Exploring the role of testosterone in the cerebellum link to neuroticism: From adolescence to early adulthood

Schutter, Dennis J.L.G.; Meuwese, Rosa; Bos, Marieke; Crone, Eveline A.; Peper, Jiska S.

doi:10.1016/j.psyneuen.2017.01.009

Cited by 23 publications

(26 citation statements)

References 101 publications

(98 reference statements)

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“…These data replicate the findings from our previous cross‐sectional study in adolescents (Peper, Koolschijn, et al., Schutter et al., ) and correspond with findings in other cross‐sectional samples (Op de Macks et al., ). A possible underlying mechanism could be that testosterone binds to androgen receptors in limbic brain areas, which are implicated in risky behavior (Peper & Dahl, ).…”

Section: Discussionsupporting

confidence: 90%

“…With respect to the self‐report data, we observed that higher testosterone levels in males were associated with fewer behavioral avoidance‐related characteristics, such as neuroticism and behavioral inhibition/punishment sensitivity (BIS‐scale). The potentially “suppressing” effect of testosterone on behavioral avoidance or punishment sensitivity is similar to earlier reports, including lowered fear and anxiety‐like traits during adolescence (Enter, Terburg, Harrewijn, Spinhoven, & Roelofs, ; Schutter et al., ). Interestingly, both neuroticism and behavioral inhibition/punishment sensitivity were negatively correlated with risk taking and delay discounting.…”

Section: Discussionsupporting

confidence: 86%

“…Since these studies did not directly measure sex hormonal levels, the effect of changes in sex steroid levels over time on changes in risk‐taking behavior remains unknown. Our previous cross‐sectional studies showed that testosterone (but not estradiol) is related to increased risk‐taking behavior on the Balloon Analogue Risk‐Taking Task (BART; Peper, Koolschijn, & Crone, ) and to lower avoidance‐related personality characteristics, such as neuroticism (Schutter, Meuwese, Bos, Crone, & Peper, ). Increased estradiol was related to higher impulsive aggression in boys (Peper, de Reus, van den Heuvel, & Schutter, ).…”

mentioning

confidence: 99%

“…The selection of tasks was motivated by prior studies that included self‐report and laboratory assessments to test for their common relations as well as different developmental time courses. Self‐report measures included the Barratt Impulsiveness Scale, Version 11 (BIS–11), a measure of impulsivity; the Behavioral Inhibition (BIS)/Behavioral Activation (BAS) scale to assess avoidance and approach behaviors; the Buss Perry Aggression (BPA) questionnaire to test for impulsiveness in the aggressive domain (Zuckerman & Kuhlman, ); and the Neuroticism‐Extraversion‐Openness‐Personality Inventory (NEO‐PI) neuroticism scale, as this measure is found to be inversely related to risk taking and testosterone levels (Schutter et al., ). Experimental laboratory tasks included a delay discounting task to measure impulsive decision making (Achterberg et al., ) and the Balloon Analogue Risk Taking (BART) task to assess risk taking (Lejuez et al., ; Peper, Koolschijn, et al., ).…”

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confidence: 99%

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Development of Multifaceted Risk Taking and the Relations to Sex Steroid Hormones: A Longitudinal Study

et al. 2018

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Risk taking is a multidimensional construct. It is currently unclear which aspects of risk-taking change most during adolescence and if/how sex hormones contribute to risk-taking tendencies. This study applied a longitudinal design with three time-points, separated by 2 years, in participants aged 8-29 years (670 observations). The Balloon Analogue Risk Task, a delay discounting task, and various self-report questionnaires were administered, to measure aspects of risk taking. Longitudinal analyses demonstrated mostly nonlinear age-related patterns in risk-taking behavior and approach-related personality characteristics (peaking in late adolescence). Increased testosterone and estradiol were found to increase risk-taking behavior and impulsive personality, but decrease avoidance-like personality. This study demonstrates that risk taking is most pronounced in mid-to-late adolescence and suggests that sex hormones accelerate this maturational process.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

