Exploring the systemic delivery of a poorly water-soluble model drug to the retina using PLGA nanoparticles

Zhang, Enqi; Osipova, Nadezhda; Sokolov, Maxim; Maksimenko, Olga; Semyonkin, Aleksey; Wang, Minhui; Grigartzik, Lisa; Gelperina, Svetlana; Sabel, Bernhard A.; Henrich‐Noack, Petra

doi:10.1016/j.ejps.2021.105905

Cited by 4 publications

(4 citation statements)

References 65 publications

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Section: In Vivo Behavior Of Plga-cou6 Nanoparticlesmentioning

confidence: 73%

“…Indeed, the drug is supposed to be released sooner or later, whereas the label should be retained by the carrier as long as possible. Thus, in a recent study conducted by our group [80], coumarin 6 served as a model drug that, in concert with the above observations, was very loosely associated with the PLGA nanoparticles. However, being quickly released from the nanoparticles upon intravenous administration in mice, it was successfully delivered into the retina, whereas the nanoparticles remained associated with the blood capillary endothelial cells (Figure 11).…”

Section: In Vivo Behavior Of Plga-cou6 Nanoparticlesmentioning

confidence: 73%

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Fluorescently Labeled PLGA Nanoparticles for Visualization In Vitro and In Vivo: The Importance of Dye Properties

et al. 2021

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Fluorescently labeled nanoparticles are widely used for evaluating their distribution in the biological environment. However, dye leakage can lead to misinterpretations of the nanoparticles’ biodistribution. To better understand the interactions of dyes and nanoparticles and their biological environment, we explored PLGA nanoparticles labeled with four widely used dyes encapsulated (coumarin 6, rhodamine 123, DiI) or bound covalently to the polymer (Cy5.5.). The DiI label was stable in both aqueous and lipophilic environments, whereas the quick release of coumarin 6 was observed in model media containing albumin (42%) or liposomes (62%), which could be explained by the different affinity of these dyes to the polymer and lipophilic structures and which we also confirmed by computational modeling (log PDPPC/PLGA: DiI—2.3, Cou6—0.7). The importance of these factors was demonstrated by in vivo neuroimaging (ICON) of the rat retina using double-labeled Cy5.5/Cou6-nanoparticles: encapsulated Cou6 quickly leaked into the tissue, whereas the stably bound Cy.5.5 label remained associated with the vessels. This observation is a good example of the possible misinterpretation of imaging results because the coumarin 6 distribution creates the impression that nanoparticles effectively crossed the blood–retina barrier, whereas in fact no signal from the core material was found beyond the blood vessels.

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Section: In Vivo Behavior Of Plga-cou6 Nanoparticlesmentioning

confidence: 73%

Section: In Vivo Behavior Of Plga-cou6 Nanoparticlesmentioning

confidence: 73%

Fluorescently Labeled PLGA Nanoparticles for Visualization In Vitro and In Vivo: The Importance of Dye Properties

et al. 2021

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“…Poly (lactic-co-glycolic acid) (PLGA) consists of Lactic Acid (LA) and Glycolic Acid (GA) monomers polymerized in the desired ratio, with good biodegradability and biocompatibility, it has also been approved by the US Food and Drug Administration (FDA) for medical applications [9,10]. It is used as a carrier for antimicrobial delivery, encapsulating the drug inside the carrier, protecting these agents from enzymatic and molecular damage and improving the therapeutic effi ciency of the drug [11][12][13]. Moreover it can solve the problems of drug stability, solubility and bioavailability [12,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…It is used as a carrier for antimicrobial delivery, encapsulating the drug inside the carrier, protecting these agents from enzymatic and molecular damage and improving the therapeutic effi ciency of the drug [11][12][13]. Moreover it can solve the problems of drug stability, solubility and bioavailability [12,14,15]. Thus PLGA as carrier, which can eff ectively solve the problems faced in drug delivery, have great potential for biomedical applications [16,17].…”

Section: Introductionmentioning

confidence: 99%

PLGA Nanoparticles with Cannabidiol for Efficient and Durable Antibacterial Applications

Cheng,

Ma,

Tang

et al. 2023

J Biomed Res Environ Sci

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The Cannabidiol (CBD) are extensively used owing to their potent antibacterial effects. We developed CBD-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles using an emulsion process technology, resulting informing the PLGA@CBD nanoparticles. The emulsion parameters were optimized using three-dimensional surface plots. When scaled up under optimal conditions, the corresponding loading content efficiency were 16.51%. Compared with natural cannabidiol, the physically modified PLGA nanoparticles became smooth, round, and solid, improving their water solubility and bioavailability, realizing long-time antibacterial. Therefore, the nanoparticles showed better efficacy against Gram-positive bacteria. Our results confirm that the PLGA@CBD nanoparticles have been achieved as long-acting antibacterial delivery system, which improved the treatment efficiency.

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Research Progress on Immunomodulatory Effects of Poly (Lactic-co- Glycolic Acid) Nanoparticles Loaded with Traditional Chinese Medicine Monomers

Song,

Chen,

Tong

et al. 2024

CDD

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Immunomodulatory mechanisms are indispensable and key factors in maintaining the balance of the environment in humans. When the immune function of the immune system is impaired, autoimmune diseases occur. Excessive body fatigue, natural aging of the human body, malnutrition, genetic factors and other reasons cause low immune function, due to which the body is prone to being infected by bacteria or cancer. Clinically, the existing therapeutic drugs still have problems such as high toxicity, long treatment cycle, drug resistance and high price, so we still need to explore and develop a high efficiency and low toxicity drug. Poly(lactic-co-glycolic acid) (PLGA) refers to a non-toxic polymer compound that exhibits excellent biocompatibility. Traditional Chinese medicine (TCM) monomers come from natural plants, and have the characteristics of high efficiency and low toxicity. Applying PLGA to TCM monomers can make up for the defects of traditional dosage forms, improve bioavailability, reduce the frequency and dosage of drug use, and reduce toxicity and side effects, thus having the characteristics of sustained release and targeting. Accordingly, PLGA nano-particles loaded with TCM monomers have been the focus of development. The previous research on drug loading advantages, preparation methods, and immune regulation of TCM PLGA nanoparticles is summarized in the following sections.

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Exploring the systemic delivery of a poorly water-soluble model drug to the retina using PLGA nanoparticles

Cited by 4 publications

References 65 publications

Fluorescently Labeled PLGA Nanoparticles for Visualization In Vitro and In Vivo: The Importance of Dye Properties

Fluorescently Labeled PLGA Nanoparticles for Visualization In Vitro and In Vivo: The Importance of Dye Properties

PLGA Nanoparticles with Cannabidiol for Efficient and Durable Antibacterial Applications

Research Progress on Immunomodulatory Effects of Poly (Lactic-co- Glycolic Acid) Nanoparticles Loaded with Traditional Chinese Medicine Monomers

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