Exploring the value and acceptability of peer support in the process of improving adherence to HIV antiretroviral drugs in Tanzania, Dar-es-Salaam

Dehens, Joram; Hemptinne, Maud de; Galouchka, Michaël; Sajud, Abdus; Otzel, Reinier Petrus van; Vanhoorebeeck, Cedric; Wyszkowska, Małgorzata; Mosha, Fausta; Sangeda, Raphael Zozimus; Bernard, Edwin J; Thompson, Marc; Kiekens, Anneleen; Baert, Saar; Blanco, Jorge Ricardo Nova; Jordan, Michael R.; Vandamme, Anne-Mieke

doi:10.11116/tdi2017.1.2

Cited by 5 publications

(8 citation statements)

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“…After a comprehensive literature review, a semi-structured questionnaire was prepared. The questionnaire contained open and close-ended questions 18 – 20 . The English questionnaire was constructed, translated to Kiswahili (local language).…”

Section: Methodsmentioning

confidence: 99%

Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania

Kilapilo

Sangeda

Bwire

et al. 2022

J Int Assoc Provid AIDS Care

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Background: Adherence to antiretroviral therapy (ART) is the key determinant of virological suppression in people living with HIV (PLHIV). This study reports factors associated with non-adherence among PLHIV one year after introducing dolutegravir (DTG) based regimens in Tanzania. Methods: A hospital-based cross-sectional study was conducted in two health facilities in Dar es Salaam, Tanzania, in 2020. Results: A total of 406 PLHIV were recruited, where the majority (73.4%) were females, with 94.6% of patients being on DTG based regimens. Factors such as refill interval and sharing of antiretrovirals had significant effects on adherence. Multivariate analysis found that patients attending care and treatment center (CTC) at Temeke Regional Referral Hospital (RRH) were 4.3 times more likely to have non-adherence compared to those attending Amana RRH (aOR [adjusted odds ratio] 4.3, 95% CI [confidence interval]: 2.38 – 7.91, p-value < 0.0001). Conclusions: Sustainable adherence counseling is warranted to overcome non-adherence to ART.

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Section: Methodsmentioning

confidence: 99%

Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania

Kilapilo

Sangeda

Bwire

et al. 2022

J Int Assoc Provid AIDS Care

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“…During the first 3 months of the project, the team was trained in transdisciplinarity and complexity through various workshops and exercises [15]. Over the course of eleven sessions, the students developed a shared understanding of the HIVDR challenge, identified the latest state of the problem and worked towards parsing its complexity.…”

Section: Methodsmentioning

confidence: 99%

“…"A way to understand and prevent HIV drug resistance in Africa." Supplement 1: Revised Challenge document In 2016, the "original" challenge was researched by a team of students of this same honours programme, and their insights were published (Dehens et al, 2017). As a result of those efforts, the here listed "revised" challenge document was submitted in 2017.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…Thereby, the team built upon the work of the preceding year, during which another student research team had worked on a similar challenge in the context of the Honours Programme Transdisciplinary Insights at KU Leuven. This team had explored the value and acceptability of peer support groups in Dar-es-Salaam, Tanzania, in order to improve HIV treatment adherence [15]. The research undertaken by the student team and presented herein therefore had three main objectives.…”

Section: Hiv-positive Men As a Key Population For Fighting Hivdr In Africa Introductionmentioning

confidence: 99%

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HIV-positive men as a key population for fighting HIVDR in Africa

