Exploring the Therapeutic Mechanism of Jiangtang Sanhao Formula in Alleviating Insulin Resistance in Skeletal Muscle Cells: Involvement of AMPK/SIRT1/PGC-1α pathway?
Zimengwei Ye,
Yi Zhao,
Xin Fang
et al.
Abstract:Insulin resistance (IR) in skeletal muscle is a well-documented pathologic characteristic in the development of type 2 diabetes mellitus (T2DM), with GLUT4 being a key protein involved in this process. Jiangtang Sanhao formula, (JTSHF), a proven effective prescription for treating T2DM in clinic, has been shown to have a beneficial effect on alleviation of skeletal muscle IR. However, the underlying mechanism still need to be explored. Herein, we investigated the potential benefits and mechanism of JTSHF-conta… Show more
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