Exploring the Therapeutic Potential of Cissampelos pareira in Wound Healing: A Comprehensive Investigation into its Anti-Inflammatory and Antioxidant Properties

Abstract

Aim: This study analyses the potential action of Cissampelos pareira in amelioration of wound healing. Materials and methods: A Carrageenan-induced acute inflammatory model was used for the induction of inflammation and excision wound model for creation of wounds in rats. The commencement of the chronic administration of different extracts of Cissampelos pareira CIAQ (Cissampelos pareira aqueous extract 200, 400 mg/kg), CIME (Cissampelos pareira methyl extract 200,400 mg/kg) for a period of 14 days after wound creation. Results: Administration of different extracts of Cissampelos pareira was found to have a significant ameliorating effect on wound healing, and a moderating effect on oxidative stress and inflammation. Conclusion: Cissampelos pareira may be helpful in treatment of chronic wound by reducing oxidative stress and inflammatory cytokines using Carrageenan-induced acute inflammatory and excision wound model.