Herrmann

Lushaba

Michielsen

et al. 2018

Transdisciplinary Insights

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This article is concerned with transdisciplinarity as a framework for addressing the wicked problem of rising HIV drug resistance (HIVDR) rates in Africa and its implications. According to data published by the Joint United Nations Programme on HIV/AIDS (UNAIDS), even though the number of AIDS-related deaths has declined by 48% between 2005 and 2016, this significant decrease is now threatened by a rise in resistance of HIV to antiretroviral drugs in several regions, including Africa. Through the application of transdisciplinary research methods, the team identified various factors with an impact on HIVDR, of which they found adherence to be the one most reasonable to address in the context of their research project. Subsequently, the team sought to characterise factors influencing non-adherence among HIV+ individuals. By identifying the current state of the problem, existing gaps in knowledge needed to tackle the issue and stakeholders with a pronounced impact on HIV+ individuals’ adherence and beliefs, non-governmental organisations and community health workers were established as particularly important actors. As a result of discussions with external experts and a review of the literature, the poor health-seeking behaviour of men, who represent a group particularly challenging to engage, became the focal point of the project. Eventually, investigating the possibility of setting up a health helpline providing <target target-type="page-num" id="p-79"/>peer-to-peer support to men living with HIV in South Africa was agreed upon as a concrete objective of the project in collaboration with Dr. Coenie Louw of the Gateway Health Institute. The attributes such a helpline would need to be useful and attractive to its target audience will be explored further in the near future by means of interviews with local community health workers as well as through focus group discussions with male HIV+ individuals in South Africa. A transdisciplinary approach to the problem of HIVDR facilitated the sharing of knowledge across multiple disciplines, which in turn facilitated the exchange of thoughts and ideas between students from different academic backgrounds and various stakeholders with expertise relevant to the project.

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“…A structured questionnaire with open and close-ended questions was prepared following an intensive literature review on a topic related to stigmatization, adherence and viral load suppression [9][10][11]. The English questionnaire was designed and translated to Kiswahili (local language).…”

Section: Data Collection Toolmentioning

confidence: 99%

Factors associated with viral load suppression and indicators of stigma among people living with HIV in Dar es Salaam tertiary hospitals, Tanzania

Kilapilo

Mosha

Bwire

et al. 2022

Preprint

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Perception of stigma can contribute to virological failure among people living with HIV (PLHIV). This study was conducted to assess the effect of stigmatization and self-discrimination on viral load suppression among PLHIV at tertiary hospitals in Dar es Salaam, Tanzania. This was a hospital-based cross-sectional study conducted in Temeke Regional Referral Hospital (RRH) and Amana RRH at the Care and Treatment Clinic (CTC) between July and August 2020 using a structured questionnaire with open and close-ended questions. Factors for stigmatization and viral load suppression were compared using the Chi-square test, while factors for viral load suppression were analyzed using multinomial logistic regression analysis. Altogether, 406 PLHIV participated, with most female respondents, 298 (73.2%). The majority (50%) were aged between 25 and 44 years, whereas 171 (42.5%) respondents were married. Most of the participants, 382 (94.6%), were on a dolutegravir-based regimen, with the majority, 215 (52.8%), having a refilling interval of three months. The majority of the respondents, 379 (93.1%), disclosed their status. Most participants, 355 (87.4%), preferred having a separate HIV clinic, while 130 (32.1%) participants were not ready to be attended by the health care workers (HCWs) familiar to them. Male patients were 60% less likely to suppress their viral load as compared to female patients (adjusted odds ratio [aOR]: 0.4, 95% confidence interval [95%]: 0.19 – 0.77, p = 0.007). Refill interval was significantly associated with viral load suppression. For example, patients with a one-month refill interval had odds of 0.01 (95% CI: 0.003-0.42, p < 0.0001) compared to six-month refill intervals. Stigmatization elements appeared to influence the viral load suppression among PLHIV. Factors such as gender and refill time interval were significantly associated with viral load suppression among HIV patients in the Dar es Salaam region.

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Exploring the value and acceptability of peer support in the process of improving adherence to HIV antiretroviral drugs in Tanzania, Dar-es-Salaam

Cited by 5 publications

References 0 publications

Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania

Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania

HIV-positive men as a key population for fighting HIVDR in Africa

Factors associated with viral load suppression and indicators of stigma among people living with HIV in Dar es Salaam tertiary hospitals, Tanzania

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