Exploring the Relationship of Bone Turnover Markers and Bone Mineral Density in Community-Dwelling Postmenopausal Women

Wei, Xu; Zhang, Yili; Xiang, Xinghua; Sun, Mingjie; Sun, Kai; Han, Tao; Qi, Baoyu; Xie, Yan-Ming; Zhang, Ranxing; Zhu, Liguo

doi:10.1155/2021/6690095

Cited by 8 publications

(9 citation statements)

References 42 publications

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“…Bon| turnover markers (BTMs) are a group of metabolites or enzymes which are released by osteoblasts or osteoclasts during the bone remodeling process. BTMs could provide a dynamic picture of changes in bone remodeling, and thus identify changes in the bone remodeling within a relatively short time interval ( 15 ). BTMs are independent predictors of fracture risk and future bone loss ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents

et al. 2022

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ObjectivesTo ascertain the associations of serum bone turnover markers (BTMs) levels with body mass index (BMI) in Chinese children and adolescents, and whether the influence of BMI, age, pubertal stage on BTMs varied by gender.MethodsA total of 500 students (180 controls and 320 children and adolescents with overweight/obesity) aged 9–14 years were randomly selected from the Chinese National Survey on Students Constitution and Health Cohort. Serum levels of BTMs, including bone formation marker bone alkaline phosphatase (BAP), collagen type 1 C-terminal propeptide (CICP), and bone resorption markers C-terminal telopeptide of type-I collagen (CTX) were determined by commercial enzyme-linked immunosorbent assay kits. The associations among BMI, age, gender, pubertal stage, and BTMs were analyzed.ResultsSerum levels of CICP and CTX in overweight/obese children and adolescents were lower than those in controls (p<0.05). Moreover, after subgroup analysis stratified by gender, the decreased serum CICP and CTX levels in overweight/obese children and adolescents were observed only in boys (p<0.05). After adjustment of age and pubertal stage, there was a negative correlation between serum BAP and BMI in both boys and girls (p<0.05). However, the correlations between serum CICP, CTX levels, and BMI were significant in boys but not in girls. Serum BAP and CICP levels were independently correlated with BMI, age, gender, and pubertal stage, while CTX levels were independently correlated with BMI, age, and gender (p<0.05). BAP, CICP, and CTX levels showed a clear age, gender, and pubertal stage dependence with significantly higher values in boys (p<0.05).ConclusionsOur findings support the associations between serum BTMs levels and BMI in Chinese children and adolescents, and suggest age, gender, and pubertal stage differences in this relationship that warrant future studies.

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Section: Introductionmentioning

confidence: 99%

The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents

et al. 2022

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“…Bone resorption and bone formation are collectively known as bone turnover, which allows for the removal and replacement of old and damaged bone, thus maintaining bone strength [51]. Former studies have shown that markers of bone resorption and bone formation may present with high concentrations during puberty [52,53]. In the results of the binary logistic regression analysis in this study, these ve markers did not differ signi cantly between the two groups.…”

Section: P Valuesmentioning

confidence: 39%

The Relationship between Dental Caries, Bone Mineral Density, and Bone Metabolism among Adolescents

et al. 2023

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Background: Bone development, particularly important during adolescence, can be affected by a variety of factors that can lead to the development of bone diseases such as osteoporosis or fractures. Whether dental caries is related to skeletal status, or whether lack of calcium affects the teeth, is always the question that clinical patients want to have answered. The present study was aimed to compare the bone mineral density and bone metabolism of adolescents with and without dental caries. Methods: Adolescents were enrolled in the dental caries and caries-free groups, respectively. A questionnaire and clinical oral examination in terms of DMFT scores were conducted. Bone mineral density (BMD) was tested and peripheral blood was collected for bone metabolism assessment. Results: 119 and 140 adolescents were included in the dental caries and caries-free groups. The mean BMD and Z-score of the two groups showed no statistically significant difference. Serum concentrations of ALP, bone alkaline phosphatase, N-terminal osteocalcin, peptide of type I procollagen, and β-cross-linked C-telopeptide of type 1 collagen levels in the dental caries group were significantly lower than in the caries-free group (p < 0.05). Serum calcium, phosphorus, magnesium, 25-OH-VitD, and parathyroid hormone were not statistically different between two groups. Multiple factor logistic regression showed that serum calcium concentration in males had an OR of 2.55 for dental caries (p< 0.001). Conclusions: BMD and majority of bone metabolism indexes were not related with dental caries among Chinese adolescents. For male adolescents, serum calcium level was associated with higher risk of dental caries.

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“…ALP, N-MID, and β-CTX are markers of bone formation and resorption, which can be easily detected and directly reflect the change in bone metabolism before bone morphological change ( 14 , 21 ). β-CTX is a C-terminal cross-linked peptide of type I collagen, which is produced in the process of collagen decomposition and can be used to indirectly reflect the function and activity of osteoclasts in the skeletal system ( 22 ). β-CTX was stable for 8 h at room temperature and 48 h at 4°C in serum ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…β-CTX was stable for 8 h at room temperature and 48 h at 4°C in serum ( 23 ). It could be considered an ideal and stable marker to reflect bone resorption ( 22 ). N-MID is the hydrolytic fragment of osteocalcin secreted by osteoblasts and can be used to reflect the process of bone formation.…”

Section: Discussionmentioning

confidence: 99%

Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study

et al. 2022

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ObjectivesThis study aims to explore the relationship between bone-turnover biomarkers and the recovery of SSNHL to provide clues for further improvements in etiological research and predictors.MethodsThe medical history, hearing thresholds, biomarkers of bone-turnover, and related hormones of 117 SSNHL patients were collected prospectively between August 2018 and December 2021. Linear correlation and logistic regression models were applied to examine the association between bone-turnover biomarkers and the prognosis of SSNHL.ResultsAge, the incidence of vertigo, pure tone average of the impaired frequencies (PTAimpairedfre), and the levels of bone turnover [including alkaline phosphatase (ALP), β-carboxy terminal crosslinked telopeptide of type 1 collagen (β-CTX), and N-terminal-midfragment of osteocalcin (N-MID)] were higher in the nonresponders than responders (P < 0.05). Logistic regression showed that the age (OR = 1.035, P = 0.027), time to treatment (OR = 1.157, P = 0.038), PTAimpairedfre (OR = 1.031, P = 0.008), and β-CTX (OR = 1.004, P = 0.001) were independent risk factors for the prognosis of SSNHL. In the women SSNHL subgroup, age, postmenopause percentage, PTAimpairedfre, the activity of ALP, levels of β-CTX, and N-MID were significantly higher in the nonresponders than the responders (P < 0.05). Compared to the men SSNHL subgroup, β-CTX has a higher correlation coefficient and predictive efficiency in the women SSNHL subgroup, and logistic regression showed that β-CTX (OR = 1.004, P = 0.004) was an independent risk factor for the women SSNHL.ConclusionsBone-turnover biomarkers are risk factors for poor prognosis in SSNHL, especially β-CTX. The differences were significant in women SSNHL, which may be related to the rapid regression of estrogen after menopause that leads to the occurrence of osteoporosis with a high conversion rate.

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Exploring the Relationship of Bone Turnover Markers and Bone Mineral Density in Community-Dwelling Postmenopausal Women

Cited by 8 publications

References 42 publications

The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents

The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents

The Relationship between Dental Caries, Bone Mineral Density, and Bone Metabolism among Adolescents

Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study

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