Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction

Abstract

Background: A number of motor abnormalities have been reported in psychotic disorders, including dyskinesia and psychomotor slowing. There is also evidence for many of the same motor abnormalities in biological first-degree relatives and accruing evidence for motor abnormalities in bipolar disorder. In addition to motor dysfunction, there are also shared symptom domains amongst these populations. Objectives: We explored the associations of (1) current and lifetime psychosis and mood symptom domains and (2) domains of psychosis proneness with various domains of motor function in a transdiagnostic sample (n = 149). Method: Individuals with schizophrenia, schizoaffective disorder, or bipolar disorder, biological first-degree relatives of individuals with a psychotic disorder, and controls completed measures of psychomotor speed and movement fluidity, and neural activity related to motor preparation (stimulus-locked lateralized readiness potential, S-LRP) and execution (response-locked LRP) was assessed using EEG. All participants completed the Brief Psychiatric Rating Scale; patients were additionally assessed for lifetime psychosis and mood episode symptoms, and relatives and controls completed the Chapman psychosis proneness scales. Results: Multiple regression revealed levels of current negative symptoms and mania were significantly positively associated with psychomotor slowing even after accounting for current antipsychotic medication dosage and duration of illness. S-LRP onset latency was significantly positively associated with magical ideation. Conclusion: Domains of motor function are associated with various mood and psychosis symptom domains in a transdiagnostic sample, which may provide insight into brain abnormalities relevant to the expression of symptoms across disorders.

Lifetime and point prevalence of psychotic symptoms in adults with bipolar disorders: a systematic review and meta-analysis

“…There were 54 studies ( n = 23 461) reporting data on the lifetime prevalence of psychotic symptoms in BD, for an overview of included studies see online Supplementary Material 4: Studies included in the meta-analyses of the lifetime prevalence of psychotic symptoms in bipolar disorders (Aedo et al, 2018; Altindag, Yanik, & Nebioglu, 2006; Atagun et al, 2018; Balzafiore et al, 2017; Berkol, Kirli, Islam, Pinarbasi, & Ozyildirim, 2016; Bolhuis et al, 2021; Burton et al, 2018; Cao et al, 2014; Davila et al, 2006; Dell'Osso et al, 2010, 2015; Ekman et al, 2017; Ernst & Goldberg, 2004; Finseth, Morken, Andreassen, Malt, & Vaaler, 2012; Fuentes, Rizo-Mendez, & Jarne-Esparcia, 2016; Gesi et al, 2016; Goldberg et al, 1999; Gonzalez-Pinto et al, 2011; Grande et al, 2017; Grigoroiu-Serbanescu et al, 2010; Jamra et al, 2010; Javadapour et al, 2010; Karakus & Tamam, 2011; Kent et al, 2020; Kirov & Murray, 1999; Knorr et al, 2021; Laidi et al, 2015; Lee & Kim, 2011; Mantere et al, 2004; Miller et al, 2018; Moon et al, 2012; Nardi et al, 2008; Neves, Malloy-Diniz, Barbosa, Brasil, & Correa, 2009; Newport et al, 2012; Ong et al, 2012; Ortiz et al, 2021; Østergaard, Bertelsen, Nielsen, Mors, & Petrides, 2013; Pacchiarotti et al, 2011; Parker et al, 2013, 2020; Patterson, Sandman, Ring, Jin, & Bunney, 2009; Prabhavathy, Kuruvilla, Ravindren, Ganesh, & Midhun, 2017; Sanchez-Morla et al, 2019; Sarrazin et al, 2018; Savitz et al, 2015; Simonsen et al, 2011; Talati et al, 2013; Tost et al, 2010; Trotti et al, 2020; Tundo et al, 2015; Van Der Werf-Eldering et al, 2011; Van Rheenen et al, 2017; Yazici, Kora, Ucok, Tunali, & Turan, 1999; Yilmaz, Yavuz, Altinbas, Lordoglu, & Kurt, 2015).…”

