Exploring the Relationship Between Movement Disorders and Physical Activity in Patients With Schizophrenia: An Actigraphy Study

Pieters, L; Deenik, Jeroen; Tenback, Diederik E.; Oort, Jasper van; Harten, Peter N. van

doi:10.1093/schbul/sbab028

Cited by 15 publications

(13 citation statements)

References 65 publications

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“…The three clusters are clinically plausible and may help to define subtypes of the heterogenous SSD syndrome, benefitting future diagnostic efforts. In addition, our results support the phenomenon of co-occurrence of sensorimotor abnormalities described by Walther and colleagues [7] and are also in line with a recent actigraphy study by Pieters and colleagues [57] that showed a significant relationship between parkinsonism and low physical activity and between akathisia and higher physical activity.…”

Section: Discussionsupporting

confidence: 93%

Characterizing the sensorimotor domain in schizophrenia spectrum disorders

Fritze

Sambataro

Kubera

et al. 2021

Eur Arch Psychiatry Clin Neurosci

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The rapidly evolving field of sensorimotor neuroscience reflects the scientific and clinical relevance of sensorimotor abnormalities as an intrinsic component of the disease process, e.g., in patients with schizophrenia spectrum disorders (SSD). Despite previous efforts, however, prevalence rates and relationships between different categories of sensorimotor abnormalities in SSD patients are still subject of ongoing debate. In this study, we examined five different categories of the sensorimotor domain (Neurological soft signs (NSS), parkinsonism, catatonia, akathisia, and tardive dyskinesia) according to well-established clinical ratings scales and the respective cut-off criteria in a sample of 131 SSD patients. We used a collection of statistical methods to better understand prevalence, overlap and heterogeneity, as well as psychopathological and cognitive correlates of sensorimotor abnormalities. 97.7% of the SSD patients considered by this study exhibited at least one categorically defined sensorimotor abnormality that tended to co-vary within three different sensorimotor subgroups (moderate, hyperkinetic and hypokinetic). Finally, hyperkinetic and hypokinetic groups differed significantly in their neurocognitive performance compared with the moderate group. The results suggest different patterns of clinical overlap, highlight the relationship between sensorimotor and cognitive domain and provide clues for further neurobiological studies.

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Section: Discussionsupporting

confidence: 93%

Characterizing the sensorimotor domain in schizophrenia spectrum disorders

Fritze

Sambataro

Kubera

et al. 2021

Eur Arch Psychiatry Clin Neurosci

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“…In schizophrenia, associations between physical activity and negative syndrome ( 30 , 31 , 63 ), dosage of antipsychotic medication ( 64 ), and the development of motor activity over the course of schizophrenia ( 65 ) have been investigated. Besides catatonia, actigraphy has been implemented in the investigation of other motor abnormalities such as (antipsychotic-induced) akathisia ( 32 , 66 ), parkinsonism ( 36 , 66 ), dystonia ( 66 ), and restless legs syndrome ( 67 ). Furthermore, psychomotor behaviors in other mental disorders such as major depressive disorder (MDD) have been investigated using actigraphy ( 68 – 70 ).…”

Section: Discussionmentioning

confidence: 99%

Measuring catatonia motor behavior with objective instrumentation

et al. 2022

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ObjectiveCatatonia is a neuropsychiatric syndrome, with important psychomotor features, associated with schizophrenia and other psychiatric disorders. The syndrome comprises multiple symptoms including abnormal motor control, behaviors, volition, and autonomic regulation. Catatonia assessment relies on clinical rating scales and clinicians familiar with the catatonia exam. However, objective instrumentation may aid the detection of catatonia. We aimed to investigate the relationship between movement parameters derived from actigraphy and expert ratings of catatonia symptoms measured by the Bush Francis Catatonia Rating Scale (BFCRS) and the Northoff Catatonia scale (NCS).MethodsEighty-six acutely ill inpatients with schizophrenia spectrum disorders were assessed with the BFCRS, the NCS, and 24 h continuous actigraphy. Non-wear and sleep periods were removed from the actigraphy data prior to analysis. Associations between total catatonia scores, derived from both BFCRS and NCS, and actigraphy parameters as well as between single BFCRS items and actigraphy parameters were calculated using Spearman's rank correlation and non-parametric ANCOVAs (Quade's ANCOVAs), respectively.ResultsBoth higher BFCRS total scores (r = 0.369, p = 0.006) and NCS total scores (r = 0.384, p = 0.004) were associated with lower activity levels (AL). Higher scores on single BFCRS items such as immobility/stupor or staring were linked to lower AL (immobility/stupor: F = 17.388, p < 0.001, η2 = 0.175; staring: F = 7.849, p = 0.001, η2 = 0.162) and lower metabolic equivalents of task (MET).ConclusionSpecific catatonia symptoms such as immobility/stupor and staring can be measured with actigraphy. This may aid the detection, staging, and monitoring of catatonia in clinical settings.

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“…25,27,29,30 Furthermore, actigraphy studies in psychosis linked sedentary behavior to illness chronicity, poor cognition, parkinsonism and catatonia. 23,[31][32][33][34] Gait analysis is another instrumental method to assess gross motor behavior, yet limited to the lab setting. For example, gait velocity is reduced in patients with schizophrenia compared to healthy controls (HC).…”

Section: Introductionmentioning

confidence: 99%

The Behavioral Mapping of Psychomotor Slowing in Psychosis Demonstrates Heterogeneity Among Patients Suggesting Distinct Pathobiology

Nadesalingam

Lefebvre

Alexaki

et al. 2022

Schizophrenia Bulletin

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Objectives Psychomotor slowing (PS) occurs in up to half of schizophrenia patients and is linked to poorer outcomes. As standard treatment fails to improve PS, novel approaches are needed. Here, we applied the RDoC framework using 3 units of analysis, ie, behavior, self-report, and physiology to test, whether patients with PS are different from patients without PS and controls. Methods Motor behavior was compared between 71 schizophrenia patients with PS, 25 without PS, and 42 healthy controls (HC) using 5 different measures: (1) for behavior, an expert rating scale: Motor score of the Salpêtrière Retardation Rating Scale, (2) for self-report, the International Physical Activity Questionnaire; and for physiology, (3) Actigraphy, which accounts for gross motor behavior, (4) Gait velocity, and (5) coin rotation task to assess manual dexterity. Results The ANCOVAs comparing the 3 groups revealed differences between patients with PS and HC in expert ratings, self-report, and instrumental measures (all P ≤ .001). Patients with PS also scored higher in expert ratings and had lower instrumental activity levels compared to patients without PS (all P ≤ .045). Instrumental activity levels correlated with an expert rating of PS (rho = −0.51, P-fdr corrected <.001) and classified similarly at 72% accuracy. Conclusions PS is characterized by slower gait, lower activity levels, and slower finger movements compared to HC. However, only actigraphy and observer ratings enable to clearly disentangle PS from non-PS patients. Actigraphy may become the standard assessment of PS in neuroimaging studies and clinical trials.

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Exploring the Relationship Between Movement Disorders and Physical Activity in Patients With Schizophrenia: An Actigraphy Study

Cited by 15 publications

References 65 publications

Characterizing the sensorimotor domain in schizophrenia spectrum disorders

Characterizing the sensorimotor domain in schizophrenia spectrum disorders

Measuring catatonia motor behavior with objective instrumentation

The Behavioral Mapping of Psychomotor Slowing in Psychosis Demonstrates Heterogeneity Among Patients Suggesting Distinct Pathobiology

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