Exploring the Role of Killer Cell Immunoglobulin-Like Receptors and Their HLA Class I Ligands in Autoimmune Hepatitis

Littera, Roberto; Chessa, Luchino; Onali, Simona; Figorilli, Francesco; Lai, Sara; Secci, L; Nasa, Giorgio La; Caocci, Giovanni; Arras, Marcella; Melis, Maurizio; Cappellini, S.; Balestrieri, Cinzia; Serra, Giancarlo; Conti, Maria; Zolfino, T.; Casale, Michele; Casu, Stefania; Pasetto, Maria Cristina; Barca, L; Salustro, C.; Matta, Laura; Scioscia, Rosetta; Zamboni, Fausto; Faa, Gavino; Orrù, Sandro; Carcassi, Carlo

doi:10.1371/journal.pone.0146086

Cited by 25 publications

(23 citation statements)

References 61 publications

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“…These interesting data point towards a hypothetical role for the telomeric B region (which contains both KIR2DS5 and KIR2DS1) in these diseases. In this context, the activating KIR gene KIR2DS1 has also very recently been reported to have an important predictive potential for early onset of Type 1 autoimmune hepatitis . Similar findings concerning KIR2DS1 and KIR2DS5 and skin cancer risk have also recently been reported .…”

Section: Discussionsupporting

confidence: 63%

Killer immunoglobulin‐like receptor repertoire analysis in a Caucasian Spanish cohort with inflammatory bowel disease

López-Hernández¹,

Campillo²,

Legáz³

et al. 2016

Microbiology and Immunology

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Immunological molecules are implicated in inflammatory disorders, including inflammatory bowel disease (IBD; Crohn disease [CD] and ulcerative colitis [UC]). Killer cell immunoglobulin-like receptors (KIRs) are also genetically variable proteins involved in immune function. They are expressed by NK cells and certain T lymphocytes, regulate specificity and function by interaction with HLA Class I molecules, may be either inhibitory or activating and are polymorphic both in terms of alleles and haplotype gene content. Genetic associations between activating KIRs and certain autoimmune and inflammatory diseases have been reported; however, a possible association between KIR and IBD remains unclear. The aim of this study was to determine the relationship between KIR repertoire and IBD pathologies in a Spanish cohort. KIR variability was analyzed using PCR-sequence specific oligonucleotide probes (SSOP). Inhibitory KIR2DL5 was found more frequently in UC and IBD patient groups than in healthy controls (P = 0.028 and P = 0.01, respectively), as was activating KIR2DS1 (P = 0.02, Pc > 0.05, UC vs. Controls; P = 0.001, Pc = 0.01, IBD vs Controls; P = 0.01, Pc > 0.05, Controls vs CR), KIR2DS5 (P = 0.0028, Pc = 0.04, Controls vs UC; P = 0.0001, Pc = 0.0017, Controls vs IBD; P = 0.01, Pc > 0.05, Controls vs CD) and KIR3DS1 (P = 0.012, Pc > 0.05, Controls vs IBD). Our data suggest that imbalance between activating and inhibitory KIR may partially explain the different pathogeneses of these IBDs and that there is a hypothetical role for the telomeric B region (which contains both KIR2DS5 and KIR2DS1) in these diseases.

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Section: Discussionsupporting

confidence: 63%

Killer immunoglobulin‐like receptor repertoire analysis in a Caucasian Spanish cohort with inflammatory bowel disease

López-Hernández¹,

Campillo²,

Legáz³

et al. 2016

Microbiology and Immunology

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“…Recently, HLA-B*18:01A was found in a Sardinian cohort of patients with type 1 autoimmune hepatitis [9], and an association between HLA DR52 and different immune-mediated inflammatory disease was also reported [10]. Some authors suggested that immunological abnormalities play a role also in ALS pathophysiology [2], also taking into account the presence of particular HLA aplotypes.…”

Section: Discussionmentioning

confidence: 97%

Multiple sclerosis and amyotrophic lateral sclerosis: a human leukocyte antigen challenge

et al. 2017

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Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are two different central nervous system pathology that, according to the most accredited hypotheses, recognize a different etiopathogenesis. The simultaneous occurrence of MS and ALS is quite unusual. To our knowledge, only three cases have been so far described by clinical, laboratory, and post-mortem studies. We report four new cases of this peculiar combination that have been observed and are herein described, included their human leukocyte antigen (HLA) profile studies. On the basis that three out of four patients in our case series presented HLA-B*18:01A, we may hypothesize that this antigen could play a role in developing both diseases.

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“…The latter are a family of receptors expressed on NK cells and T-cells and play regulatory roles in their activation [9]. The KIR2DL1 inhibitory receptor and the KIR2DS1 activating receptor identify molecules of the C2 group [79]. Patients with psoriatic arthritis that express either the homozygous HLA-C1 group or homozygous HLA-C2 group show less inhibitory KIR activity.…”

Section: Cd8+ T-cellsmentioning

confidence: 99%

Elucidating the Molecular Basis of Multiple Sclerosis and Understanding the Disease Pathophysiology

Eiman¹

2016

Immunome Res

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Multiple sclerosis (MS) is a complex, multifactorial autoimmune disorder of the central nervous system (CNS) that causes inflammation, demyelination and neurodegeneration. The increased prevalence of this disease in Arabian Gulf Countries (AGCs) has captivated the author. The following is a deliberative review of the disease with respect to its molecular basis. Briefly, it considers disease pathophysiology though the molecular composition of the cell; the genome, epigenome and mitochondrial genome; and relates these factors to environmental, etiological factors, including: vitamin D, UVR, EBV infection, smoking and obesity. All in all, this review aims to explain the reasons underlying the increasing prevalence of MS in AGCs.

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Exploring the Role of Killer Cell Immunoglobulin-Like Receptors and Their HLA Class I Ligands in Autoimmune Hepatitis

Cited by 25 publications

References 61 publications

Killer immunoglobulin‐like receptor repertoire analysis in a Caucasian Spanish cohort with inflammatory bowel disease

Killer immunoglobulin‐like receptor repertoire analysis in a Caucasian Spanish cohort with inflammatory bowel disease

Multiple sclerosis and amyotrophic lateral sclerosis: a human leukocyte antigen challenge

Elucidating the Molecular Basis of Multiple Sclerosis and Understanding the Disease Pathophysiology

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