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confidence: 99%

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confidence: 99%

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Development of Multifaceted Risk Taking and the Relations to Sex Steroid Hormones: A Longitudinal Study

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“…In a replication of their earlier study, Schutter et al (2017) examined the relation of depression and anxiety subscales from the NEO-PI-R Neuroticism factor in 149 healthy volunteers. To extend this research they also included a measure of Behavioural Inhibition.…”

Section: Structural Imaging Studiesmentioning

confidence: 98%

From general factors to response generalisation: the importance of the cerebellum for mental health and social effectiveness

Walsh¹

2020

Preprint

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Various psychometric general factor models exist to describe a diverse range of human psychological traits e.g. general factors of intelligence, personality and psychopathology. Historically, these latent traits have been viewed and studied as distinct constructs. However, accumulating evidence demonstrates empirical overlap, and conceptual proposals have been made arguing that collectively these traits form a marker of general social effectiveness. Here I argue that the cerebellum has an important, and previously neglected role in supporting diverse general factor psychological traits that enable such social effectiveness. In this conceptual article, I review evidence derived largely from neuroimaging studies, that these general traits (intelligence, personality, psychopathology and others) share overlapping neural correlates, and potentially shared underlying computations in the cerebellum. This is important as the cerebellum has an integrative role in skilled behaviour and psychological flexibility by enabling cognitive, affective and behavioural generalisation and adaptation across diverse environmental contexts. This article also discusses the importance of the cerebellum for understanding general factor development, given the early maturational timing of the cerebellum, and high sensitivity to early environmental influence. Finally, I propose a cerebellar role within the Hierarchical Taxonomy of Psychopathology (HiToP); an important framework for understanding of the latent transdiagnostic structure of psychopathology. If correct, consideration of the cerebellum can facilitate integration of psychometric and translational neuroscience perspectives to provide a broader and unified biopsychosocial understanding of psychological, and specifically mental health phenomena.

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Inhibition of androgenic pathway impairs encoding of cerebellar‐dependent motor learning in male rats

Panichi

Dieni

Sullivan

et al. 2022

J of Comparative Neurology

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Cerebellar-dependent learning is essential for the adaptation of motor and no motor behaviors to changing contexts, and neuroactive steroids-mainly referred to as estrogens-may regulate this process. However, the role of androgens in this process has not been established, although they may affect cerebellar physiology. Thus, this study aims to determine whether the activation of androgenic neural pathways may take part in controlling the vestibuloocular (VOR) and optokinetic reflexes (OKR), which depend on a defined cerebellar circuitry. To answer this question, we acutely blocked the activation of androgen receptors (Ars) using systemic administration of the Ars antagonist flutamide (FLUT; 20 mg/Kg) in peripubertal male rats. Then, we evaluated the FLUT effect on general oculomotor performance in the VOR and OKR as well as VOR adaptive gain increases and decreases. We used a paradigm causing fast VOR adaptation that combined in phase/out phase visuo-vestibular stimulations. We found that FLUT impaired the gain increase and decrease in VOR adaptation. However, FLUT altered neither acute nor overtime basal ocular-motor performance in the VOR or OKR. These findings indicate that the activation of androgenic neural pathways participates in phenomena leading to fast VOR adaptation, probably through the modulation of plasticity mechanisms that underlie adaptation of this reflex. Conversely, androgens may not be essential for neural information processing demands in basal ocular-motor reflexes. Moreover, our results suggest that androgens, possibly testosterone and dihydrotestosterone, could rapidly regulate motor memory encoding in the VOR adaptation, acting at both cerebellar and extracerebellar plasticity sites.

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Exploring the role of testosterone in the cerebellum link to neuroticism: From adolescence to early adulthood

Cited by 23 publications

References 101 publications

Development of Multifaceted Risk Taking and the Relations to Sex Steroid Hormones: A Longitudinal Study

Development of Multifaceted Risk Taking and the Relations to Sex Steroid Hormones: A Longitudinal Study

From general factors to response generalisation: the importance of the cerebellum for mental health and social effectiveness

Inhibition of androgenic pathway impairs encoding of cerebellar‐dependent motor learning in male rats

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