Exploring the use of an anti-tick vaccine as a tool for the integrated eradication of the cattle fever tick, Rhipicephalus (Boophilus) annulatus

Miller, Robert J.; Estrada-Peña, Agustı́n; Almazán, Consuelo; Allen, Andrew G.; Jory, Lauren; Yeater, Kathleen M.; Messenger, Matthew T.; Ellis, Dee; León, Adalberto A. Pérez de

doi:10.1016/j.vaccine.2012.05.061

Cited by 34 publications

(37 citation statements)

References 19 publications

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“…Another study did not report which breed was used (JEYABAL et al, 2010). Only three studies controlled for the weight of the animals, and one of these failed to report the mean weight of the animals (ANDREOTTI, 2006(ANDREOTTI, , 2007MILLER et al, 2012). The experimental animals' ages ranged from 6 to 12 months, and six authors either did not control for or omitted this confounding variable.…”

Section: Resultsmentioning

confidence: 99%

“…Three articles reported having used statistical software. One of them only provided the software names without reporting the command or test used (KUMAR et al, 2012b), and one study, which used the statistical analysis software (SAS) platform, reported having used the Generalized Linear Mixed Model (GLMMIX) procedure (MILLER et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…The first 3 articles on cattle tick vaccines were published in this journal (CANALES et al, 1997;FRAGOSO et al, 1998;GARCÍA-GARCÍA et al, 2000). Years later, another 6 articles were published (ANDREOTTI et al, 2012;DE LA FUENTE et al, 2010;GALAÏ et al, 2012;HAJDUSEK et al, 2010;MERINO et al, 2011;MILLER et al, 2012). Notably, all studies were published in high impact journals in the fields of veterinary medicine, parasitology and animal health.…”

Section: Discussionmentioning

confidence: 99%

“…Even studies that used 3 or 4 animals per group were able to show significant differences in the biology of tick data between the vaccinated and control groups. Some authors used 5 bovine animals per group (GALAÏ et al, 2012;JEYABAL et al, 2010;KUMAR et al, 2012a, b;MILLER et al, 2012) and were able to show differences between the vaccinated and control groups in some of the biological parameters analyzed, with p<0.05. However, other authors who used 5 replicates per group (AZHAHIANAMBI et al, 2009a, b;CANALES et al, 2009) found no significance in the comparison test between the groups.…”

Section: Discussionmentioning

confidence: 99%

“…Only four studies reported the weights of the animals (ANDREOTTI, 2006(ANDREOTTI, , 2007ANDREOTTI et al, 2002;MILLER et al, 2012), and only one reported that the animals were weighed (FRAGOSO et al, 1998), although it failed to report whether the weight was blocked. The weight of an animal may indeed affect the results, not only because it reflects the body condition of an animal and its health status but also because smaller and leaner animals may not have the same susceptibility or resistance to ticks as heavier animals, especially considering the same breed, wherein contemporary animals usually have the same body pattern (DE LA FUENTE et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Calculation of the efficacy of vaccines against tick infestations on cattle

Cunha

Andreotti

Garcia

et al. 2013

Rev. Bras. Parasitol. Vet.

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Cattle ticks are responsible for great economic losses in cattle farming worldwide, and their main control method, chemicals, has been showing problems, whether resulting from the development of resistant strains of ticks or environmental contamination. Research studies directed toward developing vaccines against ticks are emerging. One way to evaluate those vaccines is to calculate the percentage of efficacy. The aim of this study was to analyze scientific publications archived in PubMed that used this method of assessment and discuss the main factors that may affect its calculation. Thus, 25 articles addressing this subject were selected. The percentage of efficacy was usually calculated in one of two ways, with one considering the reduced fertility of eggs and the other not. The latter method may underestimate the vaccine efficacy, and the most complete formula for calculating the efficacy reflects how much the vaccine actually affects the infestation. In our view, the use of the complete formula for calculating the percentage of efficacy is broader and more representative of the vaccine effect on the tick population.Keywords: Efficiency, ticks, vaccine, bovine. ResumoCarrapatos de bovinos são responsáveis por grandes perdas econômicas para a pecuária bovina mundial e seu principal método de controle, o químico, vem apresentando problemas, seja pelo desenvolvimento de amostras de carrapatos resistentes ou pela contaminação ambiental. Na tentativa de diminuir a utilização dos acaricidas, surgem pesquisas direcionadas ao desenvolvimento de vacinas contra carrapatos. Uma maneira de avaliar essas vacinas é pelo cálculo de percentagem de eficácia. O objetivo deste trabalho foi analisar as publicações científicas indexadas no PubMed que utilizaram este método de avaliação e discutir os principais fatores que podem interferir no seu cálculo. Dessa maneira, selecionaram-se 25 artigos que tratavam desse assunto. A percentagem de eficácia apareceu sendo calculada de duas formas, uma considerando a redução da fertilidade dos ovos e a outra não. Essa última pode subestimar a eficiência da vacina, e a fórmula de cálculo da eficácia mais completa representa o quanto da infestação a vacina realmente reduziu. Em nosso entendimento, a utilização da fórmula completa para o cálculo da percentagem de eficácia é mais abrangente e representativa do efeito da vacina na população de carrapatos.Palavras-chave: Eficiência, carrapato, vacina, bovino.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Calculation of the efficacy of vaccines against tick infestations on cattle

