Exploring the Role of Dairy Products In Sleep Quality: From Population Studies to Mechanistic Evaluations

St‐Onge, Marie‐Pierre; Zuraikat, Faris M.; Neilson, Mackenzie

doi:10.1016/j.advnut.2023.01.004

Cited by 3 publications

(1 citation statement)

References 74 publications

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“…Food and active ingredients have received a lot of attention in terms of disease prevention and treatment. Dairy products have long been regarded as natural sleep aids [5] . Goat milk is a great dietary source.…”

Section: Introductionmentioning

confidence: 99%

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

Mo,

Jing,

et al. 2024

Food Science and Human Wellness

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Insomnia is associated with neurotransmitters and intestinal dysbiosis. Though studies have demonstrated the ameliorative effects of milk hydrolysates on insomnia, the underlying mechanisms require further exploration. In this study, we investigated how papain hydrolysates of goat casein (CPH) and whey protein (WPH) affected mice's sleeplessness. Here, we show that CPH effectively improved the total sleep time in 12 h and restoring neurotransmitters (5-hydroxytryptamine (5-HT), γ-aminobutyric acid (GABA), dopamine (DA), and norepinephrine (NE)) in mice. Further gut microbiota analysis revealed a significant increase in the relative abundance of Helicobacter and Escherichia-Shigella and a decrease in the relative abundance of Lactobacillus in the insomnia model mice (Model). Compared to the Model group, both CPH and WPH significantly increased the relative abundance of Akkermansia and Lactobacillus while lowering the relative abundance of Helicobacter and Escherichia-Shigella. Notably, while diazepam (DZP) increased mouse sleep duration, it also increased the relative abundance of Colidextribacter, Parasutterella, Muribaculaceae, and Prevotella. Additionally, the gene expression and protein expression of GABAA receptor, cAMP-response element binding protein (CREB), and brain-derived neurotrophic factor (BDNF) were upregulated in the hypothalamus. We also discovered a link between intestinal gut microbiota and neurotransmitters. Overall, our results suggest that goat milk hydrolysates, especially CPH, can effectively improve insomnia, providing a theoretical basis for further experimentation and individualized designs.

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Section: Introductionmentioning

confidence: 99%

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

Mo,

Jing,

et al. 2024

Food Science and Human Wellness

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Properties of milk in sleep induction

Ortega,

Jiménez-Ortega,

Martínez García

et al. 2023

Nutr Hosp

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Assessment of preoperative health-related quality of life in patients undergoing thyroidectomy based on patient-reported outcomes

Liu,

Xiang,

Xiong

et al. 2024

Front. Psychol.

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IntroductionTo evaluate the preoperative health-related quality of life (HRQoL) and influencing factors of HRQoL in patients undergoing thyroidectomy based on patient-reported outcomes.Materials and methodsPatients who were diagnosed and treated in Sichuan Cancer Hospital from February 2022 to December 2022 and were scheduled to undergo thyroidectomy were included. Each participant completed the basic information questionnaire and patient-reported outcome assessment scales before surgery. HRQoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30), the Thyroid Cancer-Specific Quality of Life (THYCA-QoL), and the Hamilton Anxiety Scale (HAMA). The Wilcoxon rank sum test or the Kruskal-Wallis test was used to analyze the association between patient characteristics and HRQoL, and the variables with statistical significance were included in multiple linear regression analysis.Results450 patients were included in the study. According to the analysis of the THYCA-QoL scores, the psychological subscale was the most complained about. Anxiety was the most common symptom of the HAMA. Factors associated with worse general QoL on the EORTC QLQ-C30 included nondiagnostic/unsatisfactory fine-needle aspiration (FNA) result. Planned lateral neck dissection and nondiagnostic/unsatisfactory FNA result were influential factors for preoperative anxiety. Males and longer sleep duration were associated with better thyroid cancer-specific QoL, better general QoL, and less anxiety.ConclusionThe preoperative HRQoL of patients undergoing thyroidectomy was generally good. Females, insufficient sleep duration, planned lateral neck dissection, and nondiagnostic/unsatisfactory FNA result were associated with worse preoperative HRQoL.

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Exploring the Role of Dairy Products In Sleep Quality: From Population Studies to Mechanistic Evaluations

Cited by 3 publications

References 74 publications

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

Properties of milk in sleep induction

Assessment of preoperative health-related quality of life in patients undergoing thyroidectomy based on patient-reported outcomes

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