Exploring the Role of Amino Acid-Derived Multivariate Metal–Organic Frameworks as Catalysts in Hemiketalization Reactions

Abstract

Understanding the host−guest chemistry in MOFs represents a research field with outstanding potential to develop in a rational manner novel porous materials with improved performances in fields such as heterogeneous catalysis. Herein, we report a family of three isoreticular MOFs derived from amino acids and study the influence of the number and nature of functional groups decorating the channels as a catalyst in hemiketalization reactions. In particular, a multivariate (MTV) MOF 3, prepared by using equal percentages of amino acids L-serine and L-mecysteine, in comparison to single-component ("traditional") MOFs, derived from either L-serine or L-mecysteine (MOFs 1 and 2), exhibits the most efficient catalytic conversions for the hemiketalization of different aldehydes and ketalization of cyclohexanone. On the basis of the experimental data reported, the good catalytic performance of MTV-MOF 3 is attributed to the intrinsic heterogeneity of MTV-MOFs. These results highlight the potential of MTV-MOFs as strong candidates to mimic natural nonacidic enzymes, such as glycosidases, and to unveil novel catalytic mechanisms not so easily accessible with other microporous materials.

Thiol and thioether-based metal–organic frameworks: synthesis, structure, and multifaceted applications

“…Pardo and co-workers extensively work on thioether-based MOFs and their catalytic efficiency. 92–94 The strong affinity of the thioether group was utilized by Mon et al by anchoring a Au salt in BioMOF {Ca II Cu II 6 [( S , S )-methox] 3 (OH) 2 (H 2 O)}·9H 2 O to synthesize heterogeneous catalysts Au III BioMOF and Au I BioMOF (Table 9, entry no. 11).…”