Exploring the Trends of Acute Appendicitis Following Recovery or Vaccination From COVID-19

Tankel, James; Keinan, Aner; Gillis, Roni; Yoresh, Maya; Gillis, Michal; Tarnovsky, Yehuda; Riessman, Petachia

doi:10.1016/j.jss.2022.06.040

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…They described an incidence of appendicitis following COVID-19 vaccination that was not higher than expected within the general population [ 35 ]. Similar results were presented by Tankel et al, who studied the Danish population in 2021 and found no relationship between these two conditions [ 36 ].…”

Section: Discussionsupporting

confidence: 88%

Acute Appendicitis Following COVID-19 Infection in Pediatric Patients: A Single Center’s Study in Greece

et al. 2023

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Purpose: This study investigated the potential association between the previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive infection, as well as vaccination, and the presentation of acute appendicitis in pediatric patients. It has been three years since the World Health Organization (WHO) declared the SARS-CoV-2 pandemic, and city lockdowns and self-protective measures have been applied worldwide. In an effort to contribute to the research on the probable long-term complications of the COVID-19 infection as well as the vaccination against SARS-CoV-2, the current study was designed and investigated patients’ health records in the post-quarantine era. Methods: A retrospective analysis of patients admitted and treated surgically for acute appendicitis from January 2022 to June 2022 was conducted. Demographic and personal data, as well as the COVID-19 infection history of each child, were recorded. The patients who were negative for a previous COVID-19 infection were excluded. For the rest of the sample, the time-to-onset of acute appendicitis, the severity of appendicitis (complicated or uncomplicated), and the vaccination status of the patients were examined. Regarding the time-to-onset of appendicitis, we divided the patients into three groups: group A with a time-to-onset < 3 months, group B with a time-to-onset of 3–6 months, and group C with a time-to-onset of >6 months. Statistical analysis followed and was considered significant if p < 0.05. Results: Sixty-six children with a mean age of 10.5 years (range 1–15 years) were admitted for acute appendicitis during the determined period. After excluding 30 children that were negative for previous COVID-19 infection, we divided the patients into three groups: group A-23 children, group B-7 children, and group C-6 children. A statistically significant incidence of acute appendicitis diagnosis in <3 months after laboratory-confirmed COVID-19 infection (p < 0.01) was found. The incidence of complicated appendicitis was greater in patients with a positive SARS-CoV-2 history, with an estimated odds ratio of 1.8 (p > 0.05). The majority of the children (92%) had not received a COVID-19 vaccination. For the vaccinated children, the relative risk for complicated appendicitis was equal to 1.5 (p > 0.05). Conclusions: The results of our study demonstrate a potential positive relationship between COVID-19 infection and subsequent acute appendicitis in pediatric patients. There are also some speculations on the presentation of complicated cases of appendicitis following COVID-19 infection or vaccination, but these need to be further proven. Further data are required to better understand this potential complication of COVID-19 infection as well as the role of vaccines in the current post-vaccine era.

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Section: Discussionsupporting

confidence: 88%

Acute Appendicitis Following COVID-19 Infection in Pediatric Patients: A Single Center’s Study in Greece

et al. 2023

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“…That said, it should be mentioned that previous studies failed to find a relationship between vaccination against COVID-19 or recovery from the acute illness and both the nature and incidence of AA. 19 Finally, patients were managed by multiple surgeons, posing potential operator bias due to differences in threshold for conversion from nonoperative to surgical treatment, and surgical technique.…”

Section: Discussionmentioning

confidence: 99%

Higher Rates of Complicated Appendicitis During the COVID-19 Pandemic: A Year-to-Year Analysis

Kupietzky,

Finkin,

Dover

et al. 2023

Journal of Surgical Research

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Exploring the Trends of Acute Appendicitis Following Recovery or Vaccination From COVID-19

Cited by 2 publications

References 31 publications

Acute Appendicitis Following COVID-19 Infection in Pediatric Patients: A Single Center’s Study in Greece

Acute Appendicitis Following COVID-19 Infection in Pediatric Patients: A Single Center’s Study in Greece

Higher Rates of Complicated Appendicitis During the COVID-19 Pandemic: A Year-to-Year Analysis

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