Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents

A DABCO Derived Ionic Liquid Based on Tetrafluoroborate Anion: Preparation, Characterization and Evaluation of its Catalytic Activity in the Synthesis of 14-Aryl-14H-dibenzo[a, j]xanthenes

“…4 ] in the synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes, at first, the synthesis of compound 3e was selected as a model reaction to determine suitable reaction conditions. The reaction was carried out by heating a mixture of β-naphthol (1) (4 mmol) and 4-chlorobenzaldehyde (2e) ( (Table 1).…”

“…The catalyst 4 ] is soluble in water and could therefore be recycled as the filtrate. The catalyst was recovered by evaporation of the water, washed with diethyl ether, dried at 50 °C under vacuum for 1 h, and reused in another reaction with only slight reduction in the catalytic activity.…”

“…The synthesis of xanthenes and dibenzoxanthenes' derivatives have received significant attention in recent years because of their wide range of biological and pharmaceutical properties such as agricultural bactericide, 1 anti-viral, 2 antibacterial, 3 and anti-inflammatory 4 activities. Also, a number of these compounds have been considered as dyes and fluorescent visualization materials for biomolecules and laser technologies.…”

One-Pot Synthesis of 1,8-Dioxo-octahydroxanthene Derivatives Using Zn(NO3)2 under Solvent-free Conditions

“…Xanthene derivatives are one of the important classes of organic compounds which are biologically important drug intermediates in the field of medicinal chemistry for their biologically active properties, such as antimalarial, antibacterial, antiinflammatory, and antiviral properties and have been used as dyes, fluorescent material and in laser technologies [6][7][8][9] . Recently, several improved methodologies have been developed that use triethylbenzyl ammonium chloride 10 , p-dodecyl benzenesulfonic acid 11 , phosphomolybdic acid supported on silica gel 12 , sulfonic acid on silica gel 13 , HClO 4 -SiO 2 14 and ZnO 15 among others.…”

Green catalytic synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes using recyclable mesoporous zirconia modified with tungstophosphoric acid

“…On the other hand, xanthenes and benzoxanthene derivatives have received considerable interest from the pharmaceutical industry due to their wide range of interesting biological and therapeutic properties (19) such as anti-inflammatory (20), antibacterial (21), antiviral (22), CNS stimulating (23) activity as well as their use in photodynamic therapy (PDT: a method of treating tumors by the combined use of photosensitizer and light) (24) and for antagonism of the paralyzing action of zoxazolamine (25). The other useful applications of these heterocycles are as dyes (26), fluorescent materials for visualization of biomolecules (27), luminescent sensors (28), and in laser technologies (29).…”