Exploring the Validity of the Continuum of Resistance Model for Discriminating Early from Late and Non-uptake of Colorectal Cancer Screening: Implications for the Design of Invitation and Reminder Letters

Gregory, Tess; Cole, Stephen R.; Wilson, Carlene; Flight, Ingrid; Zajac, Ian; Turnbull, Deborah; Young, Graeme P.

doi:10.1007/s12529-012-9254-1

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…15 , 16 Barriers to screening by both endoscopic and non-invasive fecal tests have been well described, and despite aggressive health promotion, participation rates remain suboptimal in organized screening programs. 17 , 18 , 19 , 20 For example, screening participation with FIT in the Australian National Bowel Cancer Screening Program is <35%. 21 The need for participants to provide fecal specimens is a behavioral barrier that has been well documented.…”

Section: Introductionmentioning

confidence: 99%

A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia

Symonds

Pedersen²,

Baker³

et al. 2016

Clinical and Translational Gastroenterology

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Objectives:To compare the performance of a new blood test for colorectal cancer (CRC) to an established fecal immunochemical test (FIT) in a study population with the full range of neoplastic and non-neoplastic pathologies encountered in the colon and rectum.Methods:Volunteers were asked to complete a FIT prior to colonoscopy. Blood was collected after bowel preparation but prior to colonoscopy, and plasma was assayed for the presence of methylated BCAT1 and IKZF1 DNA using a multiplex real-time PCR assay. Sensitivity and specificity estimates for the blood test were calculated from true- and false-positive rates for neoplasia and compared with FIT at a range of fecal hemoglobin (Hb) concentration positivity thresholds.Results:In total, 1,381 volunteers (median age 64 years; 49% male) completed both tests prior to colonoscopy. Estimated sensitivity of the BCAT1/IKZF1 blood test for CRC was 62% (41/66; 95% confidence interval 49–74%) with a specificity of 92% (1207/1315; 90–93%). FIT returned the same specificity at a cutoff of 60 μg Hb/g, at which its corresponding sensitivity for cancer was 64% (42/66; 51–75%). In the range of commonly used FIT cutoffs, respective cancer sensitivity and specificity estimates with FIT were: 59% (46–71%) and 93% (92–95%) at 80 μg Hb/g, and 79% (67–88%) and 81% (78–83%) at 10 μg Hb/g. Although estimated sensitivities were not significantly different between the two tests for any stage of cancer, FIT showed a significantly higher sensitivity for advanced adenoma at the lower cutoffs. Specificity of FIT, but not of the BCAT1/IKZF1 blood test, deteriorated substantially in people with overt blood in the feces. When combining FIT (cutoff 10 μg Hb/g) with the BCAT1/IKZF1 blood test, sensitivity for cancer was 89% (79–96%) at 74% (72–77%) specificity.Conclusions:A test based on detection of methylated BCAT1/IKZF1 DNA in blood has comparable sensitivity but better specificity for CRC than FIT at the commonly used positivity threshold of 10 μg Hb/g. Further evaluation of the new test relative to FIT in the population screening context is now required to fully understand the potential advantages and disadvantages of these biomarkers in screening.

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Section: Introductionmentioning

confidence: 99%

A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia

Symonds

Pedersen²,

Baker³

et al. 2016

Clinical and Translational Gastroenterology

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“…To handle potential non-response bias, we will conduct a wave analysis (Lin & Schaeffer, 1995;Lahaut et al, 2003). Late responders have a tendency to be similar to nonparticipants in what is known as the 'continuum of resistance' model (Lin & Schaeffer, 1995;Gregory et al, 2013). Differences in the distribution of defined socio-demographic variables between response waves, that is, early versus late responders, will be analysed to elucidate whether early responders differ from late responders.…”

Section: Statistical Analysesmentioning

confidence: 99%

The Food Addiction Denmark (FADK) Project: a combined survey and register-based study

Horsager

Østergaard

Lauritsen

2019

Acta Neuropsychiatr.

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Background:Obesity represents a tremendous global health problem. Studies over the past decade have suggested that food addiction (FA), that is, physical cravings for certain foods – high in fat/sugar – and addiction-like overeating of these types of food, is a likely contributor to the obesity epidemic. While FA has been studied extensively, there are some significant gaps in the literature that need to be addressed: (I) Most estimates of the prevalence of FA are based on nonprobability sampling, which significantly limits the representativeness of the prevalence estimates. (II) Although addiction disorders are prevalent among individuals with mental disorders, large studies of FA among patients with clinically diagnosed mental disorders are lacking. (III) Most addiction disorders are heritable, but the familial transmission of FA remains virtually unknown. (IV) Due to a relative lack of longitudinal studies, little is known about the risk factors for and outcomes of FA. To close these gaps in the literature, we designed the Food Addiction Denmark (FADK) Project.Methods:The FADK study is a nationwide survey with retrospective and prospective register-based elements. Four randomly sampled cohorts were invited to participate in the survey: 5000 adults and 3750 adolescents from the general population and 5000 adults and 3529 adolescents with a mental disorder. The FADK questionnaire includes the Yale Food Addiction Scale 2.0 and rating scales measuring psychopathology. Data from Danish health and socio-economic registers will be linked to all invitees.Discussion:We expect that the FADK Project will contribute significantly to our understanding of FA.

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“…A German study based on a combination of self-reports and examinations of common chronic conditions such as hypertension and diabetes found little evidence of a continuum of resistance ( Haring et al, 2009 ). An Australian study of screening for colorectal cancer found mixed evidence ( Gregory et al, 2013 ), but was limited by a small sample.…”

Section: Introductionmentioning

confidence: 99%

Examining the continuum of resistance model in two population-based screening studies in Sweden

Nilsson

Strömberg

Björk

et al. 2023

Preventive Medicine Reports

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Exploring the Validity of the Continuum of Resistance Model for Discriminating Early from Late and Non-uptake of Colorectal Cancer Screening: Implications for the Design of Invitation and Reminder Letters

Abstract: Background: This continuum of resistance model contends that respondents lie at one end of a continuum and

Cited by 6 publications

References 27 publications

A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia

A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia

The Food Addiction Denmark (FADK) Project: a combined survey and register-based study

Examining the continuum of resistance model in two population-based screening studies in Sweden

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