Exploring the Targets and Molecular Mechanisms of Curcumin for the Treatment of Bladder Cancer Based on Network Pharmacology, Molecular Docking and Molecular Dynamics

Li, Jun; Feng, Shujie; Wang, Xiong; Zhang, Bingmei; He, Qingmin

doi:10.1007/s12033-024-01190-x

Mol Biotechnol

2024

DOI: 10.1007/s12033-024-01190-x

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Exploring the Targets and Molecular Mechanisms of Curcumin for the Treatment of Bladder Cancer Based on Network Pharmacology, Molecular Docking and Molecular Dynamics

Jun Li,

Shujie Feng,

Xiong Wang

et al.

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Cited by 2 publications

References 72 publications

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Network Pharmacology Combined with Bioinformatics Analysis to Texplore the Potential Mechanism of Phellodendri Chinensis Cortex Against Bladder Cancer

Hu,

Wu,

Wang

et al. 2024

Cell Biochem Biophys

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Network Pharmacology Combined with Bioinformatics Analysis to Texplore the Potential Mechanism of Phellodendri Chinensis Cortex Against Bladder Cancer

Hu,

Wu,

Wang

et al. 2024

Cell Biochem Biophys

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Recent Development of Fluoroquinolone Derivatives as Anticancer Agents

Nowakowska,

Radomska,

Czarnomysy

et al. 2024

Molecules

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Cancer is the second leading cause of death in the world following cardiovascular disease. Its treatment, including radiation therapy and surgical removal of the tumour, is based on pharmacotherapy, which prompts a constant search for new and more effective drugs. There are high costs associated with designing, synthesising, and marketing new substances. Drug repositioning is an attractive solution. Fluoroquinolones make up a group of synthetic antibiotics with a broad spectrum of activity in bacterial diseases. Moreover, those compounds are of particular interest to researchers as a result of reports of their antiproliferative effects on the cells of the most lethal cancers. This article presents the current progress in the development of new fluoroquinolone derivatives with potential anticancer and cytotoxic activity, as well as structure–activity relationships, along with possible directions for further development.

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Exploring the Targets and Molecular Mechanisms of Curcumin for the Treatment of Bladder Cancer Based on Network Pharmacology, Molecular Docking and Molecular Dynamics

Cited by 2 publications

References 72 publications

Network Pharmacology Combined with Bioinformatics Analysis to Texplore the Potential Mechanism of Phellodendri Chinensis Cortex Against Bladder Cancer

Network Pharmacology Combined with Bioinformatics Analysis to Texplore the Potential Mechanism of Phellodendri Chinensis Cortex Against Bladder Cancer

Recent Development of Fluoroquinolone Derivatives as Anticancer Agents

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