Exploring the relationship between autophagy and Gefitinib resistance in NSCLC by silencing PDLIM5 using ultrasound-targeted microbubble destruction technology

Zhang, Yao; Lv, Wenhao; Li, Hui; Dong, Ting; Wu, Hao; Su, Chunhong; Shu, Hong; Nie, Fang

doi:10.1186/s12935-022-02718-4

Cited by 2 publications

(2 citation statements)

References 42 publications

(41 reference statements)

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“…In LC, high expression of PDLIM5 accelerates metastasis by competitively binding Smad3 with the E3 ubiquitin ligase STUB1 and promoting TGFβ signaling activation and EMT [68]. Similarly, others have probed and found a trend toward better survival in NSCLC patients with low PDLIM5 expression [136]. High expression of PDLIM5 also promotes gefitinib resistance by inhibiting autophagy in PC9GR cells [137].…”

Section: Pdlim4mentioning

confidence: 97%

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

Jiang,

Xu,

Jiang

et al. 2023

Cancers

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PDZ-LIM family proteins (PDLIMs) are a kind of scaffolding proteins that contain PDZ and LIM interaction domains. As protein–protein interacting molecules, PDZ and LIM domains function as scaffolds to bind to a variety of proteins. The PDLIMs are composed of evolutionarily conserved proteins found throughout different species. They can participate in cell signal transduction by mediating the interaction of signal molecules. They are involved in many important physiological processes, such as cell differentiation, proliferation, migration, and the maintenance of cellular structural integrity. Studies have shown that dysregulation of the PDLIMs leads to tumor formation and development. In this paper, we review and integrate the current knowledge on PDLIMs. The structure and function of the PDZ and LIM structural domains and the role of the PDLIMs in tumor development are described.

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Section: Pdlim4mentioning

confidence: 97%

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

Jiang,

Xu,

Jiang

et al. 2023

Cancers

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“…PDT and siRNA synergistically improve cancer treatment outcomes. Numerous studies have shown that siRNAs are highly effective at improving the responsiveness of cancer cells to PDT by targeting genes associated with autophagy [142]. The collective delivery of siRNA and an NP-based photosensitizer might be a crucial therapy method.…”

Section: Cancer Treatment Using Photodynamic Therapy-based Nanotechno...mentioning

confidence: 99%

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

et al. 2023

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Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis and treatment. Nanomaterials are extensively employed in the field of oncology because of their minute size and ultra-specificity. A wide range of nanocarriers, such as dendrimers, micelles, PEGylated liposomes, and polymeric nanoparticles are used to facilitate the efficient transport of anti-cancer drugs at the target tumor site. Real-time labeling and monitoring of cancer cells using quantum dots is essential for determining the level of therapy needed for treatment. The drug is targeted to the tumor site either by passive or active means. Passive targeting makes use of the tumor microenvironment and enhanced permeability and retention effect, while active targeting involves the use of ligand-coated nanoparticles. Nanotechnology is being used to diagnose the early stage of cancer by detecting cancer-specific biomarkers using tumor imaging. The implication of nanotechnology in cancer therapy employs photoinduced nanosensitizers, reverse multidrug resistance, and enabling efficient delivery of CRISPR/Cas9 and RNA molecules for therapeutic applications. However, despite recent advancements in nano-oncology, there is a need to delve deeper into the domain of designing and applying nanoparticles for improved cancer diagnostics.

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Exploring the relationship between autophagy and Gefitinib resistance in NSCLC by silencing PDLIM5 using ultrasound-targeted microbubble destruction technology

Cited by 2 publications

References 42 publications

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

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