Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(ii)-based radiopharmaceuticals

Abstract

We report a detailed investigation on the use of chelators PYTAM, H4PYTAMGly, CHX-PYTAM and H4CHX-PYTAMGly for the complexation of Pb(II)-radioisotopes with potential use in the preparation of radiopharmaceuticals. The macrocyclic...

Improving the In Vivo Stability of [52Mn]Mn(II) Complexes with 18-Membered Macrocyclic Chelators for PET Imaging

“…The preparation of ligands PYAN and CHXPYAN was carried out following previously reported procedures. , While the Mn­(II) complex of PYAN was previously reported as the bromide salt, to the best of our knowledge, through a search of the CCDC database, the CHXPYAN complex had not. Reaction of the ligands with Mn­(NO 3 ) 2 in ethanol afforded the corresponding water-soluble Mn­(II) complexes, with high-resolution mass spectra and high-performance liquid chromatography (HPLC) analysis confirming their formation (Figures S1–S4, Supporting Information).…”

“…The solvents and reagents were of reagent grade and were purchased from commercial sources and used without further purification. Chelators PYAN and CHXPYAN were prepared according to previously reported procedures. , Both chelators were purified by semipreparative HPLC using H 2 O and CH 3 CN + 0.1% formic acid as the mobile phases to ensure sufficient purity for radiolabeling experiments (Table S2, Supporting Information).…”