Exploring the potential of treating chronic liver disease targeting the PI3K/Akt pathway and polarization mechanism of macrophages

Yang, Yugui; Jia, Xiao-Tao; qu, mengyang; Yang, Xinggang; Fang, Yan; Ying, Xiaoping; Zhang, Meiqian; Wei, Jing; Pan, Yanfang

doi:10.1016/j.heliyon.2023.e17116

Cited by 7 publications

(4 citation statements)

References 102 publications

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“…The gut microbiota has recently become a focal point of research. Bile acids play a role in the progression of liver diseases by influencing the function of gut microbiota and immune cells (34). Yang Ming and their team created a clinically relevant murine model of Hepat Mon.…”

Section: Discussionmentioning

confidence: 99%

Macrophages-Mediated Liver Fibrosis: A Bibliometric Analysis

Yao,

Wang,

Liu

et al. 2024

Hepat Mon

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Background: Macrophages play a significant role in both the development and regression of liver fibrosis, engaging in related pro-inflammatory and anti-inflammatory processes. In recent years, an increasing number of studies have elucidated the mechanisms by which macrophages influence liver fibrosis. Objectives: This bibliometric analysis aims to investigate the research trends in liver fibrosis regulation by macrophages through a systematic literature review. Methods: We conducted a search for literature, including research articles and reviews, using the keywords 'liver fibrosis and macrophages' and 'liver cirrhosis and macrophages' in the Web of Science database, covering the period from 2007 to 2023. We retrieved and analyzed publications on liver fibrosis mediated by macrophages from the Web of Science Core Collection database on October 8, 2023. Visualization analysis was performed using CreateSpace (version 6.1.R6), VOSviewer (version 1.6.19), and Scimago Graphica (version 1.0.34.0). Results: We identified a total of 1732 records in the WoSCC, of which 1664 papers were ultimately included in our analysis. China emerged as the country with the most significant number of publications, while Germany and the University of California San Diego stood out for their influence, with centralities of 0.41 and 0.14, respectively. Frank Tacke was identified as the most prolific author, contributing 49 papers. Hepatology was the journal with the highest number of publications and citations. The most frequently mentioned keywords in this field were liver fibrosis, expression, hepatic stellate cells, activation, inflammation, and macrophages. Conclusions: The study of macrophage-mediated liver fibrosis, particularly the mechanisms regulating the heterogeneity of hepatic macrophages, is a mature and promising research area. Macrophage-based therapies for liver fibrosis are anticipated to be crucial topics in the future. Bibliometric analysis offers valuable insights for future basic research directions and clinical practice.

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Section: Discussionmentioning

confidence: 99%

Macrophages-Mediated Liver Fibrosis: A Bibliometric Analysis

Yao,

Wang,

Liu

et al. 2024

Hepat Mon

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“…Hepatic inflammation and fibrosis are triggered by the activation of liver-resident macrophages (or Kupffer cells). Because of macrophage plasticity, these cells may be polarized into various phenotypes by different microenvironmental stimuli[ 35 ]. The polarization of macrophages into phenotypes such as M1 (with proinflammatory properties) or M2 (with anti-inflammatory effects) is regulated by complex cell-signaling pathways such us the phosphoinositide 3-kinase (PI3K)/Akt pathway.…”

Section: Comorbidity Impact On Il-mediated Therapy In Liver Diseasesmentioning

confidence: 99%

“…Conversely, the inhibition of PI3K/Akt signaling can increase the M1-like phenotype, which increases liver impairment. Plant chemicals may be used to effectively treat CLD in future liver disease therapies by targeting the PI3K/Akt pathway to regulate the polarization of macrophages and their activity[ 35 ].…”

Section: Comorbidity Impact On Il-mediated Therapy In Liver Diseasesmentioning

confidence: 99%

Interleukin-mediated therapies in liver diseases and comorbidity effects

Bouare,

Delwaide

2024

World J Hepatol

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Cytokines like interleukins (ILs) play important roles in inflammation and innate immune. Yang and Zhang carried out an interesting study related to ILs and hepatic diseases. They described the role of ILs in the pathogenesis and resolution of hepatic disorders. The authors summarized alcohol-related liver disease and virus-induced hepatitis, as far as clinical studies a fortiori carried out on IL-mediated treatments pertaining to these dysfunctions. This editorial contributes to the review by Yang and Zhang titled, "Interleukins in liver disease treatment", and focuses on therapies mediated by ILs in comorbid liver diseases. The documentary search was conducted on recent pertinent literature, primarily using the Google Scholar and PubMed databases.

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“…Role in promoting M2 polarization. The phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, which plays a crucial role in regulating macrophage polarization and the balance between pro-inflammatory M1 and anti-inflammatory M2 states, has recently become a research focus in chronic liver diseases due to its role in promoting M2 polarization ( Yang et al, 2023 ). Chronic exposure to alcohol leads to increased activation of the PI3K/Akt signaling pathway in macrophages ( Cheng et al, 2022 ; Mehra et al, 2022 ).…”

Section: The Mechanism Of Macrophage Polarization In Alcohol-associat...mentioning

confidence: 99%

Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

Sun,

Zhao,

Shi

et al. 2023

Front. Cell Dev. Biol.

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Alcohol-associated liver disease (ALD) is a condition that develops due to prolonged and excessive alcohol consumption. It encompasses various stages of liver damage, including fatty liver, alcoholic hepatitis, and cirrhosis. Immune cells, particularly macrophages, of various types play a significant role in the onset and progression of the disease. Macrophages observed in the liver exhibit diverse differentiation forms, and perform a range of functions. Beyond M1 and M2 macrophages, human macrophages can polarize into distinct phenotypes in response to various stimuli. Recent advancements have improved our understanding of macrophage diversity and their role in the progression of ALD. This mini-review provides a concise overview of the latest findings on the role and differentiation of macrophages in ALD. Additionally, it discusses potential therapeutic targets associated with macrophages and explores potential therapeutic strategies.

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Exploring the potential of treating chronic liver disease targeting the PI3K/Akt pathway and polarization mechanism of macrophages

Cited by 7 publications

References 102 publications

Macrophages-Mediated Liver Fibrosis: A Bibliometric Analysis

Macrophages-Mediated Liver Fibrosis: A Bibliometric Analysis

Interleukin-mediated therapies in liver diseases and comorbidity effects

Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

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