Cunha

Andreotti

Garcia

et al. 2013

Rev. Bras. Parasitol. Vet.

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Translating Ecology, Physiology, Biochemistry, and Population Genetics Research to Meet the Challenge of Tick and Tick‐borne Diseases in North America

Esteve-Gassent

Castro-Arellano

Feria-Arroyo

et al. 2016

Arch Insect Biochem Physiol

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Emerging and re-emerging tick-borne diseases threaten public health and the wellbeing of domestic animals and wildlife globally. The adoption of an evolutionary ecology framework aimed to diminish the impact of tick-borne diseases needs to be part of strategies to protect human and animal populations. We present a review of current knowledge on the adaptation of ticks to their environment, and the impact that global change could have on their geographic distribution in North America. Environmental pressures will affect tick population genetics by selecting genotypes able to withstand new and changing environments and by altering the connectivity and isolation of several tick populations. Research in these areas is particularly lacking in the southern US and most of Mexico with knowledge gaps on the ecology of these diseases, including a void in the identity of reservoir hosts for several tick-borne pathogens. Additionally, the way in which anthropogenic changes to landscapes may influence tick-borne disease ecology remains to be fully understood. Enhanced knowledge in these areas is needed in order to implement effective and sustainable integrated tick management strategies. We propose to refocus ecology studies with emphasis on metacommunity-based approaches to enable a holistic perspective addressing whole pathogen and host assemblages. Network analyses could be used to develop mechanistic models involving multi host-pathogen communities. An increase in our understanding of the ecology of tick-borne diseases across their geographic distribution will aid in the design of effective area-wide tick control strategies aimed to diminish the burden of pathogens transmitted by ticks.

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Quantitative models of Rhipicephalus (Boophilus) ticks: historical review and synthesis

et al. 2017

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Abstract. Several tick species, in what is now known as the subgenus Boophilus in the genusRhipicephalus, are economically important ectoparasites of livestock and other ungulates; as vectors of pathogens that kill cattle, they remain among the most studied ticks in the world. Researchers have developed quantitative computer models of Rhipicephalus ticks since the early 1970s to study complex biological and ecological relationships that influence management or eradication of ticks and tick-borne diseases. We review the 45-yr history of Rhipicephalus (Boophilus) models, which were developed and applied first in Australia, 10 yr later in North and South America, then soon after in Africa. Models progressed from analytical models of a portion of tick life cycles, to simulation models of complete life cycles or ecoclimatic indices, to the current emphasis on GIS-based bioclimatic envelope models estimated from remotely sensed data and tick presence records. Earlier models were used primarily to predict effects of management techniques, such as use of sterile hybrid ticks, pasture rotation, acaricides, vaccines, and resistant cattle, while more recent models have been used to predict the potential for range expansion, especially due to global climate change and wildlife hosts, as well as in the face of competition with other tick species. We summarize characteristics of these models and compare those of population dynamics and bioclimatic envelope models. We discuss the past and present utility of these models and provide a perspective on future Rhipicephalus (Boophilus) modeling efforts.

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Exploring the use of an anti-tick vaccine as a tool for the integrated eradication of the cattle fever tick, Rhipicephalus (Boophilus) annulatus

Cited by 34 publications

References 19 publications

Calculation of the efficacy of vaccines against tick infestations on cattle

Calculation of the efficacy of vaccines against tick infestations on cattle

Translating Ecology, Physiology, Biochemistry, and Population Genetics Research to Meet the Challenge of Tick and Tick‐borne Diseases in North America

Quantitative models of Rhipicephalus (Boophilus) ticks: historical review and synthesis

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