Exploring the Targets and Molecular Mechanisms of Thalidomide in the Treatment of Ulcerative Colitis: Network Pharmacology and Experimental
Validation
Jun Li,
Qin Tao,
Yang Xie
et al.
Abstract:Background:
Ulcerative colitis (UC) is a chronic, nonspecific, inflammatory disease of the intestine
with an unknown cause. Thalidomide (THA) has been shown to be an effective drug for the treatment of UC.
However, the molecular targets and mechanism of action of THA for the treatment of UC are not yet clear.
Objectives:
Combining network pharmacology with in vitro experiments, this study aimed to investigate the
potential targets and molecular mechanisms of THA for the treatment of UC.
Methods:
Firstly, r… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.