Exploring the structure–property relationships of ultrasonic/MRI dual imaging magnetite/PLA microbubbles: magnetite@Cavity versus magnetite@Shell systems

Xu, Bin; Lü, Rong; Dou, Hongjing; Tao, Ke; Qiu, Yuanyuan; Ding, Jing; Zhang, Dong; Li, Jiyu; Shi, Wei; Kim, Sun

doi:10.1007/s00396-012-2682-2

Cited by 11 publications

(3 citation statements)

References 48 publications

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“…US/MRI dual modal microbubbles have been the most widely explored of all US‐multimodal contrast agents. These microbubbles are typically composed of SPIONs or gadolinium loaded into the shell of microbubbles . Much of the research in using MRI microbubbles stems from the idea that the agent can have a synergistic effect on the imaging contrast of each modality.…”

Section: Micrometer Scale Agentsmentioning

confidence: 99%

Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy

Huynh

Rajora

Zheng

2016

WIREs Nanomed Nanobiotechnol

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Ultrasound (US) is one of the most commonly used clinical imaging techniques. However, the use of US and US-based intravenous agents extends far beyond imaging. In particular, there has been a surge in the fabrication of multimodality US contrast agents and theranostic US agents for cancer imaging and therapy. The unique interaction of US waves with microscale and nanoscale agents has attracted much attention in the development of contrast agents and drug-delivery vehicles. The dimensions of the agent not only dictate how it behaves in vivo, but also how it interacts with US for imaging and drug delivery. Furthermore, these agents are also unique due to their ability to convert from the nanoscale to the microscale and vice versa, having imaging and therapeutic utility in both dimensions. Here, we review multimodality and multifunctional US-based agents, according to their size, and also highlight recent developments in size conversion US agents. WIREs Nanomed Nanobiotechnol 2016, 8:796-813. doi: 10.1002/wnan.1398 For further resources related to this article, please visit the WIREs website.

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Section: Micrometer Scale Agentsmentioning

confidence: 99%

Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy

Huynh

Rajora

Zheng

2016

WIREs Nanomed Nanobiotechnol

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“…Microbubbles can potentially be used as carriers for nanoscale US contrast agents and the incorporation of multimodal probes with potential therapeutic applications: sonodynamic therapy, ultrasound-induced apoptosis, sonoporation/sonotransfection, ultrasound-induced drug/gas delivery, and focused ultrasound-induced thermal ablation [32,33,280,[292][293][294][295][296][297][298][299].…”

Section: Ultrasound (Us)mentioning

confidence: 99%

“…Raman imaging helped for guidance of intraoperative tumor resection because it could accurately delineate the tumor margins. [456] Magnetite and PLA microbubbles [293] iron oxide and 64 Cu [36,173,175] CT/Fluorescence TaO x NPs and rhodamine-B [457] CT/PAT Gold@PEG NPs [239,343] CT/NIRF NaYbF 4 and Tm 3+ [263] PET/NIRF QDs and 64 Cu DOTA [205] PAT/US Gold nanorods and microbubbles [32] Gold Nnanorods [458] SPECT/fluorescence See reviews [439,459] TAT PET-CT/MRI/NIRF 64 Cu and Iron oxide and NIR dye [202] a MM-OCT: magnetomotive optical coherence tomograph.…”

Section: Multimodal Nanoprobesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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A novel method to in situ synthesis of magnetic poly(N-isopropylacrylamide-co-acrylic acid) nanogels

Zhao

et al. 2016

Colloid Polym Sci

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Exploring the structure–property relationships of ultrasonic/MRI dual imaging magnetite/PLA microbubbles: magnetite@Cavity versus magnetite@Shell systems

Cited by 11 publications

References 48 publications

Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy

Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

A novel method to in situ synthesis of magnetic poly(N-isopropylacrylamide-co-acrylic acid) nanogels

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