Method Medical specialists were invited to participate in an online survey of their current approaches to the diagnosis and management of PTS, including the use of scoring systems, diagnostic imaging techniques and the extent the practitioner reviews the patient’s venous history. Results 502 participants completed the survey. Over 80% obtained imaging reports to confirm a history of deep vein thrombosis (DVT). 72% of participants always obtained an up-to-date duplex ultrasound for PTS diagnosis. Over 50% did not use a scoring system for either PTS diagnosis or management. 65% of the participants agreed that a new system for PTS diagnosis should be devised. Conclusion Heterogeneity was observed in methods of diagnosing PTS by medical practitioners with frequent use of medical imaging studies and moderate use of scoring systems. Development of a new diagnostic tool for PTS should be considered for future studies.

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Exploring the Villalta scale to capture postthrombotic syndrome using alternative approaches: A subanalysis of the ATTRACT trial

Cited by 2 publications

References 26 publications

Sequelae and post‐thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol

Sequelae and post‐thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol

Diagnosis of post-thrombotic syndrome: International union of phlebology (UIP) survey of medical specialists

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