“…The pooled lifetime prevalence of psychotic symptoms in the 51 included DSM BD studies ( N = 8013) was 57% (95% CI 52–62) (Aedo et al, 2018; Altindag et al, 2006; Atagun et al, 2018; Balzafiore et al, 2017; Berkol et al, 2016; Burton et al, 2018; Cao et al, 2014; Davila et al, 2006; Dell'Osso et al, 2010, 2015; Ekman et al, 2017; Ernst & Goldberg, 2004; Finseth et al, 2012; Fuentes et al, 2016; Gesi et al, 2016; Goldberg et al, 1999; Gonzalez-Pinto et al, 2011; Grande et al, 2017; Grigoroiu-Serbanescu et al, 2010; Jamra et al, 2010; Javadapour et al, 2010; Karakus & Tamam, 2011; Kent et al, 2020; Kirov & Murray, 1999; Laidi et al, 2015; Lee & Kim, 2011; Mantere et al, 2004; Miller et al, 2018; Moon et al, 2012; Nardi et al, 2008; Neves et al, 2009; Newport et al, 2012; Ong et al, 2012; Ortiz et al, 2021; Pacchiarotti et al, 2011; Parker et al, 2013, 2020; Patterson et al, 2009; Prabhavathy et al, 2017; Sanchez-Morla et al, 2019; Sarrazin et al, 2018; Savitz et al, 2015; Simonsen et al, 2011; Talati et al, 2013; Tost et al, 2010; Trotti et al, 2020; Tundo et al, 2015; Van Der Werf-Eldering et al, 2011; Van Rheenen et al, 2017; Yazici et al, 1999; Yilmaz et al, 2015).…”

“…A total of 26 studies ( n = 3316) reported specific proportions for a history of psychosis in BDI patients, with a pooled lifetime prevalence of psychotic symptoms of 67% (95% CI 61–72) (Altindag et al, 2006 ; Cao et al, 2014 ; Davila et al, 2006 ; Dell'Osso et al, 2010 ; Gesi et al, 2016 ; Goldberg et al, 1999 ; Gonzalez-Pinto et al, 2011 ; Grigoroiu-Serbanescu et al, 2010 ; Jamra et al, 2010 ; Javadapour et al, 2010 ; Karakus & Tamam, 2011 ; Kent et al, 2020 ; Kirov & Murray, 1999 ; Laidi et al, 2015 ; Lee & Kim, 2011 ; Mantere et al, 2004 ; Nardi et al, 2008 ; Ong et al, 2012 ; Pacchiarotti et al, 2011 ; Parker et al, 2013 ; Patterson et al, 2009 ; Prabhavathy et al, 2017 ; Sarrazin et al, 2018 ; Tost et al, 2010 ; Trotti et al, 2020 ; Yilmaz et al, 2015 ).…”

Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics

“…According to findings from previous neuroimaging studies, it has been proposed that abnormalities in the sensorimotor domain are related to the dysfunction of the cerebello-thalamo-corticocerebellar network [45]. Additionally, it has been reported that psychomotor slowing is positively related to negative symptoms and mania, regardless of the diagnostic category, among individuals with schizophrenia, schizoaffective disorder, bipolar disorder, and others [46]. Thus, it can be proposed that motor retardation may be the dimensionally defined core constitute of the psychonectome underpinned by the neural network (i.e., the cerebello-thalamo-cortico-cerebellar network) in Asian patients with schizophrenia.…”

What Can Be Learned from Dimensional Perspectives on Psychiatry?

“…Ristanovic et al [8] tested the association between motor abnormalities and cognition in subjects with nonclinical psychosis. Likewise, Kent et al [9] investigated the association of motor behavior with psychopathological dimensions in a sample of 149 subjects including schizophrenia, schizoaffective disorder, bipolar disorder, relatives, and healthy subjects.…”