Exploring the unexpected behavior of HPMC matrix tablets in dissolution media with SDS

Rede, Katarina; Felicijan, Tjaša; Bogataj, Marija

doi:10.1016/j.jddst.2021.102801

Cited by 2 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to increase the drug release amount, we induce the internal network structure of the hydrogel by adding a surfactant. Surfactants are widely used to improve the rate of drug release in carriers. , Surfactants can accommodate poorly water-soluble drugs by forming micelles, which are amphiphilic molecules with hydrophilic and hydrophobic groups. Notably, an increase in the drug release rate was reported by adding surfactants to hydrophobic matrix pills .…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Drug-Encapsulated Protein Films with Various Sodium Dodecyl Sulfate Concentrations

et al. 2023

View full text Add to dashboard Cite

Protein-based drug carriers are ideal drug-delivery platforms because of their biocompatibility, biodegradability, and low toxicity. Many types and shapes of protein-based platforms, including nanoparticles, hydrogels, films, and minipellets, have been prepared to deliver drug molecules. In this study, protein films containing the desired amounts of doxorubicin (DOX) as cancer drugs were developed using a simple mixing method. The release ratio and rate of DOXs were dependent on the surfactant concentration. The drug release ratio was controlled within the range of 20–90% depending on the amount of the surfactant used. The protein film surface was analyzed using a microscope before and after drug release, and the relationship between the degree of film swelling and the drug release ratio was discussed. Moreover, the effects of cationic surfactants on the protein film were investigated. Non-toxic conditions of the protein films were confirmed in normal cells, while the toxicity of the drug-encapsulated protein film was confirmed in cancer cells. Remarkably, it was observed that the drug-encapsulated protein film could eliminate 10–70% of cancer cells, with the extent of efficacy varying based on the surfactant amount.

show abstract

Section: Introductionmentioning

confidence